Oncorhynchus mykiss (rainbow trout): 110498363 Help Entry 110498363         CDS       T07259                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism omy  Oncorhynchus mykiss (rainbow trout) Pathway omy04020   Calcium signaling pathway omy04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:omy00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110498363    04020 Calcium signaling pathway     110498363  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:omy04040]     110498363 Ion channels [BR:omy04040]  Voltage-gated cation channels   Ryanodine receptor    110498363 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Med16_bridge Motif Other DBs NCBI-GeneID:  110498363 NCBI-ProteinID:  XP_036810794 Ensembl:  ENSOMYG00000020212 LinkDB All DBs Position 19:complement(44232163..44399357) Genome browser AA seq 4893 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIHKENRKFCLTAEGLGNRLCYLEPTSEAKYVPP DLCICNFVLEHSLSVRALQEMLAKTGQNSEGAAQGGGHRTLLYGHAILLRHSFSAMYLTC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPTCSGSNVEEGYLLGGHVLRLFHGHDEVLTIPGSDQS DEQQRIVNYETGNAGAKARSLWRLEPLRISWSGSHIPWGQPFRLRHLTTGHYLSLTEERG VVLQDREKSDTSSTAFCFRASKEKLESSPKRDIEGMGMAEIKYGDSICFVMHVATGLWLS YQAPDVKSSRLGPLKRRAFLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSHFIRDL DCLGGKNRASVALPIEEVHQTLYDLITYFQLPDAELEHEEKQIMLRSLKNRQNLFKQEGM LTLVSCCIDRLNVYNSAAHFGECAGAEAGASWKEILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILTESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGVSEGSAQYKKWY YELTIDQVDHFLTSDPSHLRVGWATNKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRISRAVASINQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNIDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKIKVEPVKEYKRDMEGVRDLLGTT QFMSQASFIPTPVETSQIVMLPYLEKVRDRLAENIHELWAMNKIELGWSYGKIRDDNKRH HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVVQVNANAEEDLKKIKLPKNYMMSN GYKPTPLELSDVKVTPGQELLVEKLAENAHNVWAKDRIKQGWTYGIQQDVKSKRNPRLVP YSLLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQDGGHVVERLSIDKIRFFRVERTYAV LTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYKGHRLNMGSRFFGRCW QAGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQVGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPKNNNHIMVTRIDGT IDSPPCLKVSHRTFGTQNSNGDMVYCRLSMPVEFHTFFKTSPVMDMNGVHDEHESLKLKH RHPLKSMRHSHDGIRGTDYSNITTYYYSVRVFAGQDPSCVWVGWVTPDYHYYSNHFNLSK NRTVTVTLGDERGRVHESVRRSNCYMVWGGDATSSGHSSSRSNVDLEIGCLIDLATGLVT FTVNGKELGTSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNTMPLSAAIFKSEHKNPV PQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWVVQCLEPLQMLAVHIPEENRCV DIMELSEQEDLRTFHYHTLKLYCAMCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLR