Oncorhynchus keta (chum salmon): 118387158 Help Entry 118387158         CDS       T09424                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism oke  Oncorhynchus keta (chum salmon) Pathway oke04020   Calcium signaling pathway oke04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oke00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118387158    04020 Calcium signaling pathway     118387158  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oke04040]     118387158 Ion channels [BR:oke04040]  Voltage-gated cation channels   Ryanodine receptor    118387158 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  118387158 NCBI-ProteinID:  XP_052379296 LinkDB All DBs Position 8:39979966..40288361 Genome browser AA seq 4932 aa AA seqDB search MAEGGEGEDDIQFLRTDDEVVLQSVATIQKENRKFCLSVEGLGNRLCFLEPTSEAKYVPP DLCICCFILEQSLSVRALQEMLAHTVPNNEGAAQGGGHRTLLYGHAILLRHSFSGMYLTC LKTSRSLTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSTERYL HLSISSGSFQVDASFMQTLWNVQPTCSGSNVAVGFLCGGHVMHLCHGHDESLTIPGSEAS EMEQRIVNYEMGKGASRARSLWRLEPLRIGWSGSHIRYGQAFRLRHLSTGHYLALTEEHG LVLQEREKSDIKSTSFCFRATKEKIESGTKNRDIEGMGVAEIKYGDSACFVMHVATGLWL SYQAPDAKASRIGPLKRRACLHAEGHMDDGLTLQRCQHEEARAVRIIRNTTVLFSHFIKG LDSIGRDKNVEVSLPNFDEVLQTLDDLIEYFKQPDSELEHEEKQTLLRSLIKRQDLFKEE GMLALLVMCIDRLNLYNSAAHFGEHAGEEAGAAWKSILNLLYQLLASLIKGNRNNCTQFS RNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLYKHGRNHKILD VLCSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVAEGSAQYKK WYFELMIDQVDHYVTSEPSHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLHL WSGRISRAVASINQHLLSSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGFFFPVV SFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMRVEAVKEYKRDHGGVRDLLG TTQFLSQASFIPTPVDTSQIVQPPHLTTCVTDFENIHELWGMNKIELGWSYGKVRDDNKR QHPCLVDFTKLPETERNYNLQMSSETLKTLLALGCHVTQTNVNAEDDLKKVKLPKDYVMS NGYKPTPLDLSEEKLTAGHEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKSRRNPRLV PYALLDERTKKSNRDSLREAIRTLVGYGYNIDPPDQESCHIVERQSIETVRFFRVEQTYA VKTGKWYFEFEALTGGDMRVGWARPGCRSDFDLGMDDQAYIFDGYKGRRMHMGARFFGQS WNKGDVVGCMINMEDKSMVFTLNGELLITNKGSELCFVDFETDDGFIPVCCLAQSEIGRM NLGKDASSFKYYTTCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNIPKDHNHIEVTRIDG TVDNPPCLKVTHKTFGTQQSNSDMLYCRLSMPVELHAPHVNPAESQKLSQPPKEDDYGSI TTYYHSVRVFAGQDPASVWVGWVTPDYHYHSKQFSLNKTRTVTVTLGDERGRVHESVRRS NCYMVCAGDVVGSSHSSSRSNIDLEIGCLVDLATGFLSFTANGKELATTYEVESNTKLFP AVFVRPTSKNLFQFEFVKIKDAMPLSSAIFKSEQRNPVPQCPPRLDVQTIVAVLWSRMPN TFLTVETARVSERHGWVVQCLEPLQMMAVHIPEENRCLDILELSENEGLRKFHYHTLMLY CALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLMSIHLETAKEARLMM NNEFIIPVTDETRSIKLFPDESKRHSLPGVGLSTSLKPRLNFSPLSFITTKKQQHLHSPQ IPLGILKEKAISMLTEAVQGGGSHIRDPVGGSVEYQFVPILKLIGTLLIMGVLSSEEVRL