KEGG   PATHWAY: osa00260
Entry
osa00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Oryza sativa japonica (Japanese rice) (RefSeq)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
osa00260  Glycine, serine and threonine metabolism
osa00260

Module
osa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:osa00260]
osa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:osa00260]
osa_M00555  Betaine biosynthesis, choline => betaine [PATH:osa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
Gene
4326958  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
4334794  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
4342980  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
4346642  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
4345328  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
4334188  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
4331255  homoserine kinase [KO:K00872] [EC:2.7.1.39]
4339521  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
4325651  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
4336402  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
4338868  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
4324773  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
4350456  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
4334048  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
4352058  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
4345962  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
4327981  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
4334916  glyoxylate/hydroxypyruvate reductase HPR3 isoform X1 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
4334914  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
4334915  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
4334913  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
4330747  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
9270925  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
4327493  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
4339133  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
4332728  2,3-bisphosphoglycerate-independent phosphoglycerate mutase isoform X1 [KO:K15633] [EC:5.4.2.12]
4324401  D-glycerate 3-kinase, chloroplastic isoform X1 [KO:K15918] [EC:2.7.1.31]
4337230  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4341713  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4345710  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
9270715  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
4350964  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
4352281  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
4336153  copper methylamine oxidase [KO:K00276] [EC:1.4.3.21]
4340945  primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
4335335  LOW QUALITY PROTEIN: primary amine oxidase [KO:K00276] [EC:1.4.3.21]
107276105  copper methylamine oxidase-like [KO:K00276] [EC:1.4.3.21]
4343673  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
4340946  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
4325932  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
4341516  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
4337051  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
4326980  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
4337862  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
4326849  dihydrolipoyl dehydrogenase 1, chloroplastic [KO:K00382] [EC:1.8.1.4]
4337881  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
4341790  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
4349114  glycine cleavage system H protein, mitochondrial [KO:K02437]
4328441  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
9269154  uncharacterized protein LOC9269154 [KO:K02437]
4331779  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4332775  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4339095  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4342210  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
9272377  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
4345606  betaine aldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
4336081  betaine aldehyde dehydrogenase 1 [KO:K00130] [EC:1.2.1.8]
4347172  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
4327296  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107276062  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
4352447  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
4333898  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
4336624  serine racemase [KO:K12235] [EC:5.1.1.18]
4342571  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
4334425  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
4344612  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
4341584  tryptophan synthase beta chain 2 isoform X1 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
osa00010  Glycolysis / Gluconeogenesis
osa00020  Citrate cycle (TCA cycle)
osa00230  Purine metabolism
osa00250  Alanine, aspartate and glutamate metabolism
osa00270  Cysteine and methionine metabolism
osa00290  Valine, leucine and isoleucine biosynthesis
osa00300  Lysine biosynthesis
osa00330  Arginine and proline metabolism
osa00460  Cyanoamino acid metabolism
osa00470  D-Amino acid metabolism
osa00564  Glycerophospholipid metabolism
osa00600  Sphingolipid metabolism
osa00620  Pyruvate metabolism
osa00630  Glyoxylate and dicarboxylate metabolism
osa00640  Propanoate metabolism
osa00860  Porphyrin metabolism
osa00920  Sulfur metabolism
KO pathway
ko00260   
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