KEGG   PATHWAY: fca05152
Entry
fca05152                    Pathway                                
Name
Tuberculosis - Felis catus (domestic cat)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
fca05152  Tuberculosis
fca05152

Organism
Felis catus (domestic cat) [GN:fca]
Gene
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101097773  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
100142684  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101085995  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100502578  BID; BH3-interacting domain death agonist [KO:K04726]
493837  BAX; apoptosis regulator BAX [KO:K02159]
101098213  cytochrome c [KO:K08738]
101094614  cytochrome c, testis-specific-like [KO:K08738]
101088122  cytochrome c-like [KO:K08738]
101100947  cytochrome c [KO:K08738]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768257  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101098221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5 [KO:K04515] [EC:2.7.11.17]
101098090  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X16 [KO:K04515] [EC:2.7.11.17]
101084342  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101098615  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
493965  IFNG; interferon gamma precursor [KO:K04687]
101086811  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101092286  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
101084377  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
101084561  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101087372  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
101099317  RFX5; LOW QUALITY PROTEIN: DNA-binding protein RFX5 [KO:K08061]
101098525  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
101088294  RFXAP; regulatory factor X-associated protein [KO:K08063]
101098871  NFYA; nuclear transcription factor Y subunit alpha isoform X6 [KO:K08064]
101083016  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
101099313  NFYC; nuclear transcription factor Y subunit gamma isoform X3 [KO:K08066]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101085953  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
101088344  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101094471  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
493683  IL10; interleukin-10 precursor [KO:K05443]
101087601  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
101090038  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
101083283  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101094859  CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
101089236  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101083523  CLEC7A; C-type lectin domain family 7 member A isoform X3 [KO:K10074]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101087013  SYK; tyrosine-protein kinase SYK isoform X3 [KO:K05855] [EC:2.7.10.2]
101093152  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
101088885  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
101099570  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
101096863  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
101086783  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
101089072  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
101088683  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077]
101097963  lipopolysaccharide-binding protein [KO:K05399]
109498011  lipopolysaccharide-binding protein-like [KO:K05399]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493660  TLR1; toll-like receptor 1 [KO:K05398]
493662  TLR6; toll-like receptor 6 [KO:K10169]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101088688  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101086888  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101096604  RELA; transcription factor p65 [KO:K04735]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101087020  NOS2; nitric oxide synthase, inducible isoform X2 [KO:K13241] [EC:1.14.13.39]
493687  IL6; interleukin-6 precursor [KO:K05405]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
493688  IL18; interleukin-18 precursor [KO:K05482]
654423  IL23A; interleukin-23 subunit alpha [KO:K05426]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
768274  IL1B; interleukin-1 beta precursor [KO:K04519]
100144613  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
101090819  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
493839  TLR9; toll-like receptor 9 precursor [KO:K10161]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
101088440  interferon alpha-2-like [KO:K05414]
101081371  interferon alpha-like [KO:K05414]
493840  IFNA5; LOW QUALITY PROTEIN: interferon alpha-5 [KO:K05414]
111557596  interferon alpha-like [KO:K05414]
493849  IFNB1; interferon beta precursor [KO:K05415]
100462978  CD209; CD209 antigen [KO:K06563]
101085657  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101094133  LSP1; lymphocyte-specific protein 1 isoform X5 [KO:K14957]
101088599  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
101092156  KSR1; kinase suppressor of Ras 1 isoform X9 [KO:K14958]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
768263  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
101093414  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101098469  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
100750221  CYP27B1; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X2 [KO:K07438] [EC:1.14.15.18]
100316614  VDR; vitamin D3 receptor isoform X2 [KO:K08539]
100533978  CAMP; cathelicidin antimicrobial peptide precursor [KO:K13916]
101088468  complement C3-like [KO:K03990]
102899461  CR1L; complement component receptor 1-like protein [KO:K04011]
101087698  ITGAX; LOW QUALITY PROTEIN: integrin alpha-X [KO:K06462]
101087258  ITGB2; integrin beta-2 [KO:K06464]
101087957  integrin alpha-M isoform X4 [KO:K06461]
101096335  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
101092193  MRC1; macrophage mannose receptor 1 [KO:K06560]
101082106  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
101081345  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101084918  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
101081534  CALM2; calmodulin-2 [KO:K02183]
101099307  calmodulin-like protein 3 [KO:K02183]
102902667  calmodulin-like [KO:K02183]
101091063  CALM3; calmodulin-3 isoform X1 [KO:K02183]
101097703  calmodulin-alpha-like [KO:K02183]
101094679  CALM1; calmodulin-1 [KO:K02183]
111556187  calmodulin-like protein 4 [KO:K02183]
101086824  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101100214  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101099249  PIK3C3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101099995  RAB5A; ras-related protein Rab-5A [KO:K07887]
101093783  RAB5B; ras-related protein Rab-5B [KO:K07888]
101094966  RAB5C; ras-related protein Rab-5C [KO:K07889]
101088764  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
101085959  RAB7A; ras-related protein Rab-7a [KO:K07897]
101094625  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101084995  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
101096367  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X7 [KO:K02154]
101089593  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101083709  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101095399  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101100610  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101095225  ATP6V1H; LOW QUALITY PROTEIN: V-type proton ATPase subunit H [KO:K02144]
101091770  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101101434  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101084376  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
100125859  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
100169945  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
101081104  CORO1A; coronin-1A [KO:K13882]
101087936  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101087550  FCGR2B; Fc fragment of IgG, low affinity IIb, receptor (CD32) [KO:K12560]
493677  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
fca04010  MAPK signaling pathway
fca04210  Apoptosis
fca04612  Antigen processing and presentation
fca04620  Toll-like receptor signaling pathway
fca04621  NOD-like receptor signaling pathway
fca04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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