ILLLIDPNVFGEPDEEEVAASAGGGEKEEVSSNEEKAVEAGEEETKEVKPTVKGLLEKTL PESVKRQMCELLHYFCDCELKQRIEAIVSFSDRFVSKLQYNQKFRYNELMLALNMSAAVT AKKTKEFRSPPQEQINILLNFAAGEDCPCPEEIQEDLYSFHDELRLHCGIPVEEEEEEED TSIKGRLLAMLYKIKGPPKKLEEEPTEEEQAAPTNLKELISQTMASWAQECSIQDPELVR VMFSLLRRQYDGIGALLRAMKKSYTISAVSVELSSLILLLVIQLISLRGDKSQEIAFPKM VASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAASSVMDNNS LALALEEPDLEKVVTYLAGCGLQSCVMLLAKGYPDIGWNPIEGERYLSFLRFAVFSNGES VEENSNTVVKLLIRRPECFGPALRGEGGNGLLAAMLEAIKISEDPALDLPCTANGEPSGS GEDEEEEVAHTGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTTDLV GIISIPLKMPIVNKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGVEDQSFLLHLLEVGFL PDLRASASLDTDVLSTTETALAMNRYIGSALLPLLTRCADQFSGTEHYAALIDSTLHTIY RLSKGRSLTKAQRDSIEECLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCKMPLRLLTEH YEQSWKYYCLPSGLGSSGMASEEELLLTKKLFWGIFDSLSTKRFDSDLFKTAMACLSAIS GALPPDYVDAGPGIILEKQASVDAHGNFDPKPINTANMSLPEKLDYIANKFAEHSHVKWS SEKVTAGWKMGDCVDDDAKTHPLLKPYKSLSEKERETYRWPVKESLRSMLALGWNMERTK EGEAMLIRKQSKISESTQDNDNEFIPEPPLDLNNITLSRELQGMVEVVAENYHNIWAKKK KAELSSKGGGSHPLLVPYDTLTAREKYRDREKVQDLFKFLQINGYTITRGLKDVEQDSSS MEKRFAYTFLKRLLKNVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLIDMYF KNHSLYFLSSPSKNLSSSGYASNKEKEMITSLFCKMAALVRHRISLFGSDSAIMVSCLHI LAHSLDTRTVMKSGSEMVKAGVRTLFENAAEDLEKTLEMLKLGKFSQSRSQMKGLSQNIT YATTALLPILTALFEHVTMHNFGVGLLVDDVQLSCYRIVTCLYSLGTGKHIFMERHLPAL GECLATLVGAMPVAFLEPDLNAHNPLSVFNTKTPRERAILSMPDSVEEMCSEVPRLDRLL KDINDISESGARYTEMPQVIEVILPMLCNYLSYWWERGTENSAPHTACCTTVCSNHLSII LGNILKILNNNLGIDDAPWMKRIAVYSQPIICKAAADLLKSHFLPTLEKLRKKTVKVVAE EELLKADIKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYMDNNRSRWLKRPDAQSNELF TMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGERKTKMSKSGGDQDRKHSLSALD LLSLSRPLCVSLSLSLKKISLPDSTSLSQESELHSQVVTRIGSTVWRVILIIQTLETDHL IEEDTAAHRSSTCANPGDQELISLAKIRYSLKDTDDEVKDHLRENLHLQDKSDDLAVQWQ MNLYKDVVVGSEEHADPEQTVDRIQSISAAVFHLEQVEQPLRMKKCVFQKLLSKQRKRAV VACFRMAPLYNLPRHRSINLFVLGYVRLWIETEEYSFEEKLVQDLAVSTGHVAMVSATTS ALASALPPVPCVGTAPLPALFADSLLSTMPAVQLRDRDRFPVRLGPGTSTWAPRGSRGPR ALSSFVARYRQSLDRHDRLNLRRLSGSNGSVSAAKHVARKTGYGMGYLTTTTTTTVLTER SFLEEDPLYIAYADMMAKSCAEDEEEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAA EMVLQMISASKGRLGPMVTCTLKLGISILNGGNVLVQQKMLDYLKEKRDAGFFKSLSGLM QSCSVLDLNAFERQNKAEGLGMVTDEGSCSKVLTNDDFTKDLFRFLQLLCEGHNGDFQNF LRTQTGNTLTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDEAGQVNFSKALAVAKQIF NSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSCQIELLKELMDLQQD MVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKIKDLTTSDNFREYDP DNKGVISKKDFQKSMENQKQYTQSEIEFLLSCAEADENDMFNYEEFVERFHEPAKDIGFN IAVLLTNLSEHMPHDPRLATFLEPAESVLNYFEPYLGRIEIMGGGKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQLASQISEPEVAERPEE EEEEVHNLLEELAEQEEERELEASSAFTMVCVAAKKKISNFRQMLTFKTLKKQYKKTKKL SMKEVIIGFFSFFWTLFAGFFKGIYSLIFGFFHLIWSSMFGGGLVEGAKNMKVTDILGNM PDPTQFGIHGDVLETEKVEVGDSVSGGTDQAIKPSDKAEQDILMEMINPTPKKGEGLKHV DPGLGDVSETPETSTAVEKKKAASEPMELEPEKADTEKKEKEDKVKAEQPKEEVAQDKPV PKSRNSQSKEAPTSFFASFLSGLEVYQAKMLNTLARNFYNMRFLALFVAFAINFILLFYK VTAAEDDEDDSWTSSDDDDEGGEEYFVLEESTGYMAPILCFLAVFHTALSILCLVGYYFL KVPLVVFKREKGIARLLEFEGLYITEQPADDDITGQWDRLVINTPSFPNNYWDKFIKRKV INKYGDLYGAERIAELLGLDKSALDFDPTQETVVEEASLVSWLSSIDTKYHIWKMGVVLT DNSFLYLIWYATMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDEDAPDMKCDDMMTCYLFHLYAGVRAGGGIGDELEDPA GDPYELWRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGN DYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG DCFRKQYEDLLG NT seq 14799 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgatatacagttcttgcgaactgatgacgaggtg gtgctgcagagtgtcgccaccatccagaaggagaatcgcaagttttgtctgtccgtggag ggactcggaaatcgactatgcttcctagaacctacatctgaagctaagtatgttcctcct gacctgtgtatctgctgtttcatcctggagcagtccctgtctgtccgagccctgcaggag atgttggctcatacagtgcctaacaatgagggggcggcccaggggggtggacaccggacc ctgctctatggtcacgccatcctcctacgccactccttcagcggaatgtacctgacctgc ttgaagacatcgaggtcattgacagacaaactgtcatttgacgtgggattacaagaagat tcaataggagaggcgtgttggtggaccatccaccctgcgtccaagcagaggtcagaggga gagaaggtccgtatcggagacgacctcatcctggtcagcgtgtccacagagaggtacctg cacctgtccatctccagcggtagtttccaggtggatgcctcctttatgcagactctgtgg aacgtccagcctacctgctcaggaagcaacgtggctgtaggattcctgtgtggtggtcac gtgatgcatctttgtcacgggcatgatgagagtctgaccatacctgggtcagaggctagc gagatggagcagaggatagtgaactatgagatgggtaaaggagcatccagggcccgctct ctctggaggctggagcccctcaggatcggttggagcggtagccacattcgctatgggcag gcgttccgtctgcgtcacctgtcaaccggtcactacctggcgctgaccgaagaacatggt ctggtcttacaggagagagagaagtctgatatcaagtccacctctttctgcttcagggct accaaggaaaagatagagtcgggtacaaagaatcgagacatagaaggtatgggagtcgca gagatcaagtatggggactcagcctgcttcgtgatgcacgtggctacaggtctgtggctg tcctatcaggcgcctgacgctaaagcctcccgcataggacccctgaagagaagggcctgt ctgcatgctgagggtcacatggacgacggtctgacccttcagcgttgtcaacacgaggag gcacgggctgtacgcatcatcaggaacaccactgtcctcttcagccacttcatcaagggt cttgacagtataggaagggataagaacgtggaggtctctctgcctaactttgacgaggtg ttgcagacgctggatgatctcattgagtatttcaaacagcccgactcagaactggaacat gaggagaaacagactctgctgagatctctaatcaaacgacaggaccttttcaaagaggag ggcatgctggccctactggtgatgtgcatcgaccgtctcaacctgtacaacagcgctgct cactttggagagcatgctggggaagaggctggggcggcatggaagagcatcctcaaccta ctctaccaactactggcctctctgatcaaagggaaccggaacaactgtactcagttctcc aggaacctggactggctggtcagcaagctggagagactggagtcctcatcaggtatcctg gaggtgctccattgtatcctgatagagtctccggaggctctgaacatcatccagaaagga cacatcaagtccatcatctccctgctctacaaacacggacgcaaccacaagatcctggac