KEGG   PATHWAY: ocu05161
Entry
ocu05161                    Pathway                                
Name
Hepatitis B - Oryctolagus cuniculus (rabbit)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
ocu05161  Hepatitis B
ocu05161

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100340334  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100009555  SLC10A1; hepatic sodium/bile acid cotransporter [KO:K14341]
100352301  LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375]
103345448  transforming growth factor beta-1 proprotein isoform X9 [KO:K13375]
100008645  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100009371  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
100358982  transforming growth factor beta-3 proprotein [KO:K13377]
100345812  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100344335  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
100346303  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100348489  cyclin-dependent kinase inhibitor 1 [KO:K06625]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100351345  E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100355500  early growth response protein 3 isoform X1 [KO:K12497]
100354135  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100340619  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100344073  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100354475  DNA damage-binding protein 1 [KO:K10610]
100352386  DNA damage-binding protein 2 [KO:K10140]
100348484  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100358299  14-3-3 protein beta/alpha [KO:K16197]
100008930  YWHAQ; 14-3-3 protein theta [KO:K16197]
100342694  14-3-3 protein zeta/delta [KO:K16197]
100344852  dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100355888  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100356401  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100357341  NF-kappa-B inhibitor alpha [KO:K04734]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100008993  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
103349397  apoptosis regulator Bcl-2 [KO:K02161]
100358587  bcl2-associated agonist of cell death [KO:K02158]
100008609  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100348477  caspase-8 [KO:K04398] [EC:3.4.22.61]
100101580  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100355991  BH3-interacting domain death agonist [KO:K04726]
100355675  apoptosis regulator BAX isoform X2 [KO:K02159]
103348383  apoptotic protease-activating factor 1 [KO:K02084]
100357840  cytochrome c-like [KO:K08738]
100355084  cytochrome c [KO:K08738]
100341050  cytochrome c-like [KO:K08738]
100354468  cytochrome c-like [KO:K08738]
100357329  cytochrome c [KO:K08738]
100341515  cytochrome c-like [KO:K08738]
100353673  cytochrome c, testis-specific isoform X1 [KO:K08738]
100351037  cytochrome c-like [KO:K08738]
100341175  cytochrome c [KO:K08738]
103347723  cytochrome c-like [KO:K08738]
100354724  cytochrome c-like [KO:K08738]
108178730  cytochrome c-like [KO:K08738]
108177422  cytochrome c-like [KO:K08738]
108175836  cytochrome c, somatic-like [KO:K08738]
127483320  cytochrome c-like [KO:K08738]
100101592  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103350677  LOW QUALITY PROTEIN: caspase-12 [KO:K04741] [EC:3.4.22.-]
103346801  baculoviral IAP repeat-containing protein 5 [KO:K08731]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100358389  cyclin-A1 isoform X1 [KO:K06627]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100352785  cyclin-A2-like [KO:K06627]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100134864  G1/S-specific cyclin-E1 [KO:K06626]
100134867  G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100357431  retinoblastoma-associated protein isoform X1 [KO:K06618]
100356957  transcription factor E2F1 [KO:K17454]
127489175  LOW QUALITY PROTEIN: transcription factor E2F1-like [KO:K17454]
100346379  transcription factor E2F2 [KO:K09389]
100353173  transcription factor E2F3 isoform X1 [KO:K06620]
100328760  ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100037719  PRKCB; protein kinase C beta type isoform I [KO:K19662] [EC:2.7.11.13]
100009102  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100352378  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100353824  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
100008859  nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
100347003  nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100352594  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100358134  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
127486194  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100344622  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100348778  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100343893  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
127488928  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
127491150  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
100344467  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100344146  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
127488925  signal transducer and activator of transcription 4-like [KO:K11222]
100348518  signal transducer and activator of transcription 5A [KO:K11223]
100348267  signal transducer and activator of transcription 5B [KO:K11224]
100344264  signal transducer and activator of transcription 6 [KO:K11225]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100342358  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100341599  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100342500  growth factor receptor-bound protein 2 [KO:K04364]
100356615  son of sevenless homolog 1 isoform X1 [KO:K03099]
100346391  son of sevenless homolog 2 isoform X1 [KO:K03099]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100008856  JUN; transcription factor Jun [KO:K04448]
100342294  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100339383  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100357489  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127493063  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
100009129  CXCL8; interleukin-8 precursor [KO:K10030]
100339381  proliferating cell nuclear antigen [KO:K04802]
100340437  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100351964  serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100338345  protein c-Fos [KO:K04379]
100340952  ETS domain-containing protein Elk-1 [KO:K04375]
100009578  TLR2; toll-like receptor 2 precursor [KO:K10159]
100340811  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100338708  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100009497  TLR4; toll-like receptor 4 [KO:K10160]
100341605  interleukin-1 receptor-associated kinase 4 isoform X4 [KO:K04733] [EC:2.7.11.1]
100354743  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100343190  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100358246  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
100342249  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100343571  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100339953  dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
100355230  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100350614  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
103346035  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100344161  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100341695  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103345313  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100345225  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100009024  TLR3; toll-like receptor 3 precursor [KO:K05401]
100347707  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:3.6.4.13]
100343560  interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
100356540  mitochondrial antiviral-signaling protein [KO:K12648]
100359083  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100354455  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100358771  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100348597  ATP-dependent RNA helicase DDX3X isoform X2 [KO:K11594] [EC:5.6.2.7]
103346571  interferon regulatory factor 3 isoform X1 [KO:K05411]
100353390  interferon alpha-21-like [KO:K05414]
100355669  interferon alpha-21-like [KO:K05414]
100355912  interferon alpha-5-like [KO:K05414]
100357708  interferon alpha-21-like isoform X2 [KO:K05414]
100354654  interferon alpha-21-like [KO:K05414]
100356419  interferon alpha-14-like [KO:K05414]
100357194  interferon alpha-21-like [KO:K05414]
100356678  interferon alpha-1/13 [KO:K05414]
100342931  interferon beta [KO:K05415]
100338604  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
ocu04010  MAPK signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04620  Toll-like receptor signaling pathway
ocu04622  RIG-I-like receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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