KEGG   PATHWAY: osa00010
Entry
osa00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Oryza sativa japonica (Japanese rice) (RefSeq)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
osa00010  Glycolysis / Gluconeogenesis
osa00010

Module
osa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:osa00010]
osa_M00002  Glycolysis, core module involving three-carbon compounds [PATH:osa00010]
osa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:osa00010]
osa_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:osa00010]
Other DBs
GO: 0006096 0006094
Organism
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
Gene
4343113  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
4326547  hexokinase-6 [KO:K00844] [EC:2.7.1.1]
4339420  hexokinase-2 [KO:K00844] [EC:2.7.1.1]
4342654  hexokinase-4, chloroplastic [KO:K00844] [EC:2.7.1.1]
4339361  hexokinase-5 [KO:K00844] [EC:2.7.1.1]
4326776  hexokinase-8 isoform X2 [KO:K00844] [EC:2.7.1.1]
4324666  hexokinase-9 isoform X1 [KO:K00844] [EC:2.7.1.1]
4326516  hexokinase-3 [KO:K00844] [EC:2.7.1.1]
4338010  hexokinase-7 [KO:K00844] [EC:2.7.1.1]
107275630  hexokinase-10 [KO:K00844] [EC:2.7.1.1]
4347311  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
4334290  glucose-6-phosphate isomerase, cytosolic A [KO:K01810] [EC:5.3.1.9]
4340677  glucose-6-phosphate isomerase, cytosolic B [KO:K01810] [EC:5.3.1.9]
4345842  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
4339369  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
4327301  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
4348582  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
4347060  ATP-dependent 6-phosphofructokinase 5, chloroplastic isoform X1 [KO:K00850] [EC:2.7.1.11]
4347383  ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
4336113  LOW QUALITY PROTEIN: ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:2.7.1.11]
4338034  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:2.7.1.11]
4340153  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
4327196  ATP-dependent 6-phosphofructokinase 6 isoform X1 [KO:K00850] [EC:2.7.1.11]
4345338  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
4330512  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
4340909  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
4340643  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
9271821  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha isoform X1 [KO:K00895] [EC:2.7.1.90]
4338912  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
4325071  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
4332364  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
4341770  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
4341496  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:4.1.2.13]
4326074  probable fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:4.1.2.13]
4349897  fructose-bisphosphate aldolase, chloroplastic [KO:K01623] [EC:4.1.2.13]
4344545  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:4.1.2.13]
4338737  fructose-bisphosphate aldolase cytoplasmic isozyme [KO:K01623] [EC:4.1.2.13]
4325027  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:4.1.2.13]
107277365  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:4.1.2.13]
4325211  triosephosphate isomerase, cytosolic [KO:K01803] [EC:5.3.1.1]
4347691  triosephosphate isomerase, chloroplastic [KO:K01803] [EC:5.3.1.1]
4327400  triosephosphate isomerase, cytosolic-like [KO:K01803] [EC:5.3.1.1]
4336216  glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic [KO:K00134] [EC:1.2.1.12]
4341782  glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic [KO:K00134] [EC:1.2.1.12]
4328446  glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic [KO:K00134] [EC:1.2.1.12]
4329892  glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic [KO:K00134] [EC:1.2.1.12]
4344564  glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic [KO:K00134] [EC:1.2.1.12]
4341792  phosphoglycerate kinase, cytosolic [KO:K00927] [EC:2.7.2.3]
4328435  phosphoglycerate kinase, cytosolic [KO:K00927] [EC:2.7.2.3]
9268592  phosphoglycerate kinase, chloroplastic [KO:K00927] [EC:2.7.2.3]
4339204  phosphoglycerate kinase, chloroplastic [KO:K00927] [EC:2.7.2.3]
4348728  phosphoglycerate kinase isoform X1 [KO:K00927] [EC:2.7.2.3]
4330747  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
9270925  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
4327493  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
4339133  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
4332728  2,3-bisphosphoglycerate-independent phosphoglycerate mutase isoform X1 [KO:K15633] [EC:5.4.2.12]
4340042  enolase 1 [KO:K01689] [EC:4.2.1.11]
4348176  enolase [KO:K01689] [EC:4.2.1.11]
4346906  enolase 1, chloroplastic [KO:K01689] [EC:4.2.1.11]
4332253  enolase-like [KO:K01689] [EC:4.2.1.11]
4332356  cytosolic enolase 3 [KO:K01689] [EC:4.2.1.11]
4337406  pyruvate kinase, cytosolic isozyme [KO:K00873] [EC:2.7.1.40]
4324263  pyruvate kinase, cytosolic isozyme [KO:K00873] [EC:2.7.1.40]
4349454  pyruvate kinase isozyme G, chloroplastic isoform X1 [KO:K00873] [EC:2.7.1.40]
4349774  pyruvate kinase 1, cytosolic [KO:K00873] [EC:2.7.1.40]
4333694  plastidial pyruvate kinase 1, chloroplastic [KO:K00873] [EC:2.7.1.40]
4351493  pyruvate kinase 2, cytosolic [KO:K00873] [EC:2.7.1.40]
4327173  plastidial pyruvate kinase 2 [KO:K00873] [EC:2.7.1.40]
4342564  pyruvate kinase isozyme A, chloroplastic [KO:K00873] [EC:2.7.1.40]