gtcctgtgctctctgtgtgtgtgtaacggggtggcagtgagagccaatcagaacctcatc tgtgatcacctgcttccgaagagagacctgctcctccagacacgattggtcaatgacgtt cagagtatgaggcctaacatcttcctaggagtggcagagggttcagcccagtataagaag tggtactttgagttgatgatcgaccaggtggaccactatgtgaccagtgagccatcccac ctgcgtgtgggctgggcctccactaagggttatgccccctacccggggggtggagaggga tgggggggcaacggagtgggtgacgacctttactcatacagctttgacggactccacctg tggtcaggccgtatctcccgggcggtagcctcgatcaaccagcacttgttgagcagtgat gacgtggtgagctgttgtctggacctgggcgctccttccatgtccttcaggatcaacggc cagccagtacagggcatgtttgaagacttcaacaccgacggattcttcttccccgtagtc agcttctctgcaggggtcaaggtgcgtttcctgctgggtggacgtcatggagactttaag ttcctgcccccggcgggttactccccgtgttacgaggccctgctccccaaggagaagatg agggtggaggctgtgaaggagtacaagagagaccatggaggggtcagggacctactgggg acaacacagttcctctcccaggcctcattcatccccacacctgtagacaccagccagatt gttcaacctcctcacctgacaacgtgcgtgacagactttgagaacatccatgaactttgg ggcatgaacaagattgaactgggctggtcctatggcaaggttcgagatgacaacaagagg cagcacccctgcctggtggatttcaccaagctgcctgaaactgagaggaactataacttg cagatgtctagcgaaacactaaagaccctgttggcattgggatgtcatgtgacacagacc aacgttaacgccgaggacgatctgaagaaagtcaaactgcccaaagactatgtgatgtct aacgggtacaagccaactccgctggatctttctgaggagaaactgacggctggtcatgag gttctggtagataaactggcggagaacgctcacaacgtttgggccaaggacaggatcaaa caaggatggacctacggcattcagcaggatgtgaagagcaggcgaaaccctcgtctggtg ccgtacgctttactcgacgagagaaccaagaagtctaacagagacagtctgagagaggcc atcaggaccctggtgggatatggctacaacatcgaccccccagaccaggaatcctgtcat attgtggagaggcagagcattgagacggtccggttcttccgcgtagagcagacgtatgca gtgaagacagggaagtggtactttgagtttgaggccctgaccggaggggacatgagggtt ggttgggcgagaccaggctgtagatcagactttgacctgggcatggacgaccaggcctac atctttgatggatacaagggccgtcgaatgcacatgggtgcgcgtttcttcggccagtca tggaacaagggagacgtggtgggctgcatgatcaacatggaggacaagtctatggtcttc accctcaatggagagctactcatcactaacaagggatctgagctctgcttcgttgacttc gagacagatgatggcttcatcccagtgtgttgtctggcccagtctgagattggccgtatg aacctggggaaggacgccagcagctttaagtattacaccacgtgtggcctgcaggagggc ttcgaacccttcgctgtcaacatgaacagagaagtcaccatgtggttcagcaaacgcctg cctaccttcgtcaacatccccaaggaccacaaccacatcgaggtgacgaggatagatggg acagtggacaaccctccgtgcctgaaggtgacccacaagacgtttgggacccagcagagc aacagtgacatgctgtactgcagactgagcatgcctgtagagctccacgctcctcatgtc aatcctgccgagtctcagaaactcagtcagcctccaaaggaagatgattatggcagcatt acaacgtattatcactcagtgagggtgtttgctggccaggacccagcatcggtgtgggtt ggctgggtaacccccgactaccattatcatagcaaacaattcagccttaacaagacacgc acggttaccgtaaccctgggagacgagagaggacgcgtccacgagagtgttcgaaggagt aactgctacatggtgtgtgctggagatgttgtcggctcctcccactcctcatcccggtct aacatcgacctggagattggctgtctcgttgacctggcaacaggctttctctccttcaca gccaatggcaaggagctggcgaccacctatgaggtggagtccaacaccaagctgtttcct gctgtgtttgtgcgtcccaccagcaaaaacctcttccagtttgagtttgtcaagatcaag gacgccatgcccctgtcgtcagccatctttaagagtgaacagcgtaaccctgtgccccag