KEGG   PATHWAY: ocu04060
ocu04060                    Pathway                                
Cytokine-cytokine receptor interaction - Oryctolagus cuniculus (rabbit)
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ocu04060  Cytokine-cytokine receptor interaction

Oryctolagus cuniculus (rabbit) [GN:ocu]
103351518  CCL1; C-C motif chemokine ligand 1 [KO:K05514]
100337936  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
100348362  CCL19; C-C motif chemokine ligand 19 [KO:K05512]
100144337  CCL21; C-C motif chemokine ligand 21 [KO:K16062]
100348776  CCL3; C-C motif chemokine 3-like 1 [KO:K05408]
100008984  CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
103348470  CCL17; C-C motif chemokine ligand 17 [KO:K21083]
103348469  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
100348266  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
100348517  CCL14; C-C motif chemokine ligand 14 [KO:K21092]
103351619  CCL16; C-C motif chemokine 16 [KO:K21093]
103351523  C-C motif chemokine 15 [KO:K05511]
103351522  C-C motif chemokine 23 [KO:K05511]
100343840  CCL7; chemokine (C-C motif) ligand 7 [KO:K05509]
100009130  CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
107546750  CCL11; chemokine (C-C motif) ligand 11 [KO:K16597]
100354652  C-C motif chemokine 24 [KO:K21097]
100355784  CCL24; C-C motif chemokine ligand 24 [KO:K21097]
100348869  CCL27; C-C motif chemokine ligand 27 [KO:K16598]
108176349  uncharacterized LOC108176349 [KO:K16598]
103349663  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
100303767  C-C motif chemokine 28 [KO:K05513]
103348897  CCL20; C-C motif chemokine ligand 20 [KO:K14625]
100009192  GRO-G; GRO gamma protein [KO:K05505]
100328583  GRO-B; GRO beta protein [KO:K05505]
100009245  GRO-A; GRO [KO:K05505]
100008716  ENA-78; alveolar macrophage chemotactic factor-like [KO:K05506]
100009129  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103350825  PPBP; pro-platelet basic protein [KO:K10029]
100008921  platelet microbicidal protein 1 [KO:K05407]
103350772  CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
100353112  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
100340593  CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
100144333  CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
103345545  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100348428  CXCL16; C-X-C motif chemokine ligand 16 [KO:K10035]
103345447  CXCL17; C-X-C motif chemokine ligand 17 [KO:K22627]
100349255  lymphotactin [KO:K05507]
100346186  CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
100302458  IL2; interleukin 2 [KO:K05429]
100302454  IL4; interleukin 4 [KO:K05430]
100345409  IL7; interleukin 7 [KO:K05431]
100340820  IL9; interleukin 9 [KO:K05432]
100009017  IL15; interleukin 15 [KO:K05433]
100344172  IL21; interleukin 21 [KO:K05434]
103349580  TSLP; thymic stromal lymphopoietin [KO:K05436]
100358075  IL5; interleukin 5 [KO:K05428]
100328720  CSF2; colony stimulating factor 2 [KO:K05427]
100358676  IL13; interleukin 13 [KO:K05435]
100008786  EPO; erythropoietin [KO:K05437]
100356068  GH1; somatotropin [KO:K05438]
100009394  PRL; prolactin [KO:K05439]
100357079  THPO; thrombopoietin [KO:K06854]
100356652  CSF3; colony stimulating factor 3 [KO:K05423]
100008747  LEP; leptin [KO:K05424]
100008733  IL6; interleukin 6 [KO:K05405]
100349007  IL12A; interleukin 12A [KO:K05406]
100354852  IL12B; interleukin 12B [KO:K05425]
100352065  IL23A; interleukin 23 subunit alpha [KO:K05426]
100349321  IL27; interleukin 27 [KO:K22629]
100356265  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
100009117  CNTF; ciliary neurotrophic factor [KO:K05420]
100354643  CTF1; cardiotrophin-1 [KO:K05422]
108175610  cardiotrophin-2 [KO:K24382]
100358914  LIF; leukemia inhibitory factor [KO:K05419]
100342491  OSM; oncostatin M [KO:K05418]
100008701  IL10; interleukin 10 [KO:K05443]
100353950  IL19; interleukin 19 [KO:K05444]
100353705  IL20; interleukin 20 [KO:K22667]
100348980  IL22; interleukin 22 [KO:K05445]
100348730  IL26; interleukin 26 [KO:K05446]
100341420  interferon lambda-1-like [KO:K05447]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13-like [KO:K05414]
100342931  IFNB1; interferon beta 1 [KO:K05415]
100353137  interferon omega-1-like [KO:K05440]
100353640  interferon omega-1-like [KO:K05440]
100353888  interferon omega-1-like [KO:K05440]
100354910  interferon omega-1-like [KO:K05440]
100355421  interferon omega-1-like [KO:K05440]
