KEGG   PATHWAY: ath04146
ath04146                    Pathway                                
Peroxisome - Arabidopsis thaliana (thale cress)
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Cellular Processes; Transport and catabolism
Pathway map
ath04146  Peroxisome

Other DBs
GO: 0005777
Arabidopsis thaliana (thale cress) [GN:ath]
AT2G45690  SSE1; shrunken seed protein (SSE1) [KO:K13335]
AT3G18160  PEX3-1; peroxin 3-1 [KO:K13336]
AT1G48635  PEX3; peroxin 3 [KO:K13336]
AT5G17550  PEX19-2; peroxin 19-2 [KO:K13337]
AT3G03490  PEX19-1; peroxin 19-1 [KO:K13337]
AT5G08470  PEX1; peroxisome 1 [KO:K13338]
AT1G03000  PEX6; peroxin 6 [KO:K13339]
AT1G29260  PEX7; peroxin 7 [KO:K13341]
AT5G56290  PEX5; peroxin 5 [KO:K13342]
AT5G62810  PEX14; peroxin 14 [KO:K13343]
AT3G07560  PEX13; peroxin 13 [KO:K13344]
AT3G04460  PEX12; peroxin-12 [KO:K13345]
AT2G26350  PEX10; peroxin 10 [KO:K13346]
AT1G79810  TED3; Pex2/Pex12 N-terminal domain-containing protein / zinc finger (C3HC4-type RING finger) family protein [KO:K06664]
AT4G04470  PMP22; Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13347]
AT4G14305  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13347]
AT2G14860  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT5G19750  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT2G42770  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT4G03410  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT3G24570  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT4G33905  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT5G43140  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT1G52870  Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein [KO:K13348]
AT2G39970  PXN; Mitochondrial substrate carrier family protein [KO:K13354]
AT5G17380  Thiamine pyrophosphate dependent pyruvate decarboxylase family protein [KO:K12261] [EC:]
AT2G01490  PAHX; phytanoyl-CoA dioxygenase (PhyH) family protein [KO:K00477] [EC:]
AT2G35690  ACX5; acyl-CoA oxidase 5 [KO:K00232] [EC:]
AT4G16760  ACX1; acyl-CoA oxidase 1 [KO:K00232] [EC:]
AT5G65110  ACX2; acyl-CoA oxidase 2 [KO:K00232] [EC:]
AT3G51840  ACX4; acyl-CoA oxidase 4 [KO:K00232] [EC:]
AT1G06290  ACX3; acyl-CoA oxidase 3 [KO:K00232] [EC:]
AT1G06310  ACX6; acyl-CoA oxidase 6 [KO:K00232] [EC:]
AT3G06690  putative acyl-coenzyme A oxidase [KO:K00232] [EC:]
AT1G04710  PKT4; peroxisomal 3-ketoacyl-CoA thiolase 4 [KO:K07513] [EC:]
AT2G33150  PKT3; peroxisomal 3-ketoacyl-CoA thiolase 3 [KO:K07513] [EC:]
AT5G48880  KAT5; peroxisomal 3-keto-acyl-CoA thiolase 2 [KO:K07513] [EC:]
AT3G12800  SDRB; short-chain dehydrogenase-reductase B [KO:K13237] [EC:]
AT2G07640  NAD(P)-binding Rossmann-fold superfamily protein [KO:K13237] [EC:]
AT5G43280  DCI1; delta(3,5),delta(2,4)-dienoyl-CoA isomerase 1 [KO:K12663] [EC:]
AT4G39850  ABCD1; peroxisomal ABC transporter 1 [KO:K25819] [EC:]
AT4G14070  AAE15; acyl-activating enzyme 15 [KO:K01897] [EC:]
AT5G27600  LACS7; long-chain acyl-CoA synthetase 7 [KO:K01897] [EC:]
AT3G05970  LACS6; long-chain acyl-CoA synthetase 6 [KO:K01897] [EC:]
AT1G64400  LACS3; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT1G49430  LACS2; long-chain acyl-CoA synthetase 2 [KO:K01897] [EC:]
AT1G77590  LACS9; long chain acyl-CoA synthetase 9 [KO:K01897] [EC:]