tgtcctccacgtctggacgttcagaccatcgtagcggtgctgtggagccgtatgccaaac accttcctcaccgtggagaccgccagggtctcagagagacacggctgggtggtgcagtgt ctggagccactgcagatgatggctgttcatatacctgaggaaaacaggtgtctggacatc ctggagctatcggagaatgagggtctgaggaagttccactaccacaccctgatgctctac tgtgccctctgcgcattgggcaacacccgtgtggcacacgccctctgctcccacctcgac caatcacagctgctctacaccatcgacaaccaatacctgtccggcatgctgagagaggga ttctataatgttcttatgagcatccacctggagacagcgaaagaggctcgtctgatgatg aacaacgagtttattatccctgtgactgatgagacgcgctccatcaagctgttccctgac gagtccaagagacactctctacccggtgtaggcctcagcacctcgctgaaaccacgcctc aacttctcccctctctccttcatcaccaccaagaaacagcagcacctccacagtccccag atccccctgggcatcctgaaggagaaggccatcagtatgctgactgaggcggtgcaggga ggaggcagtcacatcagagacccagtagggggcagtgtggagtaccagtttgtccccatc ctcaagctgatcggaaccttgctgatcatgggggtactctccagcgaggaggtgaggctg atcctgctcctcattgaccctaatgtgttcggggagccggatgaggaggaggtggcagca tcagcaggaggaggagagaaggaggaggtgagcagcaacgaggagaaggctgtggaggct ggtgaggaggagaccaaggaggtcaaaccgaccgtgaagggactgctggagaagacactg cctgagtctgtcaaacgacagatgtgtgagctgctgcactacttctgtgactgtgaattg aagcagcgtatcgaggccatcgtgtccttctcggaccgcttcgtgtccaagctgcagtac aaccagaagttcaggtacaacgagttgatgttggccctcaacatgtctgctgccgtcacc gccaagaagaccaaggagttcagatcccctcctcaggaacagatcaacattctgttaaac tttgctgctggggaggactgtccctgtcctgaagagattcaggaggacctctacagcttc catgatgagctgagactgcactgcggcatcccagtggaggaggaggaggaggaggaagac acgtctataaagggtcgtctgctggccatgctctataagatcaagggaccgcccaagaaa ctagaggaggaacctacggaggaggaacaggccgctcccaccaacctgaaggagttgatc agccagaccatggctagctgggctcaggagtgcagcatccaggacccagagctggttcgt gtgatgttcagcctgctgagacgtcagtacgacggcatcggagcgctgctcagggccatg aagaagagttacaccatctctgctgtgtcagtagaactgtccagtttaatattactctta gtgatccagctcattagtctaagaggagacaagtcacaggagatagccttccccaagatg gttgccagctgctgtcggttcctgtgttacttttgtcgtatcagccgacagaaccagaag gccatgtttgaccatctcagctacttactggagaacagctctgtcggactggcctcccca gcaatgaggggttctactcccctggacgtagcagcgtcttcagtgatggacaacaacagc ctggccctcgctctggaggagcctgaccttgagaaggtggtaacctacctggcaggctgt gggctgcagagctgtgtcatgctcctggctaaaggatatcctgacattggctggaacccc atagagggagagagatatctgtctttcctccgcttcgctgtcttcagcaacggtgagagt gtagaggagaactctaacacggtggtgaagctgctgatcagacgtcccgagtgttttggt cccgctctgagaggagagggaggcaacggtctgctggcggccatgctggaagccattaag atatctgaggaccctgctctggacctgccctgtacagccaatggagaaccttctgggtct ggtgaggatgaggaggaagaggttgcccacacaggaaacgccatcatgtccttttactct gcccttattgacctgctgggacgctgcgcccctgagatgcacttgatcaacaagggtaaa ggtgaggcattgcgtatccgggccatcctgcgctccctggttcctaccacagacctggtg ggcatcatcagtataccactcaagatgcccattgtcaataaagacggtagtgtgacagag ccagacatgtcggctagtttctgtccggaccacaaggcccccatggtgttgtttctggac cgtgtgtacggcgtggaggaccagagctttctgctacacctgttggaggtgggcttcctg