100358223  interferon omega-1-like [KO:K05440]
100354397  interferon omega-1-like [KO:K05440]
100356937  interferon omega-1-like [KO:K05440]
100357452  interferon omega-1-like [KO:K05440]
100348954  IFNK; interferon kappa [KO:K05441]
100341910  IFNE; interferon epsilon [KO:K05442]
100008602  IFNG; interferon gamma [KO:K04687]
100009250  IL1A; interleukin 1 alpha [KO:K04383]
100008990  IL1B; interleukin 1 beta [KO:K04519]
100009558  IL1RN; interleukin 1 receptor antagonist [KO:K05481]
100340988  IL36RN; interleukin 36 receptor antagonist [KO:K05483]
100355520  IL36A; interleukin 36, alpha [KO:K05484]
100355269  IL36G; interleukin 36, gamma [KO:K05487]
100341760  IL1F10; interleukin 1 family member 10 (theta) [KO:K05488]
103347619  IL37; interleukin 37 [KO:K05485]
100144338  IL18; interleukin 18 [KO:K05482]
100356081  IL33; interleukin 33 [KO:K12967]
100339322  IL17A; interleukin 17A [KO:K05489]
100339570  IL17F; interleukin 17F [KO:K05494]
100341848  IL17B; interleukin 17B [KO:K05490]
103349030  IL17D; interleukin 17D [KO:K05492]
100345869  IL25; interleukin 25 [KO:K05493]
100356333  IL16; interleukin 16 [KO:K22628]
103345669  IL32; interleukin 32 [KO:K22632]
100347811  IL34; interleukin 34 [KO:K22633]
100338577  CSF1; colony stimulating factor 1 [KO:K05453]
100009088  TNF; tumor necrosis factor [KO:K03156]
100328931  LTA; lymphotoxin alpha [KO:K05468]
100144336  LTB; lymphotoxin beta [KO:K03157]
100347876  TNFSF14; tumor necrosis factor superfamily member 14 [KO:K05477]
100344073  FASLG; Fas ligand [KO:K04389]
100342334  TNFSF15; tumor necrosis factor superfamily member 15 [KO:K05478]
100355808  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
100340021  EDA; ectodysplasin A [KO:K05480]
103350089  NGF; nerve growth factor [KO:K02582]
100341009  TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
100356651  TNFSF12; tumor necrosis factor (ligand) superfamily, member 12 [KO:K05474]
100348799  CD70; CD70 molecule [KO:K05470]
100342081  TNFSF8; tumor necrosis factor superfamily member 8 [KO:K05471]
100358388  CD40LG; CD40 ligand [KO:K03161]
100008595  TNFSF4; tumor necrosis factor superfamily member 4 [KO:K05469]
100354793  TNFSF18; tumor necrosis factor superfamily member 18 [KO:K05479]
100126074  TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
100101577  TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
103345451  transforming growth factor beta-1 [KO:K13375]
108175468  transforming growth factor beta-1-like [KO:K13375]
100352552  transforming growth factor beta-1 [KO:K13375]
100352810  transforming growth factor beta-1 [KO:K13375]
103345452  transforming growth factor beta-1-like [KO:K13375]
100352301  transforming growth factor beta-1 [KO:K13375]
100353067  transforming growth factor beta-1 [KO:K13375]
103345448  transforming growth factor beta-1 [KO:K13375]
100008645  TGFB1; transforming growth factor beta-1 [KO:K13375]
100009371  TGFB2; transforming growth factor beta 2 [KO:K13376]
100358982  TGFB3; transforming growth factor beta 3 [KO:K13377]
100351972  GDF2; growth differentiation factor 2 [KO:K05503]
100357896  BMP10; bone morphogenetic protein 10 [KO:K22670]
100328899  INHA; inhibin alpha subunit [KO:K05500]
100348414  BMP3; bone morphogenetic protein 3 [KO:K05496]
100351716  GDF10; growth differentiation factor 10 [KO:K22674]
100341680  GDF11; growth differentiation factor 11 [KO:K22679]
100125998  MSTN; myostatin [KO:K05497]
100354786  INHBA; inhibin beta A subunit [KO:K04667]
100341426  INHBB; inhibin beta B subunit [KO:K22687]
100346534  GDF3; growth differentiation factor 3 [KO:K22672]
103349623  nodal homolog 2-A [KO:K22672]
100342652  NODAL; nodal growth differentiation factor [KO:K04666]
100328727  GDF9; growth differentiation factor 9 [KO:K22673]
100358469  INHBC; inhibin beta C subunit [KO:K22688]
100358730  INHBE; inhibin beta E subunit [KO:K22689]
100009349  BMP2; bone morphogenetic protein 2 [KO:K21283]
108175367  bone morphogenetic protein 2-like [KO:K21283]
100009569  BMP4; bone morphogenetic protein 4 [KO:K04662]
100328897  GDF5; growth differentiation factor 5 [KO:K04664]
100355026  GDF6; growth differentiation factor 6 [KO:K20012]
100339215  GDF7; growth differentiation factor 7 [KO:K20013]
100355411  BMP15; bone morphogenetic protein 15 [KO:K05498]
100344917  BMP5; bone morphogenetic protein 5 [KO:K04663]
100354948  BMP6; bone morphogenetic protein 6 [KO:K16620]
103347033  bone morphogenetic protein 7 [KO:K16621]