EGFYNVLISVHLETAKEARLMMNNEFIIPVTAETRSIRLFSDATKHHSPPGVGLSTSLKP RLNFYPPCFISTKREQQLYSPQIPLDALKEKAITMLTEAVQGGGHHIRDPVGGSVEYQFV PILRLIGTLLTMGVLGSQDVHKILLLIDPNVFAEHHEEVATAVTEAAEKEGLTAAEEKAV EAGEEEAAKEAKQPIKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSK LQYNQKFRYNELMLALNMSAAITAKKTKEFRSPPQEQINMLLNFSTGEDCPCPEDIQEEL YAFHNELRLHCGIPMEEEEDDQDTSIKGRLLALVYKIKGQPLKTEEEPTEQEQQAPSNLK ELISQTMVSWAQECHVQDPELVRVMFSLLRRQYDSIGELLRAMRKSYTISAASIQDTINL LASLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKIFYQHPNLMRVLGMHETVMEVMVNVL GGGKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTP LDVAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLDKGYPDIGWNPIEGERYL SFLRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISDNPAV DLPSSAQGVSSDASAEDDEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALR IRAILRSLVPTEDLVGIISIPLKMPVVHKDGTVTEPDMAASFCPDHKAPMVLFLDRVYGI EDQSFLLQLLDVGFLPDLQASASLDTEVLSTTETALAMNRYIGSAMLPLLTRCAPHFAGT EHYAVLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKYLRPSMLQHLLRRLVFDVPL LTEYCKMPLRLLTNHYEQSWKYYCLPSGWGSYGMASDEELLLTKKIFWGVLDSLSQRKYD ADLFKMAMPCLSAISGALPPDYIDATISTTLEKPVSVDAQGNFDPKPISTANISLPEKLE HVANKYAEHSHDKWSAEKVMLGWRYGDCIDEKAKTHPLLRTYKGLTEKEKDIYRWPVRET LKSMLAMGWNIDRTKDGETMSLRESEKMRKISQSSSHANGFNPTPIDTINVVLSRELQGM VEVVAENYHNIWAKKKKNDLGIRGGATHPLLVPYDTLTAKEKARDKEKTQDLFRFLQING YAITRGLKDMEQDSSSMEKRFAYKFLKKLLKYVNSAQEFIAHLEAMATSGKTDKSPHEQE IKFFAKVLLPLIDQYFKNHCLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRI SLFGSDSTTMVSVLHILAHTLDTRTVMKSGSELVKAGLRTFFENAAEDLEKTLENLKLGK FTHSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYA LGTGKNIYVERQLPALGECLATLAGAMPVAFLEPLLNKHNPCSVFNTKTARERAILGMPD AVEEMCPEMPRLDVLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWEKGPESLAS PHSGGSVGGSVFSTTVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIITKARA VLLKSHFLPTLEKLKKKTVKVVTEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPM LIRYVDNNRSRWLKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLT GDSKIKMSKSGGQDQERKHKRKRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLA KTRYILKDTDDEVKEHLRQNLHLQEKSEDPAVRWQLNLYKDVMVKNEGPPDPERTVFRVQ SISAAVFHLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLGY QRIWIETETYSFEEKLVQDLAKTQLKVEEEEEEEAEMQPDPLHQLILHFSHNALTERSSL EEDPLYIAYADMMAKSCAEDEEEEDEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQ MISASKGSLGPMVTFTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSLSGLMQSCSV LDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQN FLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALAVAKQI FNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIDLLKELLDLQK DMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSDNFKEYD