KEGG   PATHWAY: fca04520
Entry
fca04520                    Pathway                                
Name
Adherens junction - Felis catus (domestic cat)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fca04520  Adherens junction
fca04520

Other DBs
GO: 0005912
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101098252  NECTIN1; nectin-1 isoform X2 [KO:K06081]
101087027  NECTIN2; nectin-2 isoform X1 [KO:K06531]
101094872  NECTIN3; nectin-3 isoform X1 [KO:K06592]
101092485  NECTIN4; nectin-4 isoform X1 [KO:K06593]
101100223  PARD3; partitioning defective 3 homolog isoform X8 [KO:K04237]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101096829  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101095243  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101095721  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101087841  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101087366  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
101083083  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X2 [KO:K05753]
101082837  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101086527  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
101081386  AFDN; afadin isoform X1 [KO:K05702]
101083391  LMO7; LIM domain only protein 7 isoform X17 [KO:K06084]
101097747  SSX2IP; afadin- and alpha-actinin-binding protein isoform X1 [KO:K06085]
101090050  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X16 [KO:K06086]
101093978  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101097986  ACTN1; alpha-actinin-1 isoform X6 [KO:K05699]
101089215  VCL; vinculin isoform X2 [KO:K05700]
101082238  TJP1; tight junction protein ZO-1 isoform X6 [KO:K05701]
101095391  CDH1; cadherin-1 [KO:K05689]
101091972  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101089324  CTNNA1; catenin alpha-1 [KO:K05691]
101088568  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
101086346  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101092352  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101080832  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X8 [KO:K05693] [EC:3.1.3.48]
101100899  PTPRB; receptor-type tyrosine-protein phosphatase beta isoform X1 [KO:K05694] [EC:3.1.3.48]
101081238  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
101099626  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
101087073  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
101086598  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
101084186  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101093065  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101087664  CSNK2B; casein kinase II subunit beta [KO:K03115]
101098768  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101089850  TCF7L1; transcription factor 7-like 1 isoform X3 [KO:K04490]
101095618  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101088077  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101094235  FER; tyrosine-protein kinase Fer isoform X1 [KO:K08889] [EC:2.7.10.2]
101085720  FYN; LOW QUALITY PROTEIN: tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
101090724  YES1; tyrosine-protein kinase Yes [KO:K05705] [EC:2.7.10.2]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101090987  SNAI2; zinc finger protein SNAI2 isoform X1 [KO:K05706]
101100799  SNAI1; zinc finger protein SNAI1 [KO:K05707]
101094057  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
101091725  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101101387  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101093650  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101088344  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101094471  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101080751  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101084501  CDH5; cadherin-5 isoform X2 [KO:K06533]
101080319  HEG1; protein HEG homolog 1 isoform X1 [KO:K24472]
101083757  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
101100375  CCM2; cerebral cavernous malformations 2 protein isoform X2 [KO:K26416]
101090640  PDCD10; programmed cell death protein 10 [KO:K18269]
101085162  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
101095216  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X5 [KO:K04678] [EC:2.3.2.26]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101086214  RASIP1; ras-interacting protein 1 [KO:K26417]
101094810  RADIL; LOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein [KO:K26418]
101099818  ARHGAP29; rho GTPase-activating protein 29 isoform X2 [KO:K20644]
101092552  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101101169  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
493974  MYL5; myosin light chain 5 [KO:K12753]
101095326  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
101097882  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101082365  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
101085247  myosin regulatory light chain 12B [KO:K12757]
101085837  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
101094812  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
Reference
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
fca04010  MAPK signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04310  Wnt signaling pathway
fca04350  TGF-beta signaling pathway
fca04530  Tight junction
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
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