Endometrial cancer - Homo sapiens (human)
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Human Diseases; Cancer: specific types
Pathway map Ortholog table
N00012 Mutation-activated KRAS/NRAS to ERK signaling pathway
N00052 Mutation-inactivated PTEN to PI3K signaling pathway
N00058 Mutation-activated CTNNB1 to Wnt signaling pathway
N00115 Mutation-inactivated TP53 to transcription
Homo sapiens (human) [GN:
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO: K00922] [EC: 220.127.116.11]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO: K00922] [EC: 18.104.22.168]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO: K00922] [EC: 22.214.171.124]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO: K02649]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO: K02649]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO: K02649]
572 BAD; BCL2 associated agonist of cell death [KO: K02158]
2885 GRB2; growth factor receptor bound protein 2 [KO: K04364]
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO: K03099]
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO: K03099]
3265 HRAS; HRas proto-oncogene, GTPase [KO: K02833]
3845 KRAS; KRAS proto-oncogene, GTPase [KO: K07827]
4893 NRAS; NRAS proto-oncogene, GTPase [KO: K07828]
2002 ELK1; ETS transcription factor ELK1 [KO: K04375]
324 APC; APC regulator of WNT signaling pathway [KO: K02085]
10297 APC2; APC regulator of WNT signaling pathway 2 [KO: K02085]
83439 TCF7L1; transcription factor 7 like 1 [KO: K04490]
6934 TCF7L2; transcription factor 7 like 2 [KO: K04491]
51176 LEF1; lymphoid enhancer binding factor 1 [KO: K04492]
4609 MYC; MYC proto-oncogene, bHLH transcription factor [KO: K04377]
1026 CDKN1A; cyclin dependent kinase inhibitor 1A [KO: K06625]
1647 GADD45A; growth arrest and DNA damage inducible alpha [KO: K04402]
4616 GADD45B; growth arrest and DNA damage inducible beta [KO: K04402]
10912 GADD45G; growth arrest and DNA damage inducible gamma [KO: K04402]
581 BAX; BCL2 associated X, apoptosis regulator [KO: K02159]
578 BAK1; BCL2 antagonist/killer 1 [KO: K14021]
1643 DDB2; damage specific DNA binding protein 2 [KO: K10140]
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Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Shiozawa T, Konishi I.
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
Hecht JL, Mutter GL.
Molecular and pathologic aspects of endometrial carcinogenesis.
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
Molecular pathology of endometrial hyperplasia and carcinoma.
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
Cancer Res 55:5693-8 (1995)
Kim D, Chung J.
Akt: versatile mediator of cell survival and beyond.
hsa04060 Cytokine-cytokine receptor interaction
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