KEGG   PATHWAY: mna05330
Entry
mna05330                    Pathway                                

Name
Allograft rejection - Miniopterus natalensis
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
Pathway map
mna05330  Allograft rejection
mna05330

Organism
Miniopterus natalensis [GN:mna]
Gene
107538488  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
107538961  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107525813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107546126  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
107546127  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like [KO:K06751]
107528441  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
107531685  uncharacterized protein LOC107531685 [KO:K10784]
107527336  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
107527343  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
107524832  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
107539273  IL12A; interleukin-12 subunit alpha [KO:K05406]
107537877  IL12B; interleukin-12 subunit beta [KO:K05425]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107526074  PRF1; perforin-1 [KO:K07818]
107544835  granzyme B-like [KO:K01353] [EC:3.4.21.79]
107544836  granzyme H-like [KO:K01353] [EC:3.4.21.79]
107545174  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107536419  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
107544122  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107542667  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
107542672  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
107542674  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
107545091  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107545092  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
107529760  IL2; interleukin-2 [KO:K05429]
107539933  CD40LG; CD40 ligand [KO:K03161]
107530873  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
107527227  IFNG; interferon gamma [KO:K04687]
107538974  TNF; tumor necrosis factor [KO:K03156]
107525027  IL4; interleukin-4 [KO:K05430]
107525025  IL5; interleukin-5 [KO:K05428]
107539442  IL10; interleukin-10 [KO:K05443]
Compound
C00533  Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
Related
pathway
mna04210  Apoptosis
mna04514  Cell adhesion molecules
mna04610  Complement and coagulation cascades
mna04612  Antigen processing and presentation
mna04660  T cell receptor signaling pathway
mna04662  B cell receptor signaling pathway
KO pathway
ko05330   
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