103350213  BMP8B; bone morphogenetic protein 8A [KO:K16622]
100341360  BMP8A; bone morphogenetic protein 8B [KO:K16622]
100345500  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
100144329  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
100352521  ACKR4; atypical chemokine receptor 4 [KO:K04186]
100338432  CCR7; C-C motif chemokine receptor 7 [KO:K04182]
100347328  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
100101579  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
100189557  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
100358097  CCR2; C-C motif chemokine receptor 2 [KO:K04177]
100328940  CCR1; chemokine (C-C motif) receptor 1 [KO:K04176]
100144330  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
100339537  CCR6; C-C motif chemokine receptor 6 [KO:K04181]
100328622  CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
100328627  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
100349863  CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
100144335  CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
100346189  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100354655  ACKR3; atypical chemokine receptor 3 [KO:K04304]
103349210  CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
100352332  XCR1; X-C motif chemokine receptor 1 [KO:K04193]
100008874  CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
100358489  interleukin-2 receptor subunit alpha [KO:K05068]
100338113  interleukin-2 receptor subunit alpha [KO:K05068]
103351862  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
100337721  IL4R; interleukin 4 receptor [KO:K05071]
100343726  IL7R; interleukin 7 receptor [KO:K05072]
100356855  IL9R; interleukin 9 receptor [KO:K05073]
100358749  interleukin-15 receptor subunit alpha [KO:K05074]
100359262  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
103348594  IL21R; interleukin 21 receptor [KO:K05075]
103352517  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
103345135  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
100349996  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
100347606  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
100346676  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
100351788  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
100348025  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
100355350  EPOR; erythropoietin receptor [KO:K05079]
100009325  GHR; growth hormone receptor [KO:K05080]
100009046  PRLR; prolactin receptor [KO:K05081]
100355135  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
100342746  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100351924  LEPR; leptin receptor [KO:K05062]
100347752  IL6R; interleukin 6 receptor [KO:K05055]
100349330  IL6ST; interleukin 6 signal transducer [KO:K05060]
103351784  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
100350416  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
100350917  IL23R; interleukin 23 receptor [KO:K05065]
103347059  IL27RA; interleukin 27 receptor subunit alpha [KO:K19598]
100347492  IL31RA; interleukin 31 receptor A [KO:K22630]
100349367  CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
100303762  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
100356631  OSMR; oncostatin M receptor [KO:K05057]
100354902  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
100338351  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
100341271  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
100349338  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
100344077  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
100356641  IFNLR1; interferon lambda receptor 1 [KO:K05140]
100338604  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
100338097  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100341787  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100338854  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100352905  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
100341281  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
100344048  IL1R2; interleukin 1 receptor type 2 [KO:K04387]
100343547  IL1RL2; interleukin 1 receptor like 2 [KO:K05172]
100303768  IL18R1; interleukin 18 receptor 1 [KO:K05173]
100343288  IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
100350150  IL1RL1; interleukin 1 receptor like 1 [KO:K05171]
100355862  IL17RA; interleukin 17 receptor A [KO:K05164]
100350539  IL17RC; interleukin 17 receptor C [KO:K05166]
