Entry Name Allograft rejection - Felis catus (domestic cat)
Description Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Felis catus (domestic cat) [GN:
fca ]
Gene 101095479 FLAI-K; saoe class I histocompatibility antigen, A alpha chain-like precursor [KO:K06751 ]
105260551 LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751 ]
101081297 LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
101080790 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
111556177 HLA class I histocompatibility antigen, B-45 alpha chain-like isoform X1 [KO:K06751 ]
101099296 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
101094232 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
101080285 HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751 ]
493786 CD80; T-lymphocyte activation antigen CD80 [KO:K05412 ]
493704 CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413 ]
493802 CD28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470 ]
493741 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
768273 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
493945 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
493881 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
101088996 DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752 ]
101098301 DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752 ]
111556169 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101082906 HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752 ]
101084108 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
101088734 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
111556173 HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752 ]
101090518 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
111560441 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
101090771 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
111560440 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101082653 DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752 ]
101090265 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
101084962 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
111560443 HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752 ]
111560444 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
111560445 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
111556176 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
111558969 LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
111558970 HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
102899262 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
101085363 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
Compound Reference Authors Arakelov A, Lakkis FG.
Title The alloimmune response and effector mechanisms of allograft rejection.
Journal Semin Nephrol 20:95-102 (2000)
Reference Authors Le Moine A, Goldman M, Abramowicz D.
Title Multiple pathways to allograft rejection.
Journal Reference Authors Trivedi HL.
Title Immunobiology of rejection and adaptation.
Journal Reference Authors Pietra BA.
Title Transplantation immunology 2003: simplified approach.
Journal Reference Authors Oka T, Yoshimura N.
Title Immunosuppression in organ transplantation.
Journal Reference Authors Sayegh MH.
Title Why do we reject a graft? Role of indirect allorecognition in graft rejection.
Journal Reference Authors Benichou G.
Title Direct and indirect antigen recognition: the pathways to allograft immune rejection.
Journal Reference Authors Turvey SE, Wood KJ.
Title Immunobiology of solid organ transplantation.
Journal Int Surg 84:279-90 (1999)
Reference Authors Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title Immunobiology 6th edition
Journal Garland Science Publishing (2005)
Reference Authors Game DS, Lechler RI.
Title Pathways of allorecognition: implications for transplantation tolerance.
Journal Reference Authors Lechler RI, Garden OA, Turka LA.
Title The complementary roles of deletion and regulation in transplantation tolerance.
Journal Related fca04610 Complement and coagulation cascades
fca04612 Antigen processing and presentation
fca04660 T cell receptor signaling pathway
fca04662 B cell receptor signaling pathway
KO pathway LinkDB All DBs