PDSKGVISKKEFQKSMENQKQYSQSEIEFLLSCVEADENDMFNYEEFVERFHEPAKDIGF NVAVLLTNLSEHMPHDARLATFLDLAESVINYFEPYLGRIEIMGGAKRIERVYFEISESS RTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDSVERLE EDEEDSQSVEEEEEEEEEERMMESHSAFTNSCVSMRKNLSSFRQLLTFKSMRRQYRNFRK MSVREMVRGLFSFFWKIITGLFRFLYNLVWGFFHILWSSMFGGGLVEGAKNMKVTDILGN MPDPTQFGIHGDVLEAEKMEASEASSVAEMVQMAQVDKAEADLMAELLNIQTKSQGGKHA AEPGLGDMGEVVGVDAPSLATAVKQKKAKEASTMEPANGDHKAKPEKADPDDEEKKDKAK EETPPESPPEEEKKAPKKRPGLKKEPPEAFMARFFSGLEIYQTKMLNYLARNFYNLRFLA LFVAFAINFILLFYKVTGDDGDDDDPDPWNGGGGTDEEEDEGGMEYFVLQESTGYMAPTL RFLAILHTVISFLCVVGYYYLKVPLTVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDR LVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETVVKEASL VSWLSSVDTKYQCWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDENQPDMKCDDMMTCYL FHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHT GQESYVWKMYQERQWDFFPAGDCFRKQYEDQLG NT seq 14682 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggtgaaggggaagatgaaattcagttcttgagaactgatgatgaagtg gtgctccagtgtgtcgcctgcatccacaaggagaatcgcaagttctgcctgactgcagag gggctcggcaatcgactgtgctacctggaacccacatcagaggcaaagtatgtccctcca gacctgtgcatctgtaactttgtgctggagcattctctctctgtgcgggccctgcaggag atgctggctaagactggccagaacagtgagggggcggcccaggggggcggacacaggaca cttctgtatggacacgctatcctcctgaggcactccttcagcgctatgtatctgacctgt ttaaagacatcaaggtcacagacagataagctgtcctttgatgtggggctgcaggaggac tcaacaggtgaagcctgttggtggaccatccatcctgcctccaaacagagatcagagggc gagaaagtgcgcatcggtgatgacctcatcctcgtcagcgtgtcatcagaacgatacctt cacctgtccatctccaatggcaacatccaggtggacgcgtccttcatgcagactctgtgg aacgtccaccccacctgctccggcagcaacgtggaggagggttatctgctgggtggccat gtgttgcgtctgttccacggtcatgatgaagttctgaccatcccaggttccgaccagagt gatgagcaacagcggatagtgaactatgagacggggaatgcaggagcgaaggccaggtct ctgtggaggctggagcctctgagaatcagctggagcgggagtcacattccctggggccag cccttccgtctccgccacctcaccacggggcactacctgtccctgacggaggagagggga gtggtgctgcaggaccgggagaagtctgacacatcctccactgccttctgctttagagcc tccaaggaaaagctggagtcgagtccaaagcgggacatcgagggcatggggatggcagag attaagtatggggactcaatctgcttcgtcatgcatgtggctacaggactctggctgtcc taccaggcgcctgatgtaaaatcatctcgcctgggccctctcaagagacgggccttcctt cactctgagggtcatatggatgatgggctgaccttgcagcggtgtcagcacgaagagtcc cgtgctgctcgcatcatccgtaacaccacccgcctcttcagtcacttcatcagagaccta gactgtctggggggtaagaaccgtgcatcagtagccctgcccatcgaggaggtccaccag actctctacgacctcatcacctacttccagctgcctgatgctgagctggagcacgaggag aaacagatcatgctgcgctctctcaagaaccgacagaacctcttcaaacaggaaggcatg ctgactctggtgtcctgctgcatcgaccgtctcaacgtgtacaacagtgcagcccacttt ggggagtgtgccggggcagaggctggggcttcctggaaggaaatcctcaacttgctctat gagctgctggccgcgctgatccgaggcaacaggaacaactgcacccagttctccaacaac cttgactggctggtcagcaagctggagagactcgagtcctcctcaggcatactggaggtt ctccactgcattctaactgagagcccggaggctctaaatatcatccagagaggacacatc