KEGG   PATHWAY: dme04341
Entry
dme04341                    Pathway                                

Name
Hedgehog signaling pathway - fly - Drosophila melanogaster (fruit fly)
Description
Hedgehog (Hh) signaling plays essential roles in embryonic development and adult tissue homeostasis. It is first elucidated by genetic studies in Drosophila and the core of the Hh signaling pathway is conserved in evolution. The Hh signaling components include an important complex composed of Cos2, Fu, SuFu and Ci. In the absence of Hh, Ptc inhibits Smo and the complex promotes the formation of the Ci's repressor form CiR. In the presentation of Hh, binding Hh to Ptc relieves Smo repression, which results in Ci's activation and then the increased transcription of Hh target genes in the nucleus.
Class
Environmental Information Processing; Signal transduction
Pathway map
dme04341  Hedgehog signaling pathway - fly
dme04341

Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG2411  ptc; patched [KO:K06225]
Dmel_CG11561  smo; smoothened [KO:K06226]
Dmel_CG1708  cos; costa, isoform B [KO:K06227]
Dmel_CG6551  fu; fused [KO:K06228] [EC:2.7.11.1]
Dmel_CG4379  Pka-C1; protein kinase, cAMP-dependent, catalytic subunit 1, isoform D [KO:K04345] [EC:2.7.11.11]
Dmel_CG12066  Pka-C2; protein kinase, cAMP-dependent, catalytic subunit 2, isoform B [KO:K04345] [EC:2.7.11.11]
Dmel_CG2028  CkIalpha; casein kinase ialpha, isoform D [KO:K08957] [EC:2.7.11.1]
Dmel_CG12147  CG12147; uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dmel_CG2577  CG2577; uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dmel_CG7094  CG7094; uncharacterized protein [KO:K08957] [EC:2.7.11.1]
Dmel_CG6963  gish; gilgamesh, isoform H [KO:K08958] [EC:2.7.11.1]
Dmel_CG2048  dco; discs overgrown, isoform D [KO:K08960] [EC:2.7.11.1]
Dmel_CG2621  sgg; shaggy, isoform B [KO:K03083] [EC:2.7.11.26]
Dmel_CG31003  gskt; gasket [KO:K03083] [EC:2.7.11.26]
Dmel_CG2125  ci; cubitus interruptus, isoform A [KO:K16799]
Dmel_CG6054  Su(fu); suppressor of fused [KO:K06229]
Dmel_CG3412  slmb; supernumerary limbs, isoform C [KO:K03362]
Dmel_CG1877  Cul1; cullin 1, isoform D [KO:K03347]
Dmel_CG11261  Cul6; cullin 6 [KO:K03347]
Dmel_CG16983  SkpA; SKP1-related A, isoform H [KO:K03094]
Dmel_CG12227  SkpF; SKP1-related F [KO:K03094]
Dmel_CG8881  SkpB; SKP1-related B [KO:K03094]
Dmel_CG11942  SkpE; SKP1-related E [KO:K03094]
Dmel_CG11941  SkpC; SKP1-related C [KO:K03094]
Dmel_CG12700  SkpD; SKP1-related D [KO:K03094]
Dmel_CG15800  CG15800; uncharacterized protein [KO:K03094]
Dmel_CG43089  CG43089; uncharacterized protein, isoform B [KO:K03094]
Dmel_CG16982  Roc1a; regulator of cullins 1a, isoform D [KO:K03868] [EC:2.3.2.32]
Dmel_CG16988  Roc1b; regulator of cullins 1b [KO:K03868] [EC:2.3.2.32]
Dmel_CG12537  rdx; roadkill, isoform E [KO:K10523]
Dmel_CG9885  dpp; decapentaplegic, isoform A [KO:K04662]
Dmel_CG9015  en; engrailed, isoform A [KO:K09319]
Dmel_CG4637  hh; hedgehog [KO:K06224]
Dmel_CG11495  rasp; rasp [KO:K24678] [EC:2.3.1.-]
Dmel_CG2019  disp; dispatched [KO:K24680]
Dmel_CG9211  ihog; interference hedgehog [KO:K20244]
Dmel_CG32796  boi; brother of ihog, isoform G [KO:K20245]
Dmel_CG4943  Smurf; SMAD specific E3 ubiquitin protein ligase, isoform B [KO:K04678] [EC:2.3.2.26]
Dmel_CG17998  Gprk2; G protein-coupled receptor kinase 2, isoform B [KO:K08291] [EC:2.7.11.16]
Dmel_CG42616  Cul3; cullin 3, isoform C [KO:K03869]
Reference
  Authors
Wilson CW, Chuang PT
  Title
Mechanism and evolution of cytosolic Hedgehog signal transduction.
  Journal
Development 137:2079-94 (2010)
DOI:10.1242/dev.045021
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Aikin RA, Ayers KL, Therond PP
  Title
The role of kinases in the Hedgehog signalling pathway.
  Journal
EMBO Rep 9:330-6 (2008)
DOI:10.1038/embor.2008.38
Reference
  Authors
Ingham PW, Nakano Y, Seger C
  Title
Mechanisms and functions of Hedgehog signalling across the metazoa.
  Journal
Nat Rev Genet 12:393-406 (2011)
DOI:10.1038/nrg2984
Reference
  Authors
Jiang J
  Title
Regulation of Hh/Gli signaling by dual ubiquitin pathways.
  Journal
Cell Cycle 5:2457-63 (2006)
DOI:10.4161/cc.5.21.3406
Reference
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
  Authors
Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J
  Title
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
  Journal
Dev Cell 10:719-29 (2006)
DOI:10.1016/j.devcel.2006.05.004
Reference
  Authors
Zhou Z, Xu C, Chen P, Liu C, Pang S, Yao X, Zhang Q
  Title
Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.
  Journal
Sci Rep 5:12709 (2015)
DOI:10.1038/srep12709
Related
pathway
dme04120  Ubiquitin mediated proteolysis
KO pathway
ko04341   
LinkDB

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