Ochotona princeps (American pika): 101532988 Help Entry 101532988         CDS       T07609                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism opi  Ochotona princeps (American pika) Pathway opi04020   Calcium signaling pathway opi04371   Apelin signaling pathway opi04713   Circadian entrainment opi04921   Oxytocin signaling pathway opi04970   Salivary secretion opi05010   Alzheimer disease opi05012   Parkinson disease opi05020   Prion disease opi05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:opi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101532988 (RYR3)    04020 Calcium signaling pathway     101532988 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101532988 (RYR3)   09154 Digestive system    04970 Salivary secretion     101532988 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     101532988 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101532988 (RYR3)    05012 Parkinson disease     101532988 (RYR3)    05020 Prion disease     101532988 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     101532988 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:opi04040]     101532988 (RYR3) Ion channels [BR:opi04040]  Voltage-gated cation channels   Ryanodine receptor    101532988 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  101532988 NCBI-ProteinID:  XP_036351465 LinkDB All DBs Position 17:complement(47530679..47864889) Genome browser AA seq 4533 aa AA seqDB search MNHLYFDTDCLDLNLTQPNLIPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGG GHRTLLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQ RSEGEKVRIGDDLILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYL LGGHVVRLFHGHDECLTIPSTDQNDSQHRRIFFEAGGAGTRARSLWRVEPLRISWSGSNI RWGQAFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDI EGMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQ RCQLEESQAARIIRNTTALFSQFVSGNNRTAAPVALPIEEVLQTLQDLIAYFQPPEEEMQ HEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILN LLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAE GHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLIND VTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGE GWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASTNQHLLKSEDVVSCCLDLGVPSISFRIN GQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEK MRLEPVKEYKRDAEGIRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHE LWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIA HVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVNKLAENAHNVWAKDR IKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQEL ADPAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADD QAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAF ADYEIENGFVPICSLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFS KRLPTFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHS SFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYSIRIFAGQDPSCVWVGWVTPDYHLYSEK FDLNKNCTVNVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLVDLA MGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNTMPLSAAIFKSE EKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPE ENRCVDILELCEQQDLMQFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYL PGLLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTRNIRLYPDESKRHGLPGVGPR TCLKPSFRFSTPCFVMTNEDHQKQSPEIPLEILKTKALSMLTEAVQCSGAHIRDPVGGSV EFQFVPVLKLIGTLLVMGVFGDDDVRQILLLIDPSVFGEHSAETEEGTEKEEVTQVEEKA VEAGEKTNKEARKEAPIKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYV SKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIRE ELYDFHEDLLLHCGVPLEEEEEEEEDTSWTGKLRTLVYKIKGPPKPEKQQPTEEEQRCPT TLKELISQTMIRWAQEDQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISHASVSDT INLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMV NVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGS TPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGER YLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQAAIKISESP ALDLPSQGYKREVSSEDDEEEEETVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAI RIRSILRSLVPTEDLVGIISIPLKLPSLSKDGSVSEPDMAANFCPDHKAPMVLFLDRVYG IKDQTFLLHLLEVGFLPDLRASASLDTVALSTTEAALALNRYICSAVLPLLTRCAPLFAG TEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVP QLNEYCKMPLKLLTNHFEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHRKY DPDLFRMSLPCLSAIAGALPPDYLDTRITATLEKQVSVDADGNFDPKPINTVNFSLPEKL EYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARE SLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQTSQGNSYNPVPLDLSNVVLSRELQG MVEVVAENYHNIWAKKKKLELESKGGGTHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVN GVIVSRGIKDMELDAFSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQ EIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHR ISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLG KFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLY SLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNCYNPLSVFNTKTPRERSILGMP DTVEEMCPDIPQLDGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLH TSTGPCCSKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSH FIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAILCRDLYAFYPMLIRYVD NNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSK MSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAK SRYSYRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLKTEEPSNPEKTVERVQRI SAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQR FWIETEEYSFEEKLVQDLAKSPKVEEEEEEEMQKQPDPLHQIILHFSRNALTERSKLEDD PLYTSYSSMMAKSCQSGEDEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMIS ASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDL NAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLR TQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNS LTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMV VMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDG KGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVA VLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRLEEEE GDEESSYMLEMNEEEEEEKSLESASAFAMACVSVKRSITNLLRKATLKNLRKQYRNVKKM TMKELVKMFFSFFWMLFVGLFQLFFTILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDM PDPTQFGIHDDAMEAERTEVTEAGITPELAHFAKGEKGDTDIMSDLFGLHSKKEGGLKHG PEVGLGDLSEIISKDEPPTLESTVRKKRKAQAAEMKAAHGAEGKADSEKADLEDGEKEDK AKEEEQAEYLWAEVTKKKKRRRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRF LALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSLNEEEEEEAMVFFVLQESTGYMAP TLRALAVVHTIISLVCVVGYYCLKLKASLTIYQVTKSTCGTFSFWFFLMYLINKDETEHT GQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 13602 nt NT seq  +upstreamnt  +downstreamnt atgaatcacctgtactttgatacagactgcttggacctaaatttaactcagccaaatttg attcctcctgatctttgtgtctgcaattttgtgctggaacagtctctatctgtcagagcc ctgcaggaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcgcaaggaggg ggccacaggaccctgctttatggccatgcaatactcctgcggcactctttcagtggaatg tatctaacctgtttgactacgtcaagatctcagacagataaacttgcatttgatgtaggt ctgcgggaacatgccacaggagaagcttgttggtggaccatacatcctgcttccaaacaa