KEGG   PATHWAY: ocu04672
Entry
ocu04672                    Pathway                                
Name
Intestinal immune network for IgA production - Oryctolagus cuniculus (rabbit)
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
Pathway map
ocu04672  Intestinal immune network for IgA production
ocu04672

Other DBs
GO: 0002387
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100009377  CD80; CD80 molecule [KO:K05412]
100008999  CD86; CD86 molecule [KO:K05413]
100328929  RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha [KO:K06752]
100348904  RLA-DRB1; HLA class II histocompatibility antigen, DRB1-8 beta chain [KO:K06752]
100349408  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
100349667  HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752]
100350656  RLA-DRB1; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
100350168  Orcu-DRB; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752]
100343144  Orcu-DQA; SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
100351163  RLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100351416  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100341358  RLA class II histocompatibility antigen, DP beta chain [KO:K06752]
100352927  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
100352672  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100355948  RLA-DMB; histocompatibility antigen DM heterodimer light chain-like [KO:K06752]
100352415  RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like [KO:K06752]
100008998  CD28; CD28 molecule [KO:K06470]
108175645  uncharacterized LOC108175645 [KO:K10785]
100302458  IL2; interleukin 2 [KO:K05429]
100302454  IL4; interleukin 4 [KO:K05430]
100358075  IL5; interleukin 5 [KO:K05428]
100008733  IL6; interleukin 6 [KO:K05405]
100008701  IL10; interleukin 10 [KO:K05443]
103345451  transforming growth factor beta-1 [KO:K13375]
108175468  transforming growth factor beta-1-like [KO:K13375]
100352552  transforming growth factor beta-1 [KO:K13375]
100352810  transforming growth factor beta-1 [KO:K13375]
103345452  transforming growth factor beta-1-like [KO:K13375]
100352301  transforming growth factor beta-1 [KO:K13375]
100353067  transforming growth factor beta-1 [KO:K13375]
103345448  transforming growth factor beta-1 [KO:K13375]
100008645  TGFB1; transforming growth factor beta-1 [KO:K13375]
100126074  TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
100101577  TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
100341235  TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
100340653  TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
100350951  TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
100009097  IGGC; Ig gamma chain C region [KO:K06856]
103345968  uncharacterized LOC103345968 [KO:K06856]
103345969  uncharacterized LOC103345969 [KO:K06856]
103345989  IGH; Ig heavy chain V-III region 23 [KO:K06856]
103347021  Ig heavy chain Mem5-like [KO:K06856]
100353656  uncharacterized LOC100353656 [KO:K06856]
103347220  IGHM; uncharacterized LOC103347220 [KO:K06856]
103346899  uncharacterized LOC103346899 [KO:K06856]
100351810  uncharacterized LOC100351810 [KO:K06856]
100353328  Ig heavy chain V-II region SESS [KO:K06856]
103347112  uncharacterized LOC103347112 [KO:K06856]
100352996  IGHM; Ig heavy chain V-III region 23 [KO:K06856]
100008969  AICDA; activation induced cytidine deaminase [KO:K10989] [EC:3.5.4.38]
100349106  CD40; CD40 molecule [KO:K03160]
100358388  CD40LG; CD40 ligand [KO:K03161]
100352250  ICOS; inducible T-cell costimulator [KO:K06713]
100144329  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
100346103  ITGA4; integrin subunit alpha 4 [KO:K06483]
100350557  ITGB7; integrin subunit beta 7 [KO:K06590]
103345545  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100346189  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
103349663  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
100303767  C-C motif chemokine 28 [KO:K05513]
100144330  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
100337936  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
103347357  MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
100346624  LTBR; lymphotoxin beta receptor [KO:K03159]
100351032  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100009017  IL15; interleukin 15 [KO:K05433]
100358749  interleukin-15 receptor subunit alpha [KO:K05074]
100359262  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100328593  PIGR; polymeric immunoglobulin receptor [KO:K13073]
Compound
C00777  Retinoate
C15493  9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322
Related
pathway
ocu04612  Antigen processing and presentation
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04670  Leukocyte transendothelial migration
KO pathway
ko04672   
LinkDB

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