KEGG   PATHWAY: ocu05166
Entry
ocu05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Oryctolagus cuniculus (rabbit)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ocu05166  Human T-cell leukemia virus 1 infection
ocu05166

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100125988  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100345279  neuropilin-1 isoform X1 [KO:K06724]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100347280  transformation/transcription domain-associated protein isoform X1 [KO:K08874]
100340634  histone acetyltransferase KAT5 isoform X4 [KO:K11304] [EC:2.3.1.48]
100009036  G1/S-specific cyclin-D2 [KO:K10151]
100356927  integrin alpha-L isoform X1 [KO:K05718]
100339049  integrin beta-2 [KO:K06464]
100345640  intercellular adhesion molecule 1 isoform X2 [KO:K06490]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100009152  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100354375  talin-2 isoform X1 [KO:K06271]
100358920  talin-1 isoform X1 [KO:K06271]
100348546  ran-binding protein 3 isoform X6 [KO:K15304]
100352306  GTP-binding nuclear protein Ran [KO:K07936]
100357230  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran [KO:K07936]
100343451  exportin-1 isoform X2 [KO:K14290]
100009050  CALR; calreticulin precursor [KO:K08057]
100350417  calreticulin [KO:K08057]
100341645  calnexin [KO:K08054]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100356245  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100344533  calcineurin subunit B type 2 [KO:K06268]
100352378  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100353824  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
100008859  nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
100347003  nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
103346218  interleukin-2 receptor subunit beta [KO:K05069]
103351862  cytokine receptor common subunit gamma [KO:K05070]
100352594  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
127486194  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100348518  signal transducer and activator of transcription 5A [KO:K11223]
100348267  signal transducer and activator of transcription 5B [KO:K11224]
100302458  IL2; interleukin-2 isoform 1 precursor [KO:K05429]
100328967  RLA class I histocompatibility antigen, alpha chain 19-1 precursor [KO:K06751]
100338822  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100339821  LOW QUALITY PROTEIN: RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100348995  RLA class I histocompatibility antigen, alpha chain 11/11 isoform X16 [KO:K06751]
100349085  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100349247  HLA class I histocompatibility antigen, B alpha chain isoform X2 [KO:K06751]
100349757  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100354611  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X4 [KO:K06751]
100355380  patr class I histocompatibility antigen, A-2 alpha chain isoform X2 [KO:K06751]
100356371  RLA-A3; MHC class I antigen-like precursor [KO:K06751]
100350679  beta-2-microglobulin [KO:K08055]
103350044  farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100008751  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100349506  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
100009414  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100337764  ADP/ATP translocase 2 [KO:K05863]
100342972  ADP/ATP translocase 2-like [KO:K05863]
100346477  ADP/ATP translocase 4 isoform X1 [KO:K05863]
100348057  ADP/ATP translocase 2-like [KO:K05863]
100349768  ADP/ATP translocase 1 [KO:K05863]
100354802  ADP/ATP translocase 2-like [KO:K05863]
100356326  ADP/ATP translocase 2 [KO:K05863]
100009473  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100338710  translocator protein [KO:K05770]
100347991  translocator protein 2 [KO:K05770]
100338733  protein VAC14 homolog isoform X1 [KO:K15305]
100353385  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
100348625  mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
103347105  uncharacterized protein LOC103347105 [KO:K06679]
100354882  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100349688  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X6 [KO:K06637] [EC:2.7.11.1]
100352365  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
100348299  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
127486895  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2-like [KO:K03349]
100345196  cell division cycle protein 27 homolog isoform X2 [KO:K03350]
100350229  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100350286  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
127488420  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100359101  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100357348  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
100345665  cell division cycle protein 23 homolog [KO:K03355]
100342311  anaphase-promoting complex subunit 10 [KO:K03357]
100343351  anaphase-promoting complex subunit 11 [KO:K03358]
100357094  anaphase-promoting complex subunit 11 [KO:K03358]
100358835  anaphase-promoting complex subunit CDC26 [KO:K03359]
100352519  anaphase-promoting complex subunit 13 [KO:K12456]
100338921  anaphase-promoting complex subunit 15-like [KO:K25228]
100340312  anaphase-promoting complex subunit 15-like [KO:K25228]
100342681  anaphase-promoting complex subunit 15 isoform X3 [KO:K25228]
127483727  anaphase-promoting complex subunit 15-like [KO:K25228]
100342147  anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
100354874  cell division cycle protein 20 homolog [KO:K03363]
100356102  securin isoform X1 [KO:K06635]
100356870  securin [KO:K06635]
100356105  separin [KO:K02365] [EC:3.4.22.49]
100357416  G2/mitotic-specific cyclin-B2 [KO:K21770]
100351874  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100340625  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100009039  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100009038  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100348489  cyclin-dependent kinase inhibitor 1 [KO:K06625]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100352785  cyclin-A2-like [KO:K06627]
100358389  cyclin-A1 isoform X1 [KO:K06627]
100134864  G1/S-specific cyclin-E1 [KO:K06626]
100134867  G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100357431  retinoblastoma-associated protein isoform X1 [KO:K06618]
100356957  transcription factor E2F1 [KO:K17454]
127489175  LOW QUALITY PROTEIN: transcription factor E2F1-like [KO:K17454]
100346379  transcription factor E2F2 [KO:K09389]
100353173  transcription factor E2F3 isoform X1 [KO:K06620]
100349299  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100359062  serine/threonine-protein kinase ATR isoform X2 [KO:K06640] [EC:2.7.11.1]
100345729  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100339430  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100339253  disks large homolog 1 isoform X8 [KO:K12076]
