KEGG   PATHWAY: mmu04217
Entry
mmu04217                    Pathway                                
Name
Necroptosis - Mus musculus (house mouse)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
mmu04217  Necroptosis
mmu04217

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100039319  H2ab1; H2A.B variant histone 1 [KO:K11251]
100042840  H2al2b; H2A histone family member L2B [KO:K11251]
100042922  H2al1a; H2A histone family member L1A [KO:K11251]
100042927  H2al1b; H2A histone family member L1B [KO:K11251]
100042929  H2al1c; H2A histone family member L1C [KO:K11251]
100042931  H2al1d; H2A histone family member L1D [KO:K11251]
100042939  H2al1f; H2A histone family member L1F [KO:K11251]
100042943  H2al1g; H2A histone family member L1G [KO:K11251]
100042944  H2al1h; H2A histone family member L1H [KO:K11251]
100042946  H2al1i; H2A histone family member L1I [KO:K11251]
102641752  Gm38574; predicted gene, 38574 [KO:K10802]
105513  Chmp7; charged multivesicular body protein 7 [KO:K15053]
106025  Sharpin; SHANK-associated RH domain interacting protein [KO:K20894]
106759  Ticam1; TIR domain containing adaptor molecule 1 [KO:K05842]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
110078  Pygb; brain glycogen phosphorylase [KO:K00688] [EC:2.4.1.1]
110095  Pygl; liver glycogen phosphorylase [KO:K00688] [EC:2.4.1.1]
11545  Parp1; poly (ADP-ribose) polymerase family, member 1 [KO:K24070] [EC:2.4.2.30]
116733  Vps4a; vacuolar protein sorting 4A [KO:K12196]
11687  Alox15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
11796  Birc3; baculoviral IAP repeat-containing 3 [KO:K16060]
11797  Birc2; baculoviral IAP repeat-containing 2 [KO:K16060]
11798  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
12028  Bax; BCL2-associated X protein [KO:K02159]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12122  Bid; BH3 interacting domain death agonist [KO:K04726]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12333  Capn1; calpain 1 [KO:K01367] [EC:3.4.22.52]
12334  Capn2; calpain 2 [KO:K03853] [EC:3.4.22.53]
12362  Casp1; caspase 1 [KO:K01370] [EC:3.4.22.36]
12370  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
12633  Cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
14082  Fadd; Fas associated via death domain [KO:K02373]
14102  Fas; Fas cell surface death receptor [KO:K04390]
14103  Fasl; Fas ligand [KO:K04389]
142980  Tlr3; toll-like receptor 3 [KO:K05401]
14319  Fth1; ferritin heavy polypeptide 1 [KO:K00522] [EC:1.16.3.1]
14325  Ftl1; ferritin light polypeptide 1 [KO:K13625]
14645  Glul; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
14661  Glud1; glutamate dehydrogenase 1 [KO:K00261] [EC:1.4.1.3]
15267  H2ac18; H2A clustered histone 18 [KO:K11251]
15270  H2ax; H2A.X variant histone [KO:K11251]
15289  Hmgb1; high mobility group box 1 [KO:K10802]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
15962  Ifna1; interferon alpha 1 [KO:K05414]
15964  Ifna11; interferon alpha 11 [KO:K05414]
15965  Ifna2; interferon alpha 2 [KO:K05414]
15967  Ifna4; interferon alpha 4 [KO:K05414]
15968  Ifna5; interferon alpha 5 [KO:K05414]
15969  Ifna6; interferon alpha 6 [KO:K05414]
15970  Ifna7; interferon alpha 7 [KO:K05414]
15972  Ifna9; interferon alpha 9 [KO:K05414]
15974  Ifnab; interferon alpha B [KO:K05414]
15975  Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976  Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
15977  Ifnb1; interferon beta 1, fibroblast [KO:K05415]
15978  Ifng; interferon gamma [KO:K04687]
15979  Ifngr1; interferon gamma receptor 1 [KO:K05132]
15980  Ifngr2; interferon gamma receptor 2 [KO:K05133]
16175  Il1a; interleukin 1 alpha [KO:K04383]
16176  Il1b; interleukin 1 beta [KO:K04519]
16391  Irf9; interferon regulatory factor 9 [KO:K04693]
16451  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
18412  Sqstm1; sequestosome 1 [KO:K14381]
18783  Pla2g4a; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
19106  Eif2ak2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
19309  Pygm; muscle glycogen phosphorylase [KO:K00688] [EC:2.4.1.1]
19766  Ripk1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
20479  Vps4b; vacuolar protein sorting 4B [KO:K12196]
20597  Smpd1; sphingomyelin phosphodiesterase 1, acid lysosomal [KO:K12350] [EC:3.1.4.12]
208092  Chmp6; charged multivesicular body protein 6 [KO:K12195]
20846  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20849  Stat4; signal transducer and activator of transcription 4 [KO:K11222]
20850  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
20852  Stat6; signal transducer and activator of transcription 6 [KO:K11225]
211429  Pla2g4b; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
216799  Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800]
21898  Tlr4; toll-like receptor 4 [KO:K10160]
21926  Tnf; tumor necrosis factor [KO:K03156]
21929  Tnfaip3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
21933  Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b [KO:K04722]
21937  Tnfrsf1a; tumor necrosis factor receptor superfamily, member 1a [KO:K03158]