aagtccatcatctccctgctctacaaacatggacgtaaccacaagattctggatgtgctc tgctccctctgtgtgtgtaacggggtggctgtaagagccaatcagaatcttatctgtgat cacctgctccctaaaagagatctgcttctccagacccgattggtcaatgacgtccaaagc atgaggcccaacatcttcctgggagtgagtgagggctcggcccagtataagaagtggtac tacgagctgacgattgaccaggtggaccacttcttgaccagcgacccctctcacctgcgt gtgggctgggccaccaacaagggttacgccccttaccctggtggaggggagggctggggg ggcaacggggtgggggatgacctctactcttacggctttgacggacttcatctctggtca ggtcgtatctcccgggcggtggcttctattaaccaacacatcctgacctctgaggatgtg gtgagctgttgtctggacctgggagcccccagcatctccttcaggatcaatggacagccc gtacagggcatgttcgagaacttcaacatcgatggactcttcttccctgttgtcagcttc tctgctggcgtcaaggtgcgtttcctgttgggcggtcgtcatggcgacttcaagttcctg cctccgtcaggctacgctccgtgttacgaggccctgctccctaaggagaagattaaggtg gagccagtgaaggagtacaagagggacatggagggggtccgagacctgctggggaccaca cagttcatgtcccaggcctccttcatacccacccctgtggagactagccagatcgtcatg ctgccatacctggagaaggtccgggacagactggctgagaatatccacgagctgtgggcc atgaacaagatagaactgggctggtcttatgggaagataagggacgataataagcggcat cacccctgccttgtggatttttccaaactgcctgaaacagaaaagaattacaacctgcag atgtcaactgaaaccttgaagaccctgctggcattaggctgccatgttgtccaggtcaac gccaacgctgaagaggacctgaagaagatcaaactcccaaaaaactacatgatgtcgaat ggttacaagcccacaccgctggagctgtctgacgtgaaagtgaccccaggtcaggagctc ctggtggagaaactggcggagaacgcccacaacgtgtgggccaaggacaggatcaaacag ggttggacctacggcattcagcaggatgtgaagagtaagaggaaccctcgcctggtgcca tattctttattagacgagcgcactaagaagtccaacagggacagcctccgtgaggccatc cgcactctgattggatacgggtacaacatcgaacctcccgaccaggatggcggccacgtg gtggagagactgagcattgacaaaatacgcttcttccgtgtggagagaacgtatgcggtg ctgacagggaagtggtactttgagtttgaggcggtgacgggaggtgacatgcgtgtgggt tgggccagacctggatgtaagccggatgtagagctgggtactgatgagctggctttcgtc tttgatggatacaagggtcatcgtctgaacatgggcagccgtttctttggccgttgttgg caggcgggggatgtggtgggctgcatgatcaacatggaggacaagtctatgattttcacc ctcaatggagagatcctcatcaccaacaagggctccgagctctgcttcgccgacttcgag acggaggacggttttatcccagtatgtagtctgggcctgtcccaggtgggtcgtatgaac ctggggaaggatgccagtacctttaagtactacacaatgtgtggtctccaggagggcttt gaacccttcgccgtcaacatgaaccgtgaggtcaccatgtggttcagcaaacgcctcccc acctttttcaatgtgccaaagaacaacaaccacataatggtgaccagaatagatggcacc atcgacagccctccctgtctgaaggtgagtcacaggacttttgggacccagaacagtaat ggtgacatggtatactgtcgtctgagcatgcccgtggagttccacaccttcttcaagacc agccctgtcatggacatgaacggagtgcacgacgagcacgagtccctcaaactcaaacac agacatccactgaagtccatgagacacagtcatgacggaataagaggaacagattacagc aacatcaccacgtactactactctgtcagggtattcgctggtcaggatccatcctgcgtg tgggtgggctgggtcaccccagactaccattactatagcaaccacttcaacctcagtaag aaccggacggtgacagttacccttggagacgagcgtgggcgggtccacgagagtgtgagg aggagtaactgctacatggtgtggggaggggatgccaccagctcaggccactcgtccagt cgcagtaatgtggacctggagataggctgcctcattgacctggccactggcctggtgacc