Collecting duct acid secretion - Homo sapiens (human)
One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate.
Organismal Systems; Excretory system
Pathway map Ortholog table
D00355 Lansoprazole (JP18/USP/INN)
D00455 Omeprazole (JP18/USP/INN)
D00724 Rabeprazole sodium (JP18/USP)
D01207 Omeprazole sodium (USAN)
D01920 Tenatoprazole (JAN/INN)
D01984 Esomeprazole magnesium (USP)
D02593 Pantoprazole sodium (USP)
D03845 Sezolamide hydrochloride (USAN)
D04056 Esomeprazole sodium (USAN)
D05259 Omeprazole magnesium (USP)
D05261 Omeprazole sodium injection (JAN)
D05353 Pantoprazole (USAN/INN)
D08903 Dexlansoprazole (INN/USAN)
D09339 Esomeprazole potassium (USAN)
D09837 Penaprazole sodium hydrate (JAN)
D10120 Esomeprazole strontium (USAN)
D11114 Esomeprazole magnesium dihydrate
Homo sapiens (human) [GN:
525 ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO: K02147]
526 ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO: K02147]
9550 ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO: K02152]
127124 ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO: K02152]
534 ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO: K02152]
245973 ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO: K02148]
528 ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO: K02148]
51382 ATP6V1D; ATPase H+ transporting V1 subunit D [KO: K02149]
90423 ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO: K02150]
529 ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO: K02150]
9296 ATP6V1F; ATPase H+ transporting V1 subunit F [KO: K02151]
8992 ATP6V0E1; ATPase H+ transporting V0 subunit e1 [KO: K02153]
155066 ATP6V0E2; ATPase H+ transporting V0 subunit e2 [KO: K02153]
10312 TCIRG1; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO: K02154]
23545 ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO: K02154]
50617 ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO: K02154]
535 ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO: K02154]
527 ATP6V0C; ATPase H+ transporting V0 subunit c [KO: K02155]
9114 ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO: K02146]
245972 ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO: K02146]
6521 SLC4A1; solute carrier family 4 member 1 (Diego blood group) [KO: K06573]
10723 SLC12A7; solute carrier family 12 member 7 [KO: K13627]
1188 CLCNKB; chloride voltage-gated channel Kb [KO: K05018]
Wagner CA, Kovacikova J, Stehberger PA, Winter C, Benabbas C, Mohebbi N
Renal acid-base transport: old and new players.
Wagner CA, Devuyst O, Bourgeois S, Mohebbi N
Regulated acid-base transport in the collecting duct.
The kidney and acid-base regulation.
Physiology and pathophysiology of acid-base homeostasis in the kidney.
Fry AC, Karet FE
Inherited renal acidoses.
Pereira PC, Miranda DM, Oliveira EA, Silva AC
Molecular pathophysiology of renal tubular acidosis.
New insights into the pathogenesis of renal tubular acidosis--from functional to molecular studies.
Genetic diseases of acid-base transporters.
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