KEGG   PATHWAY: fca05205
Entry
fca05205                    Pathway                                
Name
Proteoglycans in cancer - Felis catus (domestic cat)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
fca05205  Proteoglycans in cancer
fca05205

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101098744  CD44; CD44 antigen isoform X9 [KO:K06256]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101084469  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
101088615  CTTN; LOW QUALITY PROTEIN: src substrate cortactin [KO:K06106]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101097212  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
101087417  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101086264  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
101096187  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
101094623  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101092784  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X4 [KO:K04365] [EC:2.7.11.1]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101089839  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101087841  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101095156  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
552888  ESR1; estrogen receptor [KO:K08550]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101098612  FLNB; filamin-B isoform X4 [KO:K04437]
101081210  FLNC; LOW QUALITY PROTEIN: filamin-C [KO:K04437]
101082637  FLNA; filamin-A isoform X1 [KO:K04437]
101087171  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101094530  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101083892  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101092552  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101100129  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K10380]
101096228  ANK1; LOW QUALITY PROTEIN: ankyrin-1 [KO:K10380]
101097842  ANK3; ankyrin-3 isoform X15 [KO:K10380]
101088326  GAB1; GRB2-associated-binding protein 1 isoform X4 [KO:K09593]
101094274  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101088766  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101100922  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101092932  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109492306  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101089624  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
101098766  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X5 [KO:K12329]
101092809  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101085657  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101088695  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X3 [KO:K04958]
101101230  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101087993  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101098221  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5 [KO:K04515] [EC:2.7.11.17]
101098090  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X16 [KO:K04515] [EC:2.7.11.17]
101084342  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101098615  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100174790  NANOG; homeobox protein NANOG [KO:K10164]
101084379  LOW QUALITY PROTEIN: homeobox protein NANOG-like [KO:K10164]
101099414  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:3.6.4.13]
101100622  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101094007  TWIST1; twist-related protein 1 [KO:K09069]
109502970  TWIST2; twist-related protein 2 [KO:K09069]
101097909  HOXD10; homeobox protein Hox-D10 [KO:K09295]
101101236  DCN; decorin [KO:K04660]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
101091812  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X3 [KO:K04688] [EC:2.7.11.1]
101092561  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101081817  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
101098495  RPS6; 40S ribosomal protein S6 [KO:K02991]
101089756  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
493668  CAV1; caveolin-1 [KO:K06278]
493667  CAV2; caveolin-2 [KO:K12958]
101081453  CAV3; caveolin-3 [KO:K12959]
493846  CD63; CD63 antigen [KO:K06497]
493943  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
768263  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
101093647  PDCD4; programmed cell death protein 4 [KO:K16865]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
101085388  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
101100073  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
101097342  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101083686  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
101095461  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
101096508  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101091215  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101098838  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101084185  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101100982  LUM; lumican [KO:K08122]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493939  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
101093414  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101087179  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101090101  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
101083879  HPSE2; inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
101101459  SDC1; syndecan-1 [KO:K06257]
101098338  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
101091240  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
101092216  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101089428  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105261147  collagen alpha-1(I) chain [KO:K06236]
101090237  ITGA2; integrin alpha-2 [KO:K06481]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
101100765  VTN; vitronectin [KO:K06251]
101085820  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
101092159  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
101081746  FN1; fibronectin isoform X1 [KO:K05717]
101101247  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
101094190  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101082735  FZD1; frizzled-1 [KO:K02432]
101087255  FZD7; frizzled-7 [KO:K02432]
101085253  FZD2; frizzled-2 [KO:K02235]
101095250  FZD3; frizzled-3 isoform X1 [KO:K02329]
101093710  FZD4; frizzled-4 isoform X1 [KO:K02354]
101101229  FZD8; frizzled-8 [KO:K02375]
101097508  FZD5; frizzled-5 [KO:K02375]
101101443  FZD6; frizzled-6 [KO:K02376]
101087697  FZD9; frizzled-9 [KO:K02842]
101081169  FZD10; frizzled-10 [KO:K02842]
101093870  ITGA5; integrin alpha-5 [KO:K06484]
101092416  SDC2; syndecan-2 [KO:K16336]
101092519  EZR; ezrin isoform X1 [KO:K08007]
101090715  RDX; radixin isoform X2 [KO:K05762]
101080871  MSN; moesin [KO:K05763]
101090430  SDC4; syndecan-4 [KO:K16338]
100135772  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
101099133  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
101085500  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101088847  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
101092925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101080675  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101082196  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101093069  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
101080922  PXN; paxillin isoform X2 [KO:K05760]
101095952  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101093578  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
101094122  GPC1; glypican-1 isoform X1 [KO:K08107]
101093644  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
101094739  GPC3; glypican-3 isoform X1 [KO:K08109]
493672  WNT2; protein Wnt-2 precursor [KO:K00182]
101080904  WNT2B; protein Wnt-2b [KO:K00182]
101088533  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101080607  WNT3A; protein Wnt-3a [KO:K00312]
101095185  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
101085809  WNT5B; protein Wnt-5b [KO:K00444]
101080694  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101099392  WNT6; protein Wnt-6 [KO:K00445]
101083664  WNT7A; protein Wnt-7a [KO:K00572]
101095592  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101089489  WNT8A; protein Wnt-8a [KO:K00714]
101096357  WNT8B; protein Wnt-8b [KO:K00714]
101080844  WNT9B; LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
111560436  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
101092455  WNT10A; protein Wnt-10a [KO:K01357]
101093948  WNT10B; protein Wnt-10b [KO:K01357]
101100080  WNT11; protein Wnt-11 [KO:K01384]
101090252  WNT16; protein Wnt-16 [KO:K01558]
111557492  SHH; sonic hedgehog protein [KO:K11988]
101100146  IHH; indian hedgehog protein [KO:K11989]
101085077  PTCH1; protein patched homolog 1 isoform X4 [KO:K06225]
101087567  SMO; smoothened homolog [KO:K06226]
101094520  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101087880  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101086605  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105259631  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101082891  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101101202  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101080443  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
751112  PDP; cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
101082639  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111559122  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111559123  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101093207  HSPB2; heat shock protein beta-2 [KO:K09543]
101087073  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
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Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
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Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
fca04010  MAPK signaling pathway
fca04020  Calcium signaling pathway
fca04066  HIF-1 signaling pathway
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04210  Apoptosis
fca04310  Wnt signaling pathway
fca04340  Hedgehog signaling pathway
fca04350  TGF-beta signaling pathway
fca04370  VEGF signaling pathway
fca04510  Focal adhesion
fca04520  Adherens junction
fca04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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