KEGG   PATHWAY: cjc00982
Entry
cjc00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Callithrix jacchus (white-tufted-ear marmoset)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
cjc00982  Drug metabolism - cytochrome P450
cjc00982

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385343  CYP2D19; cytochrome P450 2D19 [KO:K17712] [EC:1.14.14.1]
100415600  cytochrome P450 2D6 [KO:K17712] [EC:1.14.14.1]
100404344  CYP3A4; cytochrome P450 3A21 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
100408861  FMO4; dimethylaniline monooxygenase [N-oxide-forming] 4 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100409221  FMO1; flavin-containing monooxygenase 1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100409812  FMO2; flavin-containing monooxygenase 2 isoform X1 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100410172  FMO3; flavin-containing monooxygenase 3 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100406306  FMO5; flavin-containing monooxygenase 5 [KO:K00485] [EC:1.14.13.8 1.8.1.-]
100389947  CYP2C19; cytochrome P450 2C19 [KO:K17721] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
100405958  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
100404952  CYP3A5; cytochrome P450 3A5 [KO:K17690] [EC:1.14.14.1]
100405792  CYP3A90; cytochrome P450, family 3, subfamily A, polypeptide [KO:K17690] [EC:1.14.14.1]
100391062  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100387311  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100389598  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100400212  GSTO2; glutathione S-transferase omega-2 isoform X3 [KO:K00799] [EC:2.5.1.18]
100399847  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100386143  MGST3; microsomal glutathione S-transferase 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
100386984  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100400731  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100401098  glutathione S-transferase alpha-4-like isoform X4 [KO:K00799] [EC:2.5.1.18]
100401476  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100392584  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100406483  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
100385358  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
100407094  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100407453  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100388510  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100393909  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
100411587  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
100895885  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
118146251  glutathione S-transferase theta-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128928073  glutathione S-transferase theta-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
100398632  GSTP1; glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
100403214  GSTK1; glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
100399167  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100389979  ADH7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1 [KO:K13951] [EC:1.1.1.1]
100410778  ADH1B; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
100391782  ADH1A; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
100411741  alcohol dehydrogenase 1C-like isoform X1 [KO:K13951] [EC:1.1.1.1]
100390830  ADH1C; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
100394688  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
100395052  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100411335  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100405175  aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
100385438  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
118142865  aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
118145542  aldehyde dehydrogenase family 3 member B1 isoform X2 [KO:K00129] [EC:1.2.1.5]
100403544  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
100407187  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100394388  AOX2; aldehyde oxidase 2 isoform X2 [KO:K00157] [EC:1.2.3.1]
100393665  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100388812  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
100405984  UDP-glucuronosyltransferase 1A3 isoform X2 [KO:K00699] [EC:2.4.1.17]
100409222  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
103792017  UDP-glucuronosyltransferase 2B4 isoform X1 [KO:K00699] [EC:2.4.1.17]
100412562  UDP-glucuronosyltransferase 2B7 isoform X1 [KO:K00699] [EC:2.4.1.17]
100414245  UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
100391186  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
100413404  UDP-glucuronosyltransferase 2B4 isoform X1 [KO:K00699] [EC:2.4.1.17]
100392712  CYP1A2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100397922  CYP2E1; cytochrome P450 2E1 precursor [KO:K07415] [EC:1.14.14.-]
100402764  cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
100390915  CYP2C8; cytochrome P450 2C8 precursor [KO:K17718] [EC:1.14.14.1]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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