KEGG   PATHWAY: mmu04672
Entry
mmu04672                    Pathway                                
Name
Intestinal immune network for IgA production - Mus musculus (house mouse)
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
Pathway map
mmu04672  Intestinal immune network for IgA production
mmu04672

Other DBs
GO: 0002387
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
12519  Cd80; CD80 antigen [KO:K05412]
12524  Cd86; CD86 antigen [KO:K05413]
14960  H2-Aa; histocompatibility 2, class II antigen A, alpha [KO:K06752]
14961  H2-Ab1; histocompatibility 2, class II antigen A, beta 1 [KO:K06752]
14969  H2-Eb1; histocompatibility 2, class II antigen E beta [KO:K06752]
14998  H2-DMa; histocompatibility 2, class II, locus DMa [KO:K06752]
14999  H2-DMb1; histocompatibility 2, class II, locus Mb1 [KO:K06752]
15000  H2-DMb2; histocompatibility 2, class II, locus Mb2 [KO:K06752]
15001  H2-Oa; histocompatibility 2, O region alpha locus [KO:K06752]
15002  H2-Ob; histocompatibility 2, O region beta locus [KO:K06752]
100504404  H2-Ea; histocompatibility 2, class II antigen E alpha [KO:K06752]
381091  H2-Eb2; histocompatibility 2, class II antigen E beta2 [KO:K06752]
12487  Cd28; CD28 antigen [KO:K06470]
16183  Il2; interleukin 2 [KO:K05429]
16189  Il4; interleukin 4 [KO:K05430]
16191  Il5; interleukin 5 [KO:K05428]
16193  Il6; interleukin 6 [KO:K05405]
16153  Il10; interleukin 10 [KO:K05443]
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
69583  Tnfsf13; tumor necrosis factor (ligand) superfamily, member 13 [KO:K05475]
24099  Tnfsf13b; tumor necrosis factor (ligand) superfamily, member 13b [KO:K05476]
57916  Tnfrsf13b; tumor necrosis factor receptor superfamily, member 13b [KO:K05150]
21935  Tnfrsf17; tumor necrosis factor receptor superfamily, member 17 [KO:K05153]
72049  Tnfrsf13c; tumor necrosis factor receptor superfamily, member 13c [KO:K05151]
11628  Aicda; activation-induced cytidine deaminase [KO:K10989] [EC:3.5.4.38]
21939  Cd40; CD40 antigen [KO:K03160]
21947  Cd40lg; CD40 ligand [KO:K03161]
54167  Icos; inducible T cell co-stimulator [KO:K06713]
50723  Icosl; icos ligand [KO:K06710]
12769  Ccr9; chemokine (C-C motif) receptor 9 [KO:K04184]
16401  Itga4; integrin alpha 4 [KO:K06483]
16421  Itgb7; integrin beta 7 [KO:K06590]
20315  Cxcl12; chemokine (C-X-C motif) ligand 12 [KO:K10031]
12767  Cxcr4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
56838  Ccl28; chemokine (C-C motif) ligand 28 [KO:K05513]
12777  Ccr10; chemokine (C-C motif) receptor 10 [KO:K04185]
20300  Ccl25; chemokine (C-C motif) ligand 25 [KO:K13072]
17123  Madcam1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
17000  Ltbr; lymphotoxin B receptor [KO:K03159]
53859  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
16168  Il15; interleukin 15 [KO:K05433]
16169  Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
18703  Pigr; polymeric immunoglobulin receptor [KO:K13073]
Compound
C00777  Retinoate
C15493  9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322
Related
pathway
mmu04612  Antigen processing and presentation
mmu04660  T cell receptor signaling pathway
mmu04662  B cell receptor signaling pathway
mmu04670  Leukocyte transendothelial migration
KO pathway
ko04672   
LinkDB

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