4350078  pyruvate kinase 1, cytosolic-like [KO:K00873] [EC:2.7.1.40]
4338750  pyruvate, phosphate dikinase 1, chloroplastic isoform X1 [KO:K01006] [EC:2.7.9.1]
4333181  pyruvate, phosphate dikinase 2 [KO:K01006] [EC:2.7.9.1]
4334968  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
4340640  pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial [KO:K00161] [EC:1.2.4.1]
4330673  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial [KO:K00161] [EC:1.2.4.1]
4346159  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
4352803  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic [KO:K00162] [EC:1.2.4.1]
4347531  pyruvate dehydrogenase E1 component subunit beta-2, mitochondrial [KO:K00162] [EC:1.2.4.1]
4333564  pyruvate dehydrogenase E1 component subunit beta-4, chloroplastic [KO:K00162] [EC:1.2.4.1]
4339859  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
4341113  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
4351678  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
4343003  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
4328010  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
4345640  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
4347022  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
4326980  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
4337862  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
4326849  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
4337881  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
4328012  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
4339856  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
4339066  pyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
4339068  pyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
4324066  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
4332519  pyruvate decarboxylase 2 [KO:K01568] [EC:4.1.1.1]
4344382  pyruvate decarboxylase 3 [KO:K01568] [EC:4.1.1.1]
4331130  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
4331893  alcohol dehydrogenase-like 7 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
4331894  alcohol dehydrogenase-like 2 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
4343942  alcohol dehydrogenase-like 2 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
4350055  alcohol dehydrogenase 2 [KO:K18857] [EC:1.1.1.1]
4350053  alcohol dehydrogenase 1 [KO:K18857] [EC:1.1.1.1]
4350054  alcohol dehydrogenase 2 [KO:K18857] [EC:1.1.1.1]
4348152  alcohol dehydrogenase-like 4 [KO:K00001] [EC:1.1.1.1]
4330090  alcohol dehydrogenase-like 6 [KO:K00001] [EC:1.1.1.1]
4327475  aldo-keto reductase family 4 member C10 isoform X1 [KO:K00002] [EC:1.1.1.2]
4327476  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
4338987  aldo-keto reductase family 4 member C10 isoform X1 [KO:K00002] [EC:1.1.1.2]
4339090  aldose reductase [KO:K00002] [EC:1.1.1.2]
4338986  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
9271397  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
4340725  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
4330612  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
4349966  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
4336538  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
4330146  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
4330149  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
9271186  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
4347172  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
4335745  acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal [KO:K01895] [EC:6.2.1.1]
4329518  acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal [KO:K01895] [EC:6.2.1.1]
4332592  acetate/butyrate--CoA ligase AAE7, peroxisomal [KO:K01913] [EC:6.2.1.1 6.2.1.2]
4332593  acetate/butyrate--CoA ligase AAE7, peroxisomal [KO:K01913] [EC:6.2.1.1 6.2.1.2]
4336037  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4329753  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4332976  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4348138  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4336039  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4346383  aldose 1-epimerase [KO:K01785] [EC:5.1.3.3]
4333895  phosphoglucomutase, cytoplasmic 2 [KO:K01835] [EC:5.4.2.2]
4348230  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
4328481  putative glucose-6-phosphate 1-epimerase isoform X1 [KO:K01792] [EC:5.1.3.15]
4327164  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
4337265  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
4346747  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
4339654  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
9268618  putative glucose-6-phosphate 1-epimerase isoform X1 [KO:K01792] [EC:5.1.3.15]
9269126  putative glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
4334577  multiple inositol polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
4345685  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
4332293  phosphoenolpyruvate carboxykinase [ATP] [KO:K01610] [EC:4.1.1.49]
4348268  phosphoenolpyruvate carboxykinase [ATP] [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
osa00020  Citrate cycle (TCA cycle)
osa00030  Pentose phosphate pathway
osa00500  Starch and sucrose metabolism
osa00620  Pyruvate metabolism
osa00640  Propanoate metabolism
osa00710  Carbon fixation in photosynthetic organisms
KO pathway
ko00010   
LinkDB

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