agatccgagggagagaaagttagaattggagatgacctcatcctcgtcagtgtgtcctct gagagataccttcatctctcaatatcaaatggcaacatacaagtggatgcctcctttatg caaacactctggaatgtacatcccacgtgttcaggaagtagcatcgaagaaggatacctg cttggtgggcatgtggtacgtctttttcatggccatgatgagtgtttgacaataccatca acagatcagaatgactcccagcacaggaggatattctttgaagctgggggagctgggaca cgagccaggtcgctgtggagagtggaaccccttcggataagctggagtgggagtaacatc cggtggggccaggctttccgactccggcatctcaccacaggccactacctggccttgaca gaagaccaaggcctcctcctgcaagacaggggaaagtcagacacaaagtccacagccttc tccttccgggcgtcaaaggaaatcaaggagaaattggattctagtcacaagcgtgatata gaaggcatgggagttccagaaatcaaatatggagactctgtctgttttgttcagcacata gccagtggtctgtgggtgacttacaaagcacaagatgccaaaacatctcgcctgggacct cttaaaagaaaggtcatactgcatcaggaaggtcatatggatgatggtttaacactgcag agatgccagcttgaagagtcccaagctgctcgtatcatccggaacacgactgccttattc agccagtttgtcagtggcaacaatcgcacagctgcccctgtcgccctgcctatagaagag gtcctgcagaccctccaggacttgattgcctacttccagcccccagaggaggagatgcag catgaagacaagcagaacaagctccgctctctgaaaaacagacagaatcttttcaaggaa gagggaatgttggccttggtgctaaattgcattgatcgcttaaacatctacaatagcgta gcacactttgcaggaattgccagggaagagagcggcatggcttggaaagaaatcctgaac ctactgtacaaattgctggctgctcttattaggggaaacagaaacaactgtgctcaattc tccaacaaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatc ttggaagttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagag ggccacatcaagtccatcatctccctgttggataagcatggacggaatcacaaggttctg gatgtcctgtgttccctctgtctctgcaatggggtcgcagtgagagccaatcaaaatcta atttgtgacaacttgctaccccggagaaacctgctcctgcagacgagactgattaacgat gtgaccagtatccgaccaaacatcttcctgggagtcgctgagggctcagcccagtacaaa aagtggtacttcgagctcatcattgatcaggtggaccccttcctcacagcagagcccaca cacctgcgagtgggctgggcctcctcctcgggctatgccccatacccaggaggtggagaa ggatggggaggcaatggtgttggtgacgacctatactcctatggctttgatggacttcac ctgtggtcaggacggataccgagagctgtggcttccaccaaccagcacctcctcaagtca gaagatgtggtaagctgttgccttgaccttggagtgcccagcatctccttccgtatcaat gggcagcccgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtg atgagcttttcagcaggtgtcaaggtacggttcctcatgggtggacgtcatggagaattt aaattcttgcctccttctggctatgccccttgctatgaagcattacttccaaaagagaag atgagattggagccggtcaaagaatataaacgtgatgctgagggcattagagatctgttg ggcaccacccagttcctctcccaagcttctttcattccatgccccatagacaccagtcag gttgtattgccacctcacctagagaagatccgagacagactggctgaaaacatccatgag ctttggggaatgaataaaatagagcttggttggacttttggcaagatacgggatgataat aaaagacaacacccctgccttgtggagttttcaaagctccctgaaactgagaagaattat aacctacaaatgtcaactgaaaccttaaaaaccctcctggccctgggctgccacatagct catgttaacccagctgctgaagaggatctcaagaaagtcaaactgcccaaaaactacatg atgtctaatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcca caagaaattctagtgaataaacttgcagaaaatgcacacaatgtttgggccaaagataga ataaaacaaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccccgt ctggtgccatatgcattactggatgagcgaactaagaagtcaaacagggacagcctgcgt gaagctgttcggacgtttgttggttatggatacaacattgagccatcagaccaagaacta gctgacccagctgtggagaaagtgagcatagacaagatacgatttttccgggtggaacgg tcttatgcagtgagatctggaaagtggtattttgaatttgaagtggtgactggaggagac atgcgggtcggctgggccaggccaggctgtcggcctgacattgaactgggggccgatgat caagcctttgtgtttgaaggcagcaggggccagcgttggcaccagggtagtgggtatttt gggcgtacttggcagccaggagatgtggtcggctgtatgattaacctggatgatgcttca atgatcttcacactgaatggggagctactgatcaccaataaaggctctgaacttgctttt gctgactacgagattgaaaatggatttgtgcctatctgctccctgggactgtctcagatt ggccgcatgaatcttgggacagatgctagtaccttcaagttttacaccatgtgtggtctc caggagggctttgagccctttgctgtcaacatgaaccgagatgttgcaatgtggttcagc aagcgcctcccaacgtttgtcaatgtgccaaaggatcatccacacattgaggtggtgagg