KEGG   PATHWAY: hsa00730
Entry
hsa00730                    Pathway                                
Name
Thiamine metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00730  Thiamine metabolism
hsa00730

Drug
D10595  Asfotase alfa (USAN/INN)
D12277  Ilofotase alfa (USAN/INN)
D12991  Efzimfotase alfa (USAN/INN)
Other DBs
GO: 0006772
Organism
Homo sapiens (human) [GN:hsa]
Gene
9054  NFS1; NFS1 cysteine desulfurase [KO:K04487] [EC:2.8.1.7]
84284  NTPCR; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
248  ALPI; alkaline phosphatase, intestinal [KO:K01077] [EC:3.1.3.1]
249  ALPL; alkaline phosphatase, biomineralization associated [KO:K01077] [EC:3.1.3.1]
250  ALPP; alkaline phosphatase, placental [KO:K01077] [EC:3.1.3.1]
251  ALPG; alkaline phosphatase, germ cell [KO:K01077] [EC:3.1.3.1]
52  ACP1; acid phosphatase 1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
27010  TPK1; thiamin pyrophosphokinase 1 [KO:K00949] [EC:2.7.6.2]
122481  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
158067  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
203  AK1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
204  AK2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
205  AK4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
26289  AK5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
79178  THTPA; thiamine triphosphatase [KO:K05307] [EC:3.6.1.28]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00230  Purine metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa00270  Cysteine and methionine metabolism
hsa00400  Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

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