AT4G11030  AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT2G04350  LACS8; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT3G23790  AAE16; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT2G47240  LACS1; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT4G23850  LACS4; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:]
AT5G20070  NUDX19; nudix hydrolase homolog 19 [KO:K03426] [EC:]
AT4G04320  malonyl-CoA decarboxylase family protein [KO:K01578] [EC:]
AT4G33790  CER4; Jojoba acyl CoA reductase-related male sterility protein [KO:K13356] [EC:]
AT3G11980  MS2; Jojoba acyl CoA reductase-related male sterility protein [KO:K13356] [EC:]
AT3G44540  FAR4; fatty acid reductase 4 [KO:K13356] [EC:]
AT3G44550  FAR5; fatty acid reductase 5 [KO:K13356] [EC:]
AT3G44560  FAR8; fatty acid reductase 8 [KO:K13356] [EC:]
AT3G56700  FAR6; fatty acid reductase 6 [KO:K13356] [EC:]
AT5G22500  FAR1; fatty acid reductase 1 [KO:K13356] [EC:]
AT5G22420  FAR7; fatty acid reductase 7 [KO:K13356] [EC:]
AT5G27450  MK; mevalonate kinase [KO:K00869] [EC:]
AT2G13360  AGT; alanine:glyoxylate aminotransferase [KO:K00830] [EC:]
AT1G65930  cICDH; cytosolic NADP+-dependent isocitrate dehydrogenase [KO:K00031] [EC:]
AT1G54340  ICDH; isocitrate dehydrogenase [KO:K00031] [EC:]
AT5G14590  Isocitrate/isopropylmalate dehydrogenase family protein [KO:K00031] [EC:]
AT2G24580  FAD-dependent oxidoreductase family protein [KO:K00306] [EC:]
AT2G26800  Aldolase superfamily protein [KO:K01640] [EC:]
AT3G14415  GOX2; Aldolase-type TIM barrel family protein [KO:K11517] [EC:]
AT4G18360  GOX3; Aldolase-type TIM barrel family protein [KO:K11517] [EC:]
AT3G14150  HAOX2; Aldolase-type TIM barrel family protein [KO:K11517] [EC:]
AT3G14130  HAOX1; Aldolase-type TIM barrel family protein [KO:K11517] [EC:]
AT3G14420  GOX1; Aldolase-type TIM barrel family protein [KO:K11517] [EC:]
AT1G20630  CAT1; catalase 1 [KO:K03781] [EC:]
AT4G35090  CAT2; catalase 2 [KO:K03781] [EC:]
AT1G20620  CAT3; catalase 3 [KO:K03781] [EC:]
AT1G08830  CSD1; copper/zinc superoxide dismutase 1 [KO:K04565] [EC:]
AT2G28190  CSD2; copper/zinc superoxide dismutase 2 [KO:K04565] [EC:]
AT5G18100  CSD3; copper/zinc superoxide dismutase 3 [KO:K04565] [EC:]
AT3G56350  Iron/manganese superoxide dismutase family protein [KO:K04564] [EC:]
AT3G10920  MSD1; manganese superoxide dismutase 1 [KO:K04564] [EC:]
AT5G23310  FSD3; Fe superoxide dismutase 3 [KO:K04564] [EC:]
AT4G25100  FSD1; Fe superoxide dismutase 1 [KO:K04564] [EC:]
AT5G51100  FSD2; Fe superoxide dismutase 2 [KO:K04564] [EC:]
AT4G34890  XDH1; xanthine dehydrogenase 1 [KO:K00106] [EC:]
AT4G34900  XDH2; xanthine dehydrogenase 2 [KO:K00106] [EC:]
AT4G05530  IBR1; indole-3-butyric acid response 1 [KO:K11147] [EC:1.1.-.-]
Wanders RJ, Waterham HR
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
Biochim Biophys Acta 1763:1707-20 (2006)
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
Peroxisome biogenesis disorders.
Biochim Biophys Acta 1763:1733-48 (2006)
Rottensteiner H, Theodoulou FL
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
Biochim Biophys Acta 1763:1527-40 (2006)
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
Biochem Biophys Res Commun 344:948-54 (2006)
ath00071  Fatty acid degradation
ath00230  Purine metabolism
ath00564  Glycerophospholipid metabolism
ath00565  Ether lipid metabolism
ath00900  Terpenoid backbone biosynthesis
KO pathway

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