ttcactgtcaacggcaaggagctgggcacctcctaccaggtggaacccaacacaaagctg tttcctgctgtgtttgtgcgaccgaccagccccaatctcttccagtttgagctggccaag ataaagaacaccatgcctctgtcggcggccatctttaagagtgagcataagaacccagtg cctcagtgccctccgaggctggacgtccagaccatcaactcagtgctgtggagccgcatg cccaacaccttcctaaaggtggagacagccagggtcagtgagagacacggctgggtggtg cagtgtctggagcccctccagatgctggctgtgcacatacctgaggagaacaggtgtgtt gacatcatggagctgtctgagcaggaggacctgaggacgttccactaccacaccctaaag ctctactgtgccatgtgtgcactgggcaatacccgtgtagcacacgccctctgcagccac ctagaccaatcccagctgctctacaccatcgacaaccagtacctgtcgggcatgctgcgt gagggcttctacaacgtcctgatcagtgttcatctggagacggccaaggaggcccgcctc atgatgaacaacgagtttatcatccccgtcactgccgagactcgcagcatccgcctgttc tccgatgccaccaagcaccactctcctcccggcgtgggcctcagcacctccctgaagccc cggctcaacttctaccccccctgtttcatcagcaccaagagggagcagcagctgtacagc ccccaaatccccctggatgccctgaaggagaaggccatcaccatgctgaccgaggccgta cagggcggtgggcatcacatcagagaccctgtagggggcagcgtggagtaccagtttgtg cccatcctgaggctgattggcacgctgctcaccatgggcgtgctgggcagtcaggacgtt cataagatcctgctgcttatcgaccccaacgtgttcgcggagcatcacgaggaggtggcc accgcggtgacggaggccgcagagaaggagggactgacagctgccgaggagaaggcggtg gaggccggggaggaggaggctgccaaagaggccaagcagccaatcaaaggtctgctggag aagaggctgcctgagccagtcaaacgacagatgtgtgagctgcttcactacttctgtgac tgtgagctgaagcatcgcatcgaggccatcgtgtccttctcagacagctttgtctccaag ctgcagtacaaccagaagttcaggtacaacgagctgatgctggccctcaacatgtctgct gccatcaccgccaagaagaccaaggagttccgctcccctccccaagaacagattaacatg ctgttgaacttcagtacgggggaggactgcccgtgtccagaggacattcaggaggagctc tatgccttccacaatgagctgcggctgcactgtggaatccctatggaggaagaggaagat gaccaggacacgtctattaaaggtcgtctgctggccctggtctacaagatcaaaggtcaa cctctgaagactgaagaggagcccacagagcaggaacaacaagccccctccaacctgaag gagttgatctcccagaccatggtgagctgggctcaggagtgccacgtccaggaccccgag ctggtcagagtgatgttcagcctgctgaggagacagtacgacagcattggagagctgctc cgggccatgaggaagagctacactatcagtgctgcctctatacaggacaccatcaacctg ctggcctctctgggtcagatcagatcactgctatccgtacgcatgggcaaggaggaggag aaactcatgatcgacggtctgggtgacatcatgaacaacaagatattctaccagcacccc aacctgatgcgtgttctaggcatgcatgagacggtgatggaggtgatggtcaacgtgctg ggaggaggcaagtcccaggagatagcgttccccaagatggtggccagctgctgtcgcttc ctgtgttacttctgcaggatcagtcgtcagaaccaaaaggccatgtttgaccacctcagc taccttctggagaacagcagcgtaggccttgcatccccagccatgagaggctccactcct ctagacgtggctgcctcctctgtgatggacaacaacggcctggccttggccctggaagag cccgacctggacaaggtggtgacgtacctagcaggctgtgggctccagagctgtcccatg ctgctggacaaaggttaccctgacatcggctggaaccccattgagggtgaacgctacctc tccttcctgcgcttcgctgtatttgtcaatggtgagagtgtggaggagaactccagtgtg gtggtgaagctactgatcaggcgtccagagtgttttggcccggctctgagaggagagggg ggtaacgggctgctggcagccatgaaggaggccatcaaaatctcagataaccctgctgtg gacttgccctcctccgcccagggggtcagctctgacgcgtctgctgaggacgatgaggag