100350821  IL17RB; interleukin 17 receptor B [KO:K05165]
100350794  IL17RE; interleukin 17 receptor E [KO:K05168]
100009152  CD4; CD4 molecule [KO:K06454]
100340992  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:]
100346106  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
100349872  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
100346624  LTBR; lymphotoxin beta receptor [KO:K03159]
100008609  FAS; Fas cell surface death receptor [KO:K04390]
108176138  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100349758  TNFRSF21; TNF receptor superfamily member 21 [KO:K05157]
100358332  EDAR; ectodysplasin A receptor [KO:K05162]
100355079  EDA2R; ectodysplasin A2 receptor [KO:K05163]
100349095  NGFR; nerve growth factor receptor [KO:K02583]
100348133  TNFRSF11B; TNF receptor superfamily member 11b [KO:K05148]
100358260  TNFRSF11A; TNF receptor superfamily member 11a [KO:K05147]
103345667  TNFRSF12A; TNF receptor superfamily member 12A [KO:K05149]
100346881  CD27; CD27 molecule [KO:K05144]
100352108  TNFRSF8; TNF receptor superfamily member 8 [KO:K05145]
100349106  CD40; CD40 molecule [KO:K03160]
100348914  TNFRSF9; TNF receptor superfamily member 9 [KO:K05146]
100340653  TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
100341235  TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
100350951  TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
100340235  TNFRSF19; TNF receptor superfamily member 19 [KO:K05155]
100357800  RELT; RELT tumor necrosis factor receptor [KO:K05156]
100345812  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:]
100344335  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:]
100344814  ACVRL1; activin A receptor like type 1 [KO:K13594] [EC:]
100350246  BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:]
100008631  ACVR2A; activin A receptor type 2A [KO:K13596] [EC:]
103347244  ACVR2B; activin A receptor type 2B [KO:K13596] [EC:]
100345068  ACVR1B; activin A receptor type 1B [KO:K13567] [EC:]
100357061  ACVR1C; activin A receptor type 1C [KO:K13568] [EC:]
100355119  ACVR1; activin A receptor type 1 [KO:K04675] [EC:]
100009599  AMHR2; anti-Mullerian hormone receptor type 2 [KO:K04672] [EC:]
100350518  BMPR1A; bone morphogenetic protein receptor type 1A [KO:K04673] [EC:]
100351275  BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:]
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Biochim Biophys Acta 1843:2563-2582 (2014)
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Evolutionary divergence and functions of the human interleukin (IL) gene family.
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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
J Allergy Clin Immunol 138:984-1010 (2016)
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Shared cytokine signaling receptors: structural insights from the gp130 system.
Adv Protein Chem 68:107-46 (2004)
Allan SM, Tyrrell PJ, Rothwell NJ
Interleukin-1 and neuronal injury.
Nat Rev Immunol 5:629-40 (2005)
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Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Front Immunol 4:181 (2013)
Iwakura Y, Ishigame H, Saijo S, Nakae S
Functional specialization of interleukin-17 family members.
Immunity 34:149-62 (2011)
Fischer P, Hilfiker-Kleiner D
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Basic Res Cardiol 102:279-97 (2007)
Richards CD
The enigmatic cytokine oncostatin m and roles in disease.
ISRN Inflamm 2013:512103 (2013)
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Structures and biological functions of IL-31 and IL-31 receptors.
Cytokine Growth Factor Rev 19:347-56 (2008)
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Biochem J 434:343-51 (2011)
de Weerd NA, Nguyen T
The interferons and their receptors--distribution and regulation.
Immunol Cell Biol 90:483-91 (2012)
Aggarwal BB
Signalling pathways of the TNF superfamily: a double-edged sword.
Nat Rev Immunol 3:745-56 (2003)
Ashkenazi A
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Nat Rev Cancer 2:420-30 (2002)
Seeger P, Musso T, Sozzani S
The TGF-beta superfamily in dendritic cell biology.
Cytokine Growth Factor Rev 26:647-57 (2015)
Wakefield LM, Hill CS
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Nat Rev Cancer 13:328-41 (2013)
Mueller TD, Nickel J
Promiscuity and specificity in BMP receptor activation.
FEBS Lett 586:1846-59 (2012)
KO pathway

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