Entry Name Intestinal immune network for IgA production - Oryctolagus cuniculus (rabbit)
Description The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ocu04672 Intestinal immune network for IgA production
Ortholog table Other DBs Organism Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene 100328929 RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha [KO:K06752 ]
100348904 RLA-DRB1; HLA class II histocompatibility antigen, DRB1-8 beta chain [KO:K06752 ]
100349408 HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752 ]
100349667 HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752 ]
100350656 RLA-DRB1; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752 ]
100350168 Orcu-DRB; HLA class II histocompatibility antigen, DRB1-4 beta chain [KO:K06752 ]
100343144 Orcu-DQA; SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752 ]
100351163 RLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752 ]
100351416 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
100341358 RLA class II histocompatibility antigen, DP beta chain [KO:K06752 ]
100352927 RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752 ]
100352672 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
100355948 RLA-DMB; histocompatibility antigen DM heterodimer light chain-like [KO:K06752 ]
100352415 RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like [KO:K06752 ]
100101577 TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476 ]
103347357 MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779 ]
Compound Reference Authors Fagarasan S, Honjo T
Title Intestinal IgA synthesis: regulation of front-line body defences.
Journal Reference Authors Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
Title The immune geography of IgA induction and function.
Journal Reference Authors Kunisawa J, Kiyono H
Title A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Journal Reference Authors Cerutti A, Rescigno M
Title The biology of intestinal immunoglobulin A responses.
Journal Reference Authors Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
Title Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
Journal Reference Authors Corthesy B
Title Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal Reference Authors Suzuki K, Fagarasan S
Title How host-bacterial interactions lead to IgA synthesis in the gut.
Journal Reference Authors Mora JR, von Andrian UH
Title Differentiation and homing of IgA-secreting cells.
Journal Reference Authors Suzuki K, Ha SA, Tsuji M, Fagarasan S
Title Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Journal Reference Authors Cerutti A
Title The regulation of IgA class switching.
Journal Related ocu04612 Antigen processing and presentation
ocu04660 T cell receptor signaling pathway
ocu04662 B cell receptor signaling pathway
ocu04670 Leukocyte transendothelial migration
KO pathway LinkDB All DBs