attgatggcaccatggacagccccccatgcctcaaggtgacccacaagacatttggcaca cagaacagcaatgccaacatgatctattgccgtttgagcatgcccgtcgagtgccattcc tccttcagccacagcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaa gaaatactctctcatacaacaacacagtgttactactccatccgcatcttcgctggacag gacccctcctgcgtctgggttggctgggtgactccggactatcatctgtacagtgaaaag tttgacctgaataaaaactgtacagtgaatgtcaccctaggggatgagagaggccgggtc catgaaagtgtcaaacgcagtaattgctacatggtctggggtggggatattgtggccagt tcccaaagatcaagccgaagcaacgtggacctggagattggctgccttgtggatcttgca atgggcatgttgtccttttcagccaatgggaaagaacttggcacctgctaccaggtggag cccaataccaaagtgttcccagcagtcttcctgcaaccaacaagcacatctttgtttcag tttgaacttgggaagctgaagaatacaatgcccttgtcagcggccatatttaagagtgaa gagaagaacccagtcccacagtgcccacctcggctggatgtgcaaaccattcagccagtg ctctggagccgcatgcccaacagtttcctaaaggtggaaacagaacgggtgagcgagcgc cacggctgggtggtgcagtgtctggagccgctgcagatgatggccctgcacatcccagag gagaacaggtgtgtggacattctggagctatgtgagcagcaggacctgatgcagttccac tatcacacactgagactgtacagtgccgtgtgcgcactggggaacagccgagtagcctac gccctatgcagtcatgtggacctctcccagctcttctatgctattgacaacaagtatctg cctggcctccttcgatctggtttctatgacctgctcatcagcatccacctggccaatgct aaggaaagaaagctgatgatgaagaatgaatacatcattcccattaccagcaccaccagg aatatccgcctgtacccagatgagtccaagagacacgggctgcctggcgtgggcccgaga acatgcctcaagccaagcttcaggttctcgaccccttgctttgtcatgaccaatgaggac caccagaaacagagccctgagattcccttggagattctaaaaacaaaggcattgagcatg ctgacagaagcagtgcagtgcagtggggcccacatccgagaccctgttggcgggtctgta gagttccagtttgtacctgtactgaaactcatcggaaccctgctggtgatgggtgtgttt ggcgatgatgatgtccggcagatcctcctcctcattgacccctctgtgtttggcgagcac agtgcagagacagaggagggaacagagaaggaagaagtgacccaggtagaggagaaggca gtggaggctggggaaaagaccaacaaggaggccaggaaggaggctccaatcaaaggcttg ctgcagacccgattgcctgagtccgtcaagctgcagatgtgtgagctcctcagctatctc tgtgactgtgagctgcagcatcgggtggaagccattgtggcattcggtgacatttatgtc tccaagctgcaggcaaatcagaagttccgctacaatgagctcatgcaggccctaaacatg tctgcagccctgactgcccgcaagacgagggagttccggtcaccgccccaggagcagatc aacatgctgctcaactttcaactgggagaaaattgcccctgcccagaggagatccgggag gagctgtatgacttccatgaggaccttctccttcactgtggggttcccttggaggaagag gaagaggaggaagaagacacctcctggacaggaaagctccgcaccttggtatataaaatc aaaggccctcctaagccggagaagcagcagccaacagaggaagagcaaagatgccctaca acactgaaggaactcatctcacagacaatgatccgctgggcccaagaggaccagattcag gatgcagagctggttcgcatgatgtttaacctcctccggaggcagtacgacagcatcggg gagctgctgcaggccctacgcaagacctacaccatcagccacgcctctgtgagcgacacc atcaacctgctagctgccctaggccagattcgctcccttctgagcgtcaggatgggaaag gaggaggagctgctcatgatcaatggactgggggacataatgaacaacaaggtgttttac cagcatcctaacctcatgagagtgctgggcatgcatgagacagtgatggaggtgatggtg aacgtgttgggcacagagaagtctcagattgcttttccaaagatggttgctagctgctgc cgcttcctgtgctatttctgtcgcattagccgacaaaatcagaaggctatgtttgagcac ctgagttatctgttggagaacagcagtgtcggcctggcctccccgtcgatgagagggtcc accccattggatgtggcagcctcctctgtgatggacaacaacgagttagcactgggctta gaagagccagatcttgagaaggtggtgacctatttggcaggctgtggcctacagagctgt cccatgctactggccaaaggataccctgatgtcggctggaatcctatagaaggggaacga tacctgtccttcctgaggtttgctgtcttcgtgaacagtgaaagcgtggaagaaaatgct agtgttgtggtcaagctgctcatcaggcgtccagagtgctttggcccggccctgcggggt gaaggtggaaatggcctcttggcagcaatgcaggctgccattaagatctccgagagccca gcgcttgacctcccctctcagggatacaagagggaagtcagctcggaagatgacgaggag gaagaagagactgtgcacatgggcaatgcaattatgtccttctattcagcgctcatcgat ctgctgggccgctgtgctcccgaaatgcatctcatccagacaggaaaaggggaagccatc cggatccggtccatcctccgctccctggtgcccacagaggacctggtcggcatcatcagc atccccttaaaactgccctccctgagcaaagatggatcagtcagtgagccagacatggcg