cctgacctccgcgcctccgcctccctggacacggatgtgttaagcaccacagagaccgct ctggccatgaacaggtacatcggttcggccctgcttcccctgctgaccaggtgtgctgac cagttctcgggcacggagcactacgcagcgctcattgactctaccctccacactatctat cggctgtccaagggacgctccctcaccaaggcccagagagactctatcgaggagtgtttg cttgccatctgcaaacatctgcgcccttccatgatgcaacagctgctgagacgtctggtg ttcgatgttcccatgctcacagagtactgcaagatgccactcaggctgctgactgaacac tatgagcagagctggaagtactactgtcttccctcggggctggggagctccggcatggcc tcagaggaagaactgctgctcaccaagaaactcttctggggaatattcgactcgctctca acaaagaggtttgactctgaccttttcaagactgccatggcctgtctgagtgccatttct ggggcgttaccgcctgactatgtggatgccggccccggtatcatcctggagaagcaggcg tctgtggacgcacacggcaacttcgaccccaaacccatcaacactgccaatatgtccctt ccagagaaactggactacatcgccaacaagtttgcagagcattcccacgtcaaatggtcc tcagagaaggtgacagcgggatggaaaatgggagactgcgtagatgatgatgccaaaact caccctctgctgaagccttacaagtcactgagtgagaaggagagggagacgtaccgctgg ccagtgaaggagtctctaaggagtatgttagctttgggctggaacatggagaggaccaag gagggagaggccatgttaatcaggaaacaaagcaagatctcagagtccactcaggacaac gataacgaattcatccctgaaccaccactggatctgaacaatattactctatccagagag ttgcaggggatggtggaggtagtagcagagaactaccacaacatctgggccaagaagaag aaggctgagctgagtagtaaaggaggagggagccacccattgctggtgccctatgacact ctgacagccagggagaaatacagagacagagagaaggtccaagatctctttaaatttctt cagatcaatggatacactatcaccagaggcctgaaggacgtggagcaagactcatcgtcc atggagaagaggtttgcttacacgttcctcaagaggttgctgaagaatgtggactcggct caggagttcatcgcccacctagaggccatggccaccagcggaaagacagacaaatcgcct cacgatcaggaaatcaagttcttcgccaaggtgctgctacctctcatagacatgtacttt aagaaccacagcctgtacttcctgtcctcgcccagtaagaacctgagcagcagtggctac gcctcaaacaaggagaaggagatgatcaccagcctgttctgtaagatggcagctcttgtc agacacaggatttccctctttgggagcgactcggctattatggtgagctgtctacacatc ctggctcattccctcgacacaaggacggtgatgaagtcaggctcagagatggtgaaggct ggggtcaggacattatttgagaatgcagcggaggacctagagaagaccctggagatgctg aagctggggaagttcagccagtcccggagccagatgaagggcttgtcccagaacatcacc tacgccaccaccgctctgctgcccatcctcacagccctgttcgaacatgtcaccatgcac aactttggagtcggcctgctggtggatgatgtccagctgtcgtgctatcgcattgtgacg tgtctctactcactgggcacggggaaacacatcttcatggagaggcacctaccagcccta ggggagtgtctggccaccctggtaggagccatgcctgtagctttcctggagcctgatctc aatgctcacaaccccctgtctgtcttcaacaccaagacaccgcgagagagggccatcttg agtatgcctgactctgtggaggagatgtgttcagaggtgcctcgtctggatcgcctgctg aaggacatcaacgacatctcagagtctggagcacgatacacagagatgccacaggtgatt gaggtgatcctgcccatgttgtgtaactacctgtcctactggtgggagagaggaacagag aactctgctccacacaccgcctgctgcactaccgtgtgctccaaccacctcagcatcatc ctggggaacatcctgaagatcctcaacaacaacctgggcattgacgacgctccctggatg aagaggatcgcagtctactctcagccaatcatctgtaaggctgcagcagacctcctgaag agtcacttcctgcccactctagagaaactcaggaagaagacagtcaaggtggtggcagag gaggagctgctgaaggctgacattaaaggagacactcaggaagctgagcttctcattctg gatgagtttgctgtcctctgtagagacctgtatgccttctacccaatgctcatccgctac