gaagaggtggtgcatatgggcaatgccatcatgtccttctactctgccctcatcgaccta ctgggacgctgtgccccagagatgcacttgatcaacaagggtaaaggggaagccctgcga atccgtgccatcctgcgctcccttgtgcccactgaagacctggtgggcatcatcagcata cccctaaaaatgcctgtcgtccacaaagacggcactgtgacagagcctgatatggcagcc agtttctgcccggaccacaaggcccccatggtgctgttcctggaccgggtctatggtatt gaggaccaaagcttcctacttcagctgctggacgtgggcttcctgcccgacctgcaagcc tctgcttctctggacacggaggtactcagcaccacagagacagctctggccatgaacagg tacatcggctctgccatgctgcccctgctcacccgctgtgccccccacttcgctggcaca gagcactatgccgtgctcatcgactccacgctgcacaccatctacaggctgtccaagggc cgctcgctcaccaaggcccagagagacgctatcgaggagtgtctgctggccgtctgcaag tacctccgtccctctatgctgcagcatctcctgcgacgcctcgtctttgacgtgcccttg ctgacggagtactgcaagatgcctctcaggctcctgaccaaccactacgagcagagctgg aagtactactgtctgccatctggctggggcagctacggcatggcctcagacgaggagctg ctcctcacaaagaagatcttctggggcgtcttggattcgctctcacagaggaagtacgat gcagatctctttaagatggccatgccctgtctgagtgccatatctggggccttaccacct gactacatagacgccaccatcagcaccaccctggagaagcctgtgtctgtggacgctcag ggcaacttcgaccccaaacccataagcacagccaacatatctcttccagagaaactggaa cacgttgccaacaaatatgctgagcattcccatgacaaatggtcagcagagaaggtgatg ttgggatggaggtatggggactgtatagatgagaaggccaagactcaccctctactcagg acctacaaaggtctaacagagaaggagaaggatatctacaggtggcctgtgagggagact ctgaagagcatgctggctatgggctggaacatcgacaggaccaaggatggagagaccatg tccctacgggagagtgagaagatgcgcaagatctcccagtcctcctctcatgctaacggt ttcaacccgaccccaatagacaccatcaatgtggttctgtctagagagttacagggcatg gtggaggttgtggctgagaattatcacaacatctgggctaagaagaaaaagaatgacctt ggaattagaggtggggcaactcaccctctgctggtgccctatgacaccctgaccgccaaa gagaaggcccgggacaaagagaagacccaggacctgttccgcttcctgcagatcaacggc tacgccatcaccagaggtctgaaggacatggagcaggactcttcctccatggagaagagg tttgcctacaagttcctcaagaagcttctgaagtatgtgaactcagcccaggagttcatt gcccaccttgaggccatggctaccagtgggaagaccgacaagtcgcctcatgagcaagaa atcaagttttttgccaaagtcctcctccctctgatagaccagtacttcaagaaccactgt ctctacttcctgtcttctcccagtaagaacctgagcagcagcggctacgcctctaataag gagaaggagatggtcaccagcctgttctgtaaactggcagctcttgtcagacacaggatt tccctatttgggagtgactccaccaccatggtgagcgttctccacatcctggcccacaca ctggacaccaggacggtgatgaagtctggctcagagctggtgaaggcggggttaaggacg ttcttcgagaacgcagcggaggacttggagaagacacttgagaacctgaagttggggaag ttcacccactcccgctcacagatgaagggcgtgtcccagaacatcaactacaccacggtg gcactactgcccatcctcactgccctgtttgaacacatcacccagcaccactttggagtg gacctgctcttggatgatgtccaagtgtcctgctatcgtatcctgaccagcctctatgcg ctcgggactgggaaaaacatctatgtggaaaggcagctgccggccctgggggagtgcctg gccaccctggcaggggccatgcctgtggccttcctggagcccctgctcaacaaacacaac ccctgctctgtgttcaacaccaagaccgccagagaacgcgccatcctgggcatgccagac gcggtggaggagatgtgtccggagatgcctcgtctagacgtcctgatgaaggacatcaac gacatgtctgagtctggggcgcgctacacagagatgccccacgtcatcgaggtggtgcta cccatgctgtgtaactacctgtcctactggtgggagaagggcccagagagcctggcgtct