KEGG   PATHWAY: fca04721
Entry
fca04721                    Pathway                                
Name
Synaptic vesicle cycle - Felis catus (domestic cat)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
fca04721  Synaptic vesicle cycle
fca04721

Other DBs
GO: 0016079 0048488
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101096880  SLC32A1; vesicular inhibitory amino acid transporter isoform X1 [KO:K15015]
101094843  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
101086507  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
101096265  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
101096579  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
101098576  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
100216332  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
654422  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
101101516  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
101085865  RAB3A; ras-related protein Rab-3A [KO:K07882]
101088410  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
101097118  STX1A; syntaxin-1A isoform X1 [KO:K04560]
101099148  STX3; syntaxin-3 isoform X1 [KO:K08486]
101083133  STX1B; syntaxin-1B [KO:K08486]
101080921  STX2; syntaxin-2 isoform X7 [KO:K08486]
101092061  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
101089655  UNC13B; protein unc-13 homolog B isoform X11 [KO:K15293]
101087486  UNC13C; protein unc-13 homolog C [KO:K15293]
101091602  UNC13A; protein unc-13 homolog A isoform X10 [KO:K15293]
101092511  SNAP25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
101084167  CPLX2; complexin-2 [KO:K15294]
101094265  CPLX1; complexin-1 isoform X1 [KO:K15294]
101083085  CPLX3; complexin-3 [KO:K15295]
101080580  CPLX4; complexin-4 isoform X1 [KO:K15295]
101094827  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101088797  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
101088535  NAPA; alpha-soluble NSF attachment protein isoform X1 [KO:K15296]
654421  DNM1; dynamin-1 isoform X2 [KO:K01528] [EC:3.6.5.5]
101090983  DNM3; dynamin-3 isoform X5 [KO:K01528] [EC:3.6.5.5]
101100788  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
101097521  CLTA; clathrin light chain A isoform X4 [KO:K04644]
101088646  CLTB; clathrin light chain B isoform X2 [KO:K04645]
101081257  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101081341  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
101097097  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101101430  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101084752  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101088686  AP2M1; AP-2 complex subunit mu isoform X2 [KO:K11826]
101090159  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101091723  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101098295  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101092601  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101084001  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101086301  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X8 [KO:K02148]
101091205  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
101101208  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X2 [KO:K02150]
101081815  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101081968  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101084539  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
101093576  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101098998  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101091676  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101093093  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101084995  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
101096367  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X7 [KO:K02154]
101089593  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101083709  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101095399  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101100610  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101095225  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101101434  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101084376  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
101088066  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
101099605  SLC6A2; arylamine N-acetyltransferase 1 isoform X3 [KO:K05035]
101101618  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101091163  SLC6A4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
101085226  SLC6A9; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 1 [KO:K05038]
101085314  SLC6A5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
101086454  SLC6A7; sodium-dependent proline transporter isoform X2 [KO:K05040]
101092834  SLC6A11; sodium- and chloride-dependent GABA transporter 3 isoform X1 [KO:K05044]
101088338  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
101088087  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046]
101099844  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
493929  SLC1A2; excitatory amino acid transporter 2 [KO:K05613]
101098606  SLC1A3; excitatory amino acid transporter 1 [KO:K05614]
101098776  SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
101093035  SLC1A7; excitatory amino acid transporter 5 isoform X2 [KO:K05618]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
fca04144  Endocytosis
fca04724  Glutamatergic synapse
fca04725  Cholinergic synapse
fca04726  Serotonergic synapse
fca04727  GABAergic synapse
fca04728  Dopaminergic synapse
KO pathway
ko04721   
LinkDB

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