atggacaacaacaggtccagatggttgaagaggcctgatgctcagtccaacgagctcttc accatggtggctgagatcttcattctctggtgcaaatcacacaacttcaaaagggaagag cagaactttgtggttcagaatgaaatcaacaacctgtctttcttgactggggaacgtaag accaagatgtccaagtcaggtggtgaccaggataggaagcactctctctcggctctggat ctcttatctctgtccagacctctctgtgtatctctttctctctccctgaagaagatctcc ctcccggactcaacatctctctcccaggagtcggagctccacagtcaggtggtgaccagg ataggaagcacagtctggagagttatactcattatccagaccctggagactgatcatctc attgaagaagatacagctgcccatcggagttcaacatgtgctaacccaggagaccaggag ctcatctcattggccaagataagatacagtctgaaagacacagacgatgaggtgaaggat cacttgcgtgagaacctacatcttcaggacaagtccgatgacctggcagtgcagtggcag atgaacctgtataaggatgtggtggtggggagtgaggaacatgcagacccagaacagact gtggacagaatacaaagcatctccgctgcagtcttccacctggagcaggtggagcagcct ctgaggatgaagaagtgtgtgtttcagaagctgctgtccaaacaacgtaagcgtgccgtg gtggcctgcttccgtatggctcctctctacaacctccccaggcatcgttctattaacctc ttcgtgttgggctatgtgagactatggatagagacagaggagtactcctttgaggagaag ctagtgcaggacctggcagtaagtactgggcatgttgcgatggtgtctgccaccacctca gccctagcctcagccttgccccctgtgccctgtgttggcaccgcacccctacccgccctc ttcgccgacagcctcttgagcacgatgcccgccgtccaacttcgggatcgggatcgcttc ccggtccgcctgggtccggggacctcgacttgggcccccagaggttcccgaggcccccgc gctctctctagctttgtggctcgctaccggcagagccttgacagacatgacaggctcaac ctcaggagactcagtggcagcaatggctctgtctccgcagcaaagcacgtggctagaaaa acaggctacggcatgggctatctcaccactactactactactactgtgctcacagagaga agcttcctggaagaagatccgttatatattgcgtatgcagacatgatggcaaagagttgt gcagaggatgaagaggaggaagaagaggaagaggggaaagagaagacatttgaggagaag gagatggagaaacagaagatcttgtaccagcaggccaggctccacgcccgcggggctgct gagatggtgctacagatgatcagcgccagtaaaggtcgactaggtcctatggtgacctgc accctcaaactgggcatctccatcctcaacggaggcaacgtgctggtccagcagaaaatg ctggattatctgaaagagaaaagagatgcaggctttttcaagagtttgtcaggcctcatg cagtcctgcagtgtcctggacttaaatgcctttgagagacagaataaagcggaaggtcta gggatggtgacagatgaaggatcctgttccaaagtgctgacgaatgatgacttcaccaaa gatctcttccggtttttacaactgctctgtgaggggcacaacggggatttccaaaacttc ctgagaacacaaacaggaaacacgttgacagtcaacattatcatcagcacagtggactac ctgctacggcttcaggaatctatcagtgacttctactggtattattctgggaaagacatt atcgacgaggcagggcaggtcaacttctccaaagccttagctgtcgcaaagcagatcttc aactcgctcactgagtacatccagggcccatgtattgggaaccagcagagtctggcccac agcagactgtgggatgcggtggtgggattcctgcatgtgtttgccaacatgcagatgaag ctgtcccaggactcgtgtcagattgagctgctgaaggagttgatggatcttcagcaggac atggtggtgatgatgctgtcactgctggagggcaacgtggtaaatggaacaattggaaag cagatggtggacactctggtggagtcctccagcaacgtagagatgatcctcaagttcttt gacatgttcctcaagatcaaggacctgaccacctctgacaacttcagggagtacgacccc gataacaagggggtcatctccaaaaaagatttccagaagtccatggagaaccagaagcag tacacccagtcggagattgagttcctcctctcctgcgccgaggccgacgagaatgacatg ttcaactacgaggagtttgtggagcggttccacgagccggccaaagacattggcttcaac