ccgcacagcgggggaagtgttgggggcagtgtcttctccaccaccgtcacctcagaacac ctcagcctcatcctgggaaacatcctgaagatcctcaacagcaacctgggcatcgacgag gcctcctggatgaagaggatcgcagtgtacgcccagcccatcatcactaaggccagggct gttctgttgaagagtcacttcctgcctacactggagaagctgaagaagaagacagtgaag gtggtgacggaggaggagctactgaaggctgacagtaagggagatacccaggaggctgag ctgctcatcctggatgagtttgctgtgctctgcagagacctctacgccttctacccaatg ctcatccgctatgtagacaacaacaggtcgagatggctgaaagaaccagacgctgactcc aatgaactcttcagaatggtggctgagatcttcatcctctggtgcaaatcacataacttc aaaagggaagagcagaactttgtggttcagaatgaaatcaacaacctgtcattcctgact ggtgatagcaagatcaagatgtcaaagtcagggggtcaggaccaggagaggaagcataag aggaaacgaggagagttctactccatccagacctccctgatcgtggctgccctgaagaag atgctgcccattggactcaacatgtgcacccccggggaccaggagctcatctccctggcc aagacacgctatatcctgaaagacacagatgatgaagtgaaggagcatttgcggcagaat ctgcaccttcaagagaagtcagaggaccctgcagtgcggtggcagctgaacctgtataag gatgtgatggtgaagaacgaggggcctccagaccctgagagaacagtgttccgggtccag agcatctcagctgcagtctttcatctggagcaggttgagcagccgttgaggtctaagaag tgtgtgtggcagaagctgctgtccaagcagagaaagcgtgcggtggtggcctgcttccgc atggctcctctctacaacctgcccaggcatcgctctattaacctcttcctcctgggctat cagagaatatggatagagacagagacgtactcttttgaagagaagctagtgcaggacctg gcaaagactcaactgaaggtggaggaggaggaagaggaggaggcagagatgcagccagac cctcttcatcagctcatcctgcatttcagtcacaatgcgctcactgagcggagttctttg gaagaggatcctttgtatattgcatatgcagacatgatggcaaagagttgtgcagaagat gaagaagaggaagatgaaggaaaagagaaaacgtttgaggaaaaagagatggagaaacag aagactctgtaccagcaggccagactgcatgacagaggagctgctgagatggtgttacag atgatcagtgccagcaaaggttcacttgggcccatggtgacctttaccttgaagctgggc atctccatactcaacgggggcaacatactggttcagcagaaaatgcttgactatctgaag gaaaaaagagatgctggctttttcaagagtttatcaggactcatgcagtcttgcagtgtc ctggatttgaatgcattcgaaaggcaaaacaaagcagaaggtcttgggatggtgactgag gaaggatcaatcaacgtgagtgagcggggttccaaggtactgcagaacgatgagttcact aaggatctgtttaggtttctgcaattgctctgcgagggacacaacaacgacttccaaaac ttcctgcggactcagacagggaacacaaccacagtaaatatcatcatcagcactgtggac tacctgctccgtctgcaggaatccatcagtgatttctactggtactactctgggaaagac atcatggatgaggctggccagcggaacttctccaaagccctggctgtggccaagcagatc ttcaactctctcactgagtacatacagggcccgtgtattgggaaccagcagagtctggcc cacagcaggctatgggatgcagtggtgggcttcctgcatgtgtttgccaatatgcagatg aagctctcacaggactcaagtcagattgacttattgaaggagctgctggacctgcagaag gacatgattgtgatgatgctctcccttctggaaggtaatgttgtcaacggaaccattggc aaacagatggtggacaccctggtggagtcctccagcaatgtagagatgatcctcaagttc ttcgacatgttcctcaaactcaaagacctgacctcctcggacaacttcaaggagtacgac ccggacagcaagggagtgatctccaagaaggagttccagaagtccatggagaaccagaag cagtactcccagtcagagattgagttcctgctctcctgcgttgaggctgacgaaaacgac atgttcaactacgaggagtttgttgaacgttttcatgaaccggccaaggacattggtttt aacgtggcggtcctgctcaccaacctatcagaacacatgcctcacgacgcccgtctagcc