100358716  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100346106  tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
100348484  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100344852  dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100008856  JUN; transcription factor Jun [KO:K04448]
100357971  matrilysin [KO:K01397] [EC:3.4.24.23]
100352905  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100344048  interleukin-1 receptor type 2 isoform X1 [KO:K04387]
108178285  uncharacterized protein LOC108178285 [KO:K10784]
100356153  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
100008616  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
100339529  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100352809  T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
100355340  T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
100355324  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100355888  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100356401  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100357341  NF-kappa-B inhibitor alpha [KO:K04734]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100338085  G protein pathway suppressor 2 isoform X4 [KO:K15307]
100346624  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
100349106  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
100350951  tumor necrosis factor receptor superfamily member 13C [KO:K05151]
100351032  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103346323  transcription factor RelB isoform X1 [KO:K09253]
100339928  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100340391  mRNA decay activator protein ZFP36 [KO:K15308]
100338113  interleukin-2 receptor subunit alpha [KO:K05068]
100358489  interleukin-2 receptor subunit alpha [KO:K05068]
100009017  IL15; interleukin-15 precursor [KO:K05433]
100358749  interleukin-15 receptor subunit alpha [KO:K05074]
100359262  interleukin-15 receptor subunit alpha [KO:K05074]
127487864  interleukin-15 receptor subunit alpha-like isoform X1 [KO:K05074]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100328720  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
100328931  LTA; lymphotoxin-alpha precursor [KO:K05468]
100008875  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100328700  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100345253  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
100008645  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100352301  LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375]
103345448  transforming growth factor beta-1 proprotein isoform X9 [KO:K13375]
100009371  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
100358982  transforming growth factor beta-3 proprotein [KO:K13377]
100345812  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100344335  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
100359137  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100346303  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100342294  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100343385  nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
100328929  RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
100341358  RLA class II histocompatibility antigen, DP beta chain isoform X1 [KO:K06752]
100343144  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100349408  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
100349667  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100350168  HLA class II histocompatibility antigen, DRB1 beta chain isoform X1 [KO:K06752]
100350656  RLA-DRB1; HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100351163  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100351416  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100352415  RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like precursor [KO:K06752]
100352672  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100352927  RLA class II histocompatibility antigen, DP alpha-1 chain isoform X2 [KO:K06752]
100355948  RLA-DMB; histocompatibility antigen DM heterodimer light chain-like precursor [KO:K06752]
127482571  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
100354695  serum response factor isoform X1 [KO:K04378]
100348164  ETS domain-containing protein Elk-4 [KO:K04376]
100340952  ETS domain-containing protein Elk-1 [KO:K04375]
103351779  LOW QUALITY PROTEIN: transcription factor PU.1 [KO:K09438]
100009373  ETS1; protein C-ets-1 [KO:K02678]
100350788  protein C-ets-2 [KO:K21932]
100343365  TATA-box-binding protein [KO:K03120]
100346981  TATA box-binding protein-like 1 isoform X2 [KO:K03120]
100349947  TATA box-binding protein-like 2 [KO:K03120]
100338345  protein c-Fos [KO:K04379]
100009491  early growth response protein 1 [KO:K09203]
100338208  fos-related antigen 1 [KO:K04502]
100351345  E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100339383  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100357489  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127493063  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
100358960  CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100338531  CREB-regulated transcription coactivator 3 isoform X3 [KO:K16334]
100340619  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100354135  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100346295  histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
100347774  histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
100353065  LOW QUALITY PROTEIN: histone acetyltransferase KAT2B-like [KO:K06062] [EC:2.3.1.48]
127485528  transcription factor E2-alpha isoform X1 [KO:K09063]
100348691  DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100349102  tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
100355675  apoptosis regulator BAX isoform X2 [KO:K02159]
100358955  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100343959  homeobox protein MSX-2 [KO:K09341]
103345887  homeobox protein MSX-1 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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Viruses 3:861-85 (2011)
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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PMID:23248621
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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Mol Aspects Med 31:350-8 (2010)
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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Pathogens 5:E8 (2016)
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
ocu03013  Nucleocytoplasmic transport
ocu04010  MAPK signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04350  TGF-beta signaling pathway
ocu04612  Antigen processing and presentation
ocu04660  T cell receptor signaling pathway
ocu04668  TNF signaling pathway
KO pathway
ko05166   
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