Entry Name VEGF signaling pathway - Homo sapiens (human)
Description There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Drug D05029 Midostaurin (JAN/USAN/INN)
D05386 Pegaptanib sodium (JAN/USAN)
D06272 Sorafenib tosylate (USAN)
D06402 Sunitinib malate (JAN/USAN)
D06407 Vandetanib (JAN/USAN/INN)
D08544 Toceranib phosphate (USAN)
D08874 Bevasiranib sodium (USAN)
D08878 Brivanib alaninate (JAN/USAN/INN)
D08883 Cediranib maleate (JAN/USAN)
D08947 Motesanib diphosphate (USAN)
D09603 Dilmapimod tosylate (USAN)
D09665 Saracatinib difumarate (USAN)
D09920 Lenvatinib mesylate (USAN)
D09945 Pegdinetanib (USAN/INN)
D10095 Cabozantinib s-malate (USAN)
D10137 Regorafenib hydrate (JAN)
D10190 Tivozanib hydrochloride (USAN)
D10396 Nintedanib esylate (USAN)
D10465 Golvatinib tartrate (USAN)
D10486 Pimasertib hydrochloride (USAN)
D11083 Brolucizumab (USAN/INN)
D11126 Navicixizumab (USAN/INN)
D11289 Rivoceranib mesylate (USAN)
D11517 Abicipar pegol (USAN/INN)
D12508 Tarcocimab tedromer (INN)
Other DBs Organism Homo sapiens (human) [GN:
hsa ]
Gene 7422 VEGFA; vascular endothelial growth factor A [KO:K05448 ]
3265 HRAS; HRas proto-oncogene, GTPase [KO:K02833 ]
3845 KRAS; KRAS proto-oncogene, GTPase [KO:K07827 ]
4893 NRAS; NRAS proto-oncogene, GTPase [KO:K07828 ]
5534 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
5535 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
4773 NFATC2; nuclear factor of activated T cells 2 [KO:K17332 ]
998 CDC42; cell division cycle 42 [KO:K04393 ]
3315 HSPB1; heat shock protein family B (small) member 1 [KO:K04455 ]
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
572 BAD; BCL2 associated agonist of cell death [KO:K02158 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
Title VEGF-receptor signal transduction.
Journal Reference Authors Matsumoto T, Claesson-Welsh L.
Title VEGF receptor signal transduction.
Journal Reference Authors Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Title Vascular endothelial growth factor and angiogenesis.
Journal Reference Authors Takahashi H, Shibuya M.
Title The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Journal Reference Authors Zachary I.
Title VEGF signalling: integration and multi-tasking in endothelial cell biology.
Journal Reference Authors Munoz-Chapuli R, Quesada AR, Angel Medina M.
Title Angiogenesis and signal transduction in endothelial cells.
Journal Reference Authors Lamalice L, Houle F, Jourdan G, Huot J.
Title Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Journal Reference Authors Shu X, Wu W, Mosteller RD, Broek D.
Title Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Journal Related KO pathway LinkDB All DBs