accttcctggacctggctgagagtgtaatcaactacttcgagccctacctgggccgcatc gagatcatgggcggggccaagcgcatcgagagggtctactttgagatcagtgagtccagt cgtacgcagtgggagaaaccccaggtcaaagagtccaagagacagttcatctttgacgtg gtcaacgagggcggggaaagcgagaagatggagctgtttgtcaacttctgtgaggacacc atctttgagatgcaactggcctcccagatctctgagcctgactcagtggagcgtctcgag gaggatgaggaagacagccagagtgtggaggaggaagaggaggaggaagaggaggagaga atgatggagtctcactcagccttcacaaactcctgtgtctccatgaggaagaacctgtcc agcttccgccagctgctcaccttcaagagcatgcggcggcagtacaggaatttcaggaag atgagtgtgagggagatggttcgagggttattctccttcttctggaagataatcacgggc ctcttccgcttcctctacaacctggtgtggggcttcttccacatcttgtggtcctccatg tttggtgggggcctggtggaaggggcaaagaacatgaaggttacagacatcctggggaac atgcctgaccccacacagtttggtatccatggcgatgtgctggaggcagagaagatggag gcgagcgaggcatcgtcggttgcagagatggtccagatggcccaagtggacaaggcagag gccgacctgatggctgagctgctcaacattcaaaccaagagccaggggggcaagcacgca gccgagccaggtctgggggacatgggtgaagtggtgggggtcgacgccccctctttagcc actgccgtcaaacagaagaaggccaaggaggcttctactatggagcctgccaatggagat cacaaagccaagccagagaaggcagacccagatgacgaggagaagaaagacaaagccaaa gaggagactccacctgagtccccaccagaagaggagaagaaggcccccaagaagagaccg ggactaaagaaagagcccccagaggccttcatggccagattcttctctgggctggagatc taccagaccaagatgttgaactatctggccagaaacttctacaacctgcgtttcttagcg ttgttcgttgctttcgccatcaactttattctgctcttctacaaagtgactggcgatgat ggggatgacgatgatccagacccctggaacggtggtggaggtactgatgaagaggaggat gaaggtgggatggagtattttgtcctgcaggagagcaccggctacatggcacctacactg cgcttcctggccatactacacacagtcatctctttcctgtgtgtggtgggatactactac ctgaaggtgcctctgacggtgttcaagagagagaaggagatcgccaggaagctggagttt gacggcctctacatcacagagcagccgtcagacgatgacatcaaaggacagtgggaccgc ctcgtcatcaacaccccttccttccctaataactactgggacaagtttgtgaaacgcaag gtgatcaataagtatggagatctgtatggagcagagaggatagcagagctgctggggctg gataagagtgctctggacttcaaccccacagaggagacagtggtgaaggaggcatcgctg gtgtcctggttgagctctgtcgacaccaagtatcaatgctggaaaatgggtgtggtgttt acagacaattcgttcttgtacctggtgtggtacaccaccatgtccatcctgggtcactac aacaacttcttcttcgctgcccatctgctggacatcgccatgggcttcaagaccctccgg accatcctgtcctcagtcacccacaatggcaaacagctggttctgactgtaggtctactg gcggtggtggtgtatctgtacactgtggtggccttcaacttcttccgcaagttttacaac aaaagtgaggatgagaaccagccggatatgaagtgtgacgacatgatgacttgctacctg ttccacatgtatgttggtgtgagggcagggggtggcatcggagacgagatagaagaccct gcgggcgacccctacgagctctaccgcatcctcttcgacatcaccttcttcttcttcgtc attgtcatcctgctggctatcatccagggtctgatcattgatgcttttggagagctgaga gaccaacaggagcaagtgaaagaggatatggagaccaaatgtttcatctgtggcatcggc aatgactactttgacacgacgcctcacggctttgaaacacacaccttacaagagcacaac ttggccaactacctgtttttcctgatgtacctcatcaacaaagatgagacagaacacact ggccaggagtcatacgtgtggaagatgtaccaggagaggcaatgggactttttccccgct ggagactgtttcagaaagcagtatgaggatcagcttggatag

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