gccaatttctgccctgaccacaaggctcccatggtactgttcttggaccgtgtttatggt attaaggatcaaacttttctcctccacttgctggaggttggatttttaccagacttaaga gcttctgcctccctagatacggttgctctcagcaccacagaggcagcgctggcactcaat agatacatctgctccgccgtgctcccgctgcttacgaggtgtgcccccctctttgctgga acagaacactacacctctctgattgattccacactgcagacaatatacaggctttccaag ggacgatccctcaccaaggcacagcgggacaccatagaagaatgtctgcttgccatttgc aatcacttgaggccttccatgttacagcaactcctgcgacgtctcgtttttgatgtgcca caactcaatgaatattgcaaaatgcctctcaagcttctgacgaaccactttgagcagtgc tggaagtactactgtctgccttccggctggggcagctacggtcttgccgtggaggaagaa ctgcacctaacggagaagctcttctgggggatctttgactcgctttcccacaggaaatat gatccggatctcttccgaatgtccctcccttgtctcagtgccatagccggggccttgcca cctgattatttagataccaggatcacagccacgttggaaaaacaggtctcggtggatgct gatggcaactttgaccccaaacctatcaacactgtaaatttttccttgccagaaaaattg gaatacattgtcaccaagtatgctgagcattcacatgataaatgggcctgtgacaagagt cagagtggttggaaatatggaatttccctggatgaaaatgtgaagacccacccactaata aggcctttcaagaccttgacagagaaggagaaggaaatttatcgctggcctgcccgagag tccctgaaaaccatgctggctgtgggatggacagtagagaggactaaagagggtgaagca ttggttcaacagcgggaaaatgagaagcttcgaagtgtgtcccagaccagccagggtaat agctacaatcctgtcccccttgacctgtccaatgttgtgctctccagagaactccaggga atggtggaagttgtggctgagaactatcacaatatctgggccaagaagaagaagctggag ctagagagcaaaggtggtggcactcatcctctcttggtaccgtatgataccctgactgcc aaggaaaaattcagagaccgagaaaaggcacaggacctgttcaaattccttcaagtgaat ggtgttatagtttctagaggcataaaggacatggagctggatgccttctccatggaaaag aggttcgcctataagttcttgaagaagatcctgaaatacgtcgattctgctcaagagttt attgcccatttggaagccattgtcagtagtgggaaaacagaaaagtctccccatgaccaa gagatcaaattttttgccaaagttctcctcccactggttgaccaatacttcaccaatcac cgcctctacttcctgtcatcccctctgaagccgctcagtagcagtgggtatgcctcccat aaagagaaagaaatggtggccagcctattctgcaaacttgctgctcttgtcagacacaga atttcccttttcggtagcgattctactacaatggtgagctgtcttcacatcttagcgcag acgctggacacaaggactgtcatgaagtccggctcagagctggtgaaggctgggctacga gcattctttgaaaatgctgcggaggacttagagaagacttcagaaaacctgaagctgggc aagtttacccattccagaacgcagattaaaggcgtatctcagaatattaactacaccaca gtggctctgctccccatcctgacctccatcttcgagcacgtggctcagcatcagtttggg gtggacctgctcttgggtgatgtgcagatttcatgctaccacatactctgcagcctgtac tctcttgggacaggaaaaaacatctatgttgagaggcaacgtcctgcccttggagaatgt ctggcttctctggctgccgccataccagtggccttcctggagcctactcttaactgctac aatcctctctcagtcttcaacactaagacccccagggaaaggtctattctgggaatgcca gacacagtggaagagatgtgccctgacatcccccagctggacggcctgatgaaggaaatc aatgacctagcagagtcaggggcacgctacacagagatgccccatgtgattgaggtgatc ttgcccatgctatgcaactacctgtcctactggtgggagcggggccctgagaacctgcac acaagtacaggaccctgctgcagcaaggtcacctccgaacatctcagcctcatcctgggc aacatcttgaaaatcatcaacaacaacctgggcatcgacgaggcctcctggatgaagcgc atcgcagtgtatgcccagcccatcatcagcaaagcaaggcctgacctgctgagaagccac ttcatcccgactctggagaagctgaagaaaaaggctgtcaagacggtgcaggaggaggag cagctgaaggccgatggcaaaggggacactcaggaggctgagctcctcatcctagatgag tttgcaatcctctgcagagacctctacgccttctaccccatgctcatccgctatgtggac aataacagatccaactggctcaaaagccccgatgcggattctgaccagctatttcgaatg gtggcagaggtcttcatcttgtggtgtaaatctcacaacttcaagagggaagaacaaaat tttgtgattcagaatgaaattaataacttggcatttttaactggagatagcaaaagcaag atgtcaaaagccatgcaagtaaagtctggaggccaggaccaggagcggaagaagacaaag cggagaggagacctgtattccatccagacctccctcatcgtggctgcactcaagaaaatg ctgcccattggcttgaatatgtgcactccaggcgatcaagagctgatctccctcgctaaa tcccgatacagctatagggacacagatgaagaggtcaaggaacatctgcggaacaacttg cacttgcaggaaaagtctgatgacccagctgtaaaatggcaactaaatctctacaaggat gttctgaagactgaagaaccttccaatccagaaaagacagtggaacgtgtgcagagaatt tcagcagctgtcttccacctggaacaggtagagcagcctttgagatccaagaaggccgtc