KEGG   PATHWAY: fca04145
Entry
fca04145                    Pathway                                
Name
Phagosome - Felis catus (domestic cat)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
fca04145  Phagosome
fca04145

Other DBs
GO: 0045335
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101095593  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
101084298  STX12; syntaxin-12 [KO:K13813]
101095016  STX7; syntaxin-7 isoform X1 [KO:K08488]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101081104  CORO1A; coronin-1A [KO:K13882]
101088331  STX18; syntaxin-18 [KO:K08492]
101089536  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
101095479  FLAI-K; saoe class I histocompatibility antigen, A alpha chain-like precursor [KO:K06751]
105260551  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
101081297  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
101080790  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111556177  HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X1 [KO:K06751]
101099296  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
101094232  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101080285  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101099995  RAB5A; ras-related protein Rab-5A [KO:K07887]
101093783  RAB5B; ras-related protein Rab-5B [KO:K07888]
101094966  RAB5C; ras-related protein Rab-5C [KO:K07889]
101088764  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
101099249  PIK3C3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
493880  TFRC; transferrin receptor protein 1 [KO:K06503]
101088702  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101091723  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101098295  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101092601  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101084001  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101086301  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
101091205  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
101101208  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101081815  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101081968  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101084539  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
101093576  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101098998  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101091676  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101093093  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101084995  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
101096367  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X7 [KO:K02154]
101089593  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101083709  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101095399  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101100610  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101095225  ATP6V1H; LOW QUALITY PROTEIN: V-type proton ATPase subunit H [KO:K02144]
101101434  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101084376  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
101091770  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101085959  RAB7A; ras-related protein Rab-7a [KO:K07897]
101088049  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
101085081  RILP; rab-interacting lysosomal protein [KO:K13883]
101082576  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101082005  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
101092506  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X4 [KO:K10415]
101089708  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X4 [KO:K10415]
101095299  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101093542  DYNC1LI1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
101098780  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101095277  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101096402  tubulin alpha-1B chain [KO:K07374]
101099268  tubulin alpha-8 chain isoform X1 [KO:K07374]
101081992  tubulin alpha-1C chain [KO:K07374]
101090556  tubulin alpha-3 chain [KO:K07374]
101096902  tubulin alpha-1A chain [KO:K07374]
101080975  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100188929  TUBB1; tubulin beta-1 chain [KO:K07375]
101084876  TUBB2B; tubulin beta-2B chain [KO:K07375]
101095657  TUBB; tubulin beta chain [KO:K07375]
101096420  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
101084324  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
101086953  TUBB4A; tubulin beta-4A chain [KO:K07375]
109499596  TUBB2A; tubulin beta-2A chain [KO:K07375]
100125859  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
100169945  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
101094121  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101098389  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101100342  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100142673  MPO; myeloperoxidase precursor [KO:K10789] [EC:1.11.2.2]
101087880  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101086605  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105259631  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101082891  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101101202  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101080443  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
751112  PDP; cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
101082639  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111559122  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111559123  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101083283  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101089426  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
101086402  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
101084323  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
101084431  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
101083591  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
111560442  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
101089770  LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
111556311  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
101087384  CALR; calreticulin [KO:K08057]
101085686  CANX; calnexin [KO:K08054]
105261212  FCAR; immunoglobulin alpha Fc receptor [KO:K06513]
101087936  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101087550  FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
493677  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463]
101088940  LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
111561323  C1R; LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
101087957  integrin alpha-M isoform X4 [KO:K06461]
101087258  ITGB2; integrin beta-2 [KO:K06464]
101088468  complement C3-like [KO:K03990]
101091014  COLEC11; collectin-11 isoform X6 [KO:K10066]
101094054  COLEC12; collectin-12 [KO:K10062]
101100840  MBL2; mannose-binding protein C [KO:K03991]
101101085  pulmonary surfactant-associated protein A-like isoform X1 [KO:K10067]
101100595  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
101085820  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
101090237  ITGA2; integrin alpha-2 [KO:K06481]
101093870  ITGA5; integrin alpha-5 [KO:K06484]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
101092159  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
101101247  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101087199  THBS4; thrombospondin-4 [KO:K04659]
101088820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101100567  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
101093580  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493662  TLR6; toll-like receptor 6 [KO:K10169]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101096335  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
101092193  MRC1; macrophage mannose receptor 1 [KO:K06560]
101082106  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
100462978  CD209; CD209 antigen [KO:K06563]
101083523  CLEC7A; C-type lectin domain family 7 member A isoform X3 [KO:K10074]
101081290  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
101083611  MARCO; macrophage receptor MARCO [KO:K13884]
101086238  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
101083715  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
101093842  CD36; platelet glycoprotein 4 [KO:K06259]
101091745  cytochrome b-245 light chain [KO:K08009]
101086207  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101098840  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101088712  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101095507  NCF4; LOW QUALITY PROTEIN: neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
fca04142  Lysosome
fca04144  Endocytosis
fca04610  Complement and coagulation cascades
fca04612  Antigen processing and presentation
fca04620  Toll-like receptor signaling pathway
fca04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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