Entry Name Diabetic cardiomyopathy
Description Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class Human Diseases; Cardiovascular diseaseBRITE hierarchy
Pathway map Ortholog table Disease H02498 Diabetic cardiomyopathy
Reference Authors Riehle C, Bauersachs J
Title Of mice and men: models and mechanisms of diabetic cardiomyopathy.
Journal Reference Authors Huynh K, Bernardo BC, McMullen JR, Ritchie RH
Title Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
Journal Reference Authors Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
Title Diagnostic approaches for diabetic cardiomyopathy.
Journal Reference Authors Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
Title Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
Journal Reference Authors Zamora M, Villena JA
Title Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
Journal Reference Authors Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
Title Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
Journal Reference Authors Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
Title Diabetic Cardiomyopathy: An Immunometabolic Perspective.
Journal Reference Authors Chong CR, Clarke K, Levelt E
Title Metabolic Remodeling in Diabetic Cardiomyopathy.
Journal Reference Authors Brownlee M
Title Biochemistry and molecular cell biology of diabetic complications.
Journal Reference Authors Gollmer J, Zirlik A, Bugger H
Title Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
Journal Reference Authors Boudina S, Abel ED
Title Diabetic cardiomyopathy revisited.
Journal Reference Authors Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
Title Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
Journal Reference Authors Mandavia CH, Aroor AR, Demarco VG, Sowers JR
Title Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
Journal Reference Authors Falcao-Pires I, Leite-Moreira AF
Title Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
Journal Reference Authors Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
Title New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
Journal Reference Authors Randhawa VK, Dhanvantari S, Connelly K
Title How Diabetes and Heart Failure Modulate Each Other and Condition Management.
Journal Reference Authors Athithan L, Gulsin GS, McCann GP, Levelt E
Title Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
Journal Reference Authors Murarka S, Movahed MR
Title Diabetic cardiomyopathy.
Journal Reference Authors Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
Title Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
Journal Reference Authors Brahma MK, Pepin ME, Wende AR
Title My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
Journal Reference Authors Singh VP, Le B, Khode R, Baker KM, Kumar R
Title Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
Journal Reference Authors Singh VP, Baker KM, Kumar R
Title Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
Journal Reference Authors Jia G, DeMarco VG, Sowers JR
Title Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Journal Reference Authors Kim JA, Wei Y, Sowers JR
Title Role of mitochondrial dysfunction in insulin resistance.
Journal Reference Authors Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
Title Association between insulin resistance and the development of cardiovascular disease.
Journal Reference Authors Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
Title Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
Journal Reference Authors Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
Title Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
Journal Reference Authors Knapp M, Tu X, Wu R
Title Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
Journal Reference Authors Asbun J, Villarreal FJ
Title The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
Journal Reference Authors Levick SP, Widiapradja A
Title The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
Journal Related map00520 Amino sugar and nucleotide sugar metabolism
map04933 AGE-RAGE signaling pathway in diabetic complications
KO pathway LinkDB All DBs