tggcacaagctgttgtcaaagcaacggaaacgggcagtggtggcctgtttcaggatggcc cctctctataacctgcccaggcaccgctctattaacctcttcctccatggctatcagaga ttttggatagaaacagaggaatattcctttgaagagaaactagtacaggatttggctaaa tctccaaaggtggaagaggaggaggaggaagagatgcaaaagcaaccagatccattgcat cagatcattctccattttagccgcaacgctctcacagagaggagcaaattggaagatgac cctttgtacacttcctactccagcatgatggctaagagttgtcaaagtggagaggatgaa gaagaggaagacaaggaaaagacatttgaagagaaagagatggaaaagcagaaaaccctc tatcagcaggctcgtctgcatgagcgtggtgctgctgagatggtccttcagatgataagc gccagcaaaggtgagatgagccccatggtggtcgagaccctgaagctggggattgccatt ctgaacggaggcaacgccggtgtacagcagaaaatgctagattatctaaaggagaaaaag gatgctggattctttcaaagtctctctggtcttatgcagtcttgcagcgtccttgatttg aatgcatttgagaggcagaataaagctgaaggcctggggatggttactgaggaaggaaca ctcattgttcgtgagcgtggtgaaaaggtgctccagaatgatgaattcacacgagatctc tttagattcctgcagctactctgtgaaggacacaacagtgactttcagaacttcttgcga actcagatgggaaacactaccaccgtcaatgtcatcatcagcactgtggactatcttctg cgtctgcaggaatcaatcagtgatttctactggtattactcagggaaagacatcattgat gaatctggacagcacaatttttccaaagctctagcggtcaccaagcagattttcaattct cttacagaatacatccagggcccttgcattgggaaccagcagagcctagctcacagtagg ctgtgggatgcagtggtcggcttcctccatgtgtttgctaacatgcagatgaaactctct caggattccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtg gtgatgcttctgtccctcctggaagggaatgtggtaaatggaactattggcaagcagatg gttgacaccctggtagaatcatctaccaatgtagaaatgatcttgaaattctttgacatg ttcttgaaacttaaggacttaaccagctcagataccttcaaagaatatgacccagacggt aaagggattatctccaaaaaagaattccagaaggccatggaagggcaaaaacagtacaca cagtcagagattgactttcttctttcatgtgcagaagccgatgaaaatgacatgtttaat tacattgattttgtagaccggttccatgagccggctaaagacatagggtttaatgtggca gtgttattgacaaatctttcggaacacatgccaaatgattctcgcctgaagtgtctgtta gatccagcagaaagtgtgctgaattacttcgagccatacctaggtcgaattgagatcatg ggtggggccaagaaaattgaacgtgtgtactttgagatcagtgaatccagtcgaactcaa tgggagaagccacaagtaaaggaatctaagcgacagttcatatttgatgttgtcaatgaa ggtggagaacaagaaaagatggaactgtttgtgaatttctgtgaggataccatctttgaa atgcagttagcatctcagatctctgagtctgactcagctgacaggctggaagaggaggag ggagatgaagagtcttcttatatgttagaaatgaatgaggaagaagaggaagagaaatct ttggaatctgcctctgcatttgccatggcctgcgtctcagtgaagagaagcatcaccaac cttctgaggaaggccaccctcaaaaacctcaggaagcaataccggaatgtgaagaagatg accatgaaggaactggtgaagatgttcttttcttttttctggatgttgttcgtggggctg ttccagttgttcttcaccatactgggaggaatcttccagatcctctggagcacagtgttc ggagggggcctggtagaaggggcgaaaaacatcagagtgactaagatcctgggtgatatg cctgatccaactcaatttggtatccatgatgatgctatggaggctgagaggacagaagta actgaggcaggcatcacacctgaacttgcacactttgccaagggtgagaagggagataca gacatcatgtcagacctctttgggctccactcaaagaaagaaggtggcttaaagcatggg cctgaagtgggcttgggtgacctctctgaaattatcagcaaggatgaaccccctacatta gagagtactgtacggaagaagaggaaagcacaggcagcagagatgaaggcagcacatgga gcagaaggaaaagcagactctgagaaggcagacctggaagatggggaaaaggaagacaaa gccaaagaggaggaacaggctgagtacttgtgggcagaagtgacaaaaaagaagaagcga cggcgtggtcagaaagttgagaaacctgaagctttcatggccaatttctttaaggggcta gaaatctatcagaccaagttactgcattacctcgccaggaatttctacaacctgaggttc cttgctctgtttgtagccttcgctatcaactttatcctgcttttttataaggtcacagaa gaacctttagaagaagagactgaagacgttgcgaacctgtggaattccttgaatgaagag gaggaggaagaagccatggtgttctttgtcctgcaggagagcactgggtacatggcgcca acactgcgggccctggccgttgtccacaccatcatctctctggtctgtgtggtgggctac tactgcctgaagttgaaagcttccttgaccatctaccaagtcaccaagtcaacttgtggc actttctccttctggttctttctgatgtatctgattaataaagatgagaccgagcacacg ggtcaggaatcctacgtctggaagatgtaccaggaaaggtgctgggatttcttcccagca ggggactgctttcgcaaacaatatgaagatcagcttggataa

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