atagccgtgctgctcactaacctctctgagcacatgcctcacgatccccgtctggccacc ttcctggaaccagctgagagcgtgctgaactacttcgagccgtacctgggccgcatcgag atcatgggcggagggaagcgcatagagagggtctactttgagatcagcgagtccagccgc acgcagtgggagaagccacaggtcaaagagtccaagagacagttcatcttcgacgtggtc aacgagggtggagagagcgagaagatggagatgtttgtgaacttctgcgaagacaccatc tttgagatgcagctggcgtctcagatctcggagccagaagtggcggagcgcccggaggag gaagaggaggaggtgcacaacttgctagaagagctggctgagcaagaggaggagagagag ctggaggcttcctcagctttcaccatggtctgtgtcgccgccaagaagaagatctccaac ttccgacagatgctgaccttcaagaccctcaagaagcagtacaagaagaccaagaagctg agcatgaaggaggtgatcattgggttcttctcctttttctggacgctcttcgcagggttc ttcaaggggatctacagcctcatctttggattcttccacctcatctggtcatccatgttc ggaggcggcctcgtcgaaggagccaagaacatgaaggtgacagacatcttgggcaacatg cccgatcccacccagttcggtatccacggcgacgtgttggagacggaaaaggtggaggtg ggagattcggtgtcgggcggaacagaccaggccatcaaaccgtcggacaaggcagagcag gacatcttgatggagatgattaatcccacgccaaagaaaggggaagggttaaaacatgtt gatcctggactgggagacgtctctgagactcctgagacctccaccgctgtggagaagaag aaagctgcttctgaaccaatggagttggaaccagagaaagcagacacagagaagaaggaa aaggaagacaaggtcaaagcggagcagcctaaagaggaagtggctcaggataagcccgtt cccaagtccagaaacagccaatcaaaggaggctcctacttccttctttgccagcttcttg tctgggttggaggtctaccaggccaagatgctgaacacgttggctcggaacttctacaac atgcgtttcctggctctgtttgtggcgtttgccatcaacttcatcctactgttctacaag gtgactgctgctgaggatgatgaggatgactcttggactagttctgatgacgatgatgaa ggtggcgaggagtactttgtcctggaggagagtacaggctacatggctcctattctgtgt ttcctggctgtgttccacactgccctctctatcctctgtttggttggctactactttctc aaggtgcctctggtggtgtttaagagagagaaagggatcgccaggctgttggagtttgaa ggtctctacatcacagagcagccggcagacgatgacatcacgggccagtgggaccgcctc gtcatcaacaccccatccttccccaataactattgggacaagtttatcaaacggaaggtc attaataagtatggagacctgtatggagctgagcggatagctgagctgttgggtctggat aagagcgccctggacttcgaccctactcaggagaccgtggtggaggaggcttctcttgta tcctggttgagctctatcgacaccaagtaccacatctggaaaatgggagtggtgctgact gataactcgttcctgtacctgatctggtacgccaccatgtccatcctggggcactataac aacttcttcttcgctgcccatctgctggacatcgccatgggcttcaagaccctccggacc atcctgtcctccgtcactcacaacggaaaacagttggtgctgactgtaggtctgttagcg gtggtggtgtatctgtacactgtggtggccttcaacttcttcaggaagttctacaacaag agcgaggacgaggacgcacctgacatgaagtgtgacgacatgatgacttgctatctgttc cacctgtacgcgggggtgagggccggcggtggtatcggtgatgagctcgaggacccggcc ggagacccctacgagctgtggcgtatcctcttcgacatcaccttcttcttcttcgtcatc gtcatcctcctggccatcattcagggtttgattattgatgcgtttggggaactgagagac cagcaggagcaggtgaaggaggatatggagactaaatgcttcatctgtggaattggaaac gactactttgacacgacaccccacggctttgagacccacaccttacaagaacacaacctg gccaactacctcttcttcctgatgtacctcatcaacaaggacgagactgaacacactggt caggagtcgtatgtgtggaagatgtaccaggagagatgctgggacttcttccctgctgga gactgtttcaggaagcagtatgaggacctgcttgggtag

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