KEGG   PATHWAY: acd03430
acd03430                    Pathway                                
Mismatch repair - Acinetobacter oleivorans
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
acd03430  Mismatch repair

Other DBs
GO: 0006298
Acinetobacter oleivorans [GN:acd]
AOLE_12955  DNA mismatch repair protein MutS [KO:K03555]
AOLE_06590  DNA mismatch repair ATPase [KO:K03572]
AOLE_17220  putative ATP-dependent DNA helicase [KO:K03657] [EC:]
AOLE_13240  xseA; exodeoxyribonuclease VII large subunit [KO:K03601] [EC:]
AOLE_13245  hypothetical protein [KO:K03602] [EC:]
AOLE_05480  Exonuclease family protein [KO:K10857] [EC:3.1.11.-]
AOLE_07430  DNA polymerase III, epsilon subunit [KO:K10857] [EC:3.1.11.-]
AOLE_00795  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AOLE_00960  ssDNA-binding protein controls activity of RecBCD nuclease [KO:K03111]
AOLE_11360  DNA polymerase III DnaE [KO:K02337] [EC:]
AOLE_00010  DNA polymerase III, beta subunit [KO:K02338] [EC:]
AOLE_06955  DNA polymerase III, tau and gamma subunits [KO:K02343] [EC:]
AOLE_16740  DNA polymerase III, delta subunit [KO:K02340] [EC:]
AOLE_10850  hypothetical protein [KO:K02341] [EC:]
AOLE_14070  bifunctional ribonuclease HI/DNA polymerase III subunit epsilon [KO:K14159] [EC:]
AOLE_18265  DNA polymerase III chi subunit, HolC family protein [KO:K02339] [EC:]
AOLE_15665  DNA ligase, NAD-dependent [KO:K01972] [EC:]
AOLE_14865  DNA adenine methylase [KO:K06223] [EC:]
AOLE_15050  site-specific DNA methylase [KO:K06223] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair]
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

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