22030  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
22033  Traf5; TNF receptor-associated factor 5 [KO:K09849]
22035  Tnfsf10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
225471  Ticam2; TIR domain containing adaptor molecule 2 [KO:K05409]
230396  Ifna13; interferon alpha 13 [KO:K05414]
230398  Ifna16; interferon alpha 16 [KO:K05414]
232440  H2aj; H2J.A histone [KO:K11251]
232889  Pla2g4c; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
234852  Chmp1a; charged multivesicular body protein 1A [KO:K12197]
236663  H2al1j; H2A histone family member L1J [KO:K11251]
24105  Rbck1; RanBP-type and C3HC4-type zinc finger containing 1 [KO:K10630] [EC:2.3.2.31]
242517  Ifna15; interferon alpha 15 [KO:K05414]
242519  Ifna12; interferon alpha 12 [KO:K05414]
263876  Spata2; spermatogenesis associated 2 [KO:K17595]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
268373  Ppia; peptidylprolyl isomerase A [KO:K03767] [EC:5.2.1.8]
268749  Rnf31; ring finger protein 31 [KO:K11974] [EC:2.3.2.31]
26914  Macroh2a1; macroH2A.1 histone [KO:K11251]
26926  Aifm1; apoptosis-inducing factor, mitochondrion-associated 1 [KO:K04727] [EC:1.-.-.-]
271844  Pla2g4f; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
30941  Usp21; ubiquitin specific peptidase 21 [KO:K21634] [EC:3.4.19.12]
319162  H2ac25; H2A clustered histone 25 [KO:K11251]
319163  H2ac1; H2A clustered histone 1 [KO:K11251]
319164  H2ac6; H2A clustered histone 6 [KO:K11251]
319165  H2ac7; H2A clustered histone 7 [KO:K11251]
319166  H2ac8; H2A clustered histone 8 [KO:K11251]
319167  H2ac11; H2A clustered histone 11 [KO:K11251]
319168  H2ac12; H2A clustered histone 12 [KO:K11251]
319169  H2ac15; H2A clustered histone 15 [KO:K11251]
319170  H2ac22; H2A clustered histone 22 [KO:K11251]
319171  H2ac24; H2A clustered histone 24 [KO:K11251]
319172  H2ac4; H2A clustered histone 4 [KO:K11251]
319173  H2ac10; H2A clustered histone 10 [KO:K11251]
319176  H2ac20; H2A clustered histone 20 [KO:K11251]
319191  H2ac13; H2A clustered histone 13 [KO:K11251]
319192  H2ac19; H2A clustered histone 19 [KO:K11251]
329502  Pla2g4e; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
333452  H2al1o; H2A histone family member L1O [KO:K11251]
385317  H2al3; H2A histone family member L3 [KO:K11251]
385328  H2al1n; H2A histone family member L1N [KO:K11251]
385454  Gm5396; predicted pseudogene 5396 [KO:K10802]
404549  Ifna14; interferon alpha 14 [KO:K05414]
404634  Macroh2a2; macroH2A.2 histone [KO:K11251]
434624  Ftl1-ps2; ferritin light polypeptide, pseudogene 2 [KO:K13625]
51788  H2az1; H2A.Z variant histone 1 [KO:K11251]
547154  H2al1k; H2A histone family member L1K [KO:K11251]
547160  H2al1e; H2A histone family member L1E [KO:K11251]
54721  Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
547210  H2al2c; H2A histone family member L2C [KO:K11251]
56532  Ripk3; receptor-interacting serine-threonine kinase 3 [KO:K08847] [EC:2.7.11.1]
58203  Zbp1; Z-DNA binding protein 1 [KO:K12965]
58800  Trpm7; transient receptor potential cation channel, subfamily M, member 7 [KO:K04982] [EC:2.7.11.1]
621893  H2ac21; H2A clustered histone 21 [KO:K11251]
624153  H2ab2; H2A.B variant histone 2 [KO:K11251]
624957  H2ab3; H2A.B variant histone 3 [KO:K11251]
66371  Chmp4c; charged multivesicular body protein 4C [KO:K24782]
665433  H2ac23; H2A clustered histone 23 [KO:K11251]
66700  Chmp3; charged multivesicular body protein 3 [KO:K12193]
66824  Pycard; PYD and CARD domain containing [KO:K12799]
668548  Gm9234; predicted pseudogene 9234 [KO:K03767] [EC:5.2.1.8]
67028  Chmp1b2; charged multivesicular body protein 1B2 [KO:K12197]
67064  Chmp1b; charged multivesicular body protein 1B [KO:K12197]
67738  Ppid; peptidylprolyl isomerase D (cyclophilin D) [KO:K05864] [EC:5.2.1.8]
68231  H2al2a; H2A histone family member L2A [KO:K11251]
68942  Chmp2b; charged multivesicular body protein 2B [KO:K12192]
68953  Chmp2a; charged multivesicular body protein 2A [KO:K12191]
71609  Tradd; TNFRSF1A-associated via death domain [KO:K03171]
72542  Pgam5; phosphoglycerate mutase family member 5 [KO:K15637] [EC:3.1.3.16]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
74006  Dnm1l; dynamin 1-like [KO:K17065] [EC:3.6.5.5]
74256  Cyld; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
74568  Mlkl; mixed lineage kinase domain-like [KO:K08849] [EC:2.7.11.1]
75608  Chmp4b; charged multivesicular body protein 4B [KO:K12194]
76383  H2al1m; H2A histone family member L1M [KO:K11251]
76959  Chmp5; charged multivesicular body protein 5 [KO:K12198]
77125  Il33; interleukin 33 [KO:K12967]
77605  H2az2; H2A.Z histone variant 2 [KO:K11251]
78390  Pla2g4d; phospholipase A2, group IVD [KO:K16342] [EC:3.1.1.4]
78779  Spata2l; spermatogenesis associated 2-like [KO:K17595]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
mmu00250  Alanine, aspartate and glutamate metabolism
mmu04210  Apoptosis
mmu04668  TNF signaling pathway
mmu04922  Glucagon signaling pathway
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system