KEGG   PATHWAY: osa00480
Entry
osa00480                    Pathway                                
Name
Glutathione metabolism - Oryza sativa japonica (Japanese rice)
Class
Metabolism; Metabolism of other amino acids
Pathway map
osa00480  Glutathione metabolism
osa00480

Module
osa_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:osa00480]
Other DBs
GO: 0006749
Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
4324525  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
4324526  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
4336033  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
4329321  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
4335982  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
9270353  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
4337696  gcs; glutamate--cysteine ligase A, chloroplastic [KO:K01919] [EC:6.3.2.2]
4343165  GSH1-2; glutamate--cysteine ligase B, chloroplastic [KO:K01919] [EC:6.3.2.2]
9272324  glutathione synthetase, chloroplastic isoform X2 [KO:K21456] [EC:6.3.2.3]
4351008  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
4352123  putative leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
4346337  AAP-S; puromycin-sensitive aminopeptidase isoform 1 [KO:K01256] [EC:3.4.11.2]
4349207  GSTU6; probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4343183  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
4333870  uncharacterized protein [KO:K00799] [EC:2.5.1.18]
4332456  protein IN2-1 homolog A [KO:K00799] [EC:2.5.1.18]
4326828  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
4349192  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4325707  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
9269614  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4347319  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
4325704  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
4325710  B1039D07.2; probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
4325715  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
4331535  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
4332455  GSTZ5; protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
4350808  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
4325763  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4325764  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4325766  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4346877  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
4349185  uncharacterized protein [KO:K00799] [EC:2.5.1.18]
4349188  uncharacterized protein [KO:K00799] [EC:2.5.1.18]
4349190  uncharacterized protein [KO:K00799] [EC:2.5.1.18]
4349191  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
4349198  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349202  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349203  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4334347  GST1; probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
4333555  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
4326887  GST-II; probable glutathione S-transferase GSTF2 [KO:K00799] [EC:2.5.1.18]
4324574  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4325437  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4325709  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
4325712  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
4325765  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4325768  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
4326483  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
4331532  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
4331533  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
4331534  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
4342499  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4348461  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4348549  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
4348924  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
4349181  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349196  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349197  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349200  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349201  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349204  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349205  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349210  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4349270  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
9268428  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4325642  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4325643  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4333371  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
4338787  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
4349167  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
4337814  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
4349169  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
136353765  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
4337622  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
4340581  probable glutathione S-transferase DHAR2, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
4331112  GR; glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
4331719  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
4348623  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
4336353  isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
4339674  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
4327213  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
4324176  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
4339892  G6PGH1; phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) [KO:K00033] [EC:1.1.1.44 1.1.1.343]
4350528  6PGDH2; 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
4342988  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
4336209  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
4329889  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
4332659  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
4333103  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
4336627  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
4340341  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
4330235  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
4332876  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
4350287  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
4344045  R1C-Prx; 1-Cys peroxiredoxin A [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
4344046  1-Cys peroxiredoxin B [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
4347746  ornithine decarboxylase 1B, chloroplastic [KO:K01581] [EC:4.1.1.17]
4335010  ornithine decarboxylase 1A, chloroplastic-like [KO:K01581] [EC:4.1.1.17]
4342996  OsJ_23928; spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
4341195  spermine synthase [KO:K00797] [EC:2.5.1.16]
4328910  spermine synthase [KO:K00797] [EC:2.5.1.16]
4346247  APX4; probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
4344397  APX2; L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
4335202  APX3; probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
4332474  APX1; L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
4329643  APX8; probable L-ascorbate peroxidase 8, chloroplastic isoform 1 [KO:K00434] [EC:1.11.1.11]
4335896  APX7; probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
4351663  APX6; probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
4351664  APX5; probable L-ascorbate peroxidase 5, chloroplastic [KO:K00434] [EC:1.11.1.11]
9269342  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
4340258  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
4331059  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
4339981  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
9266846  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
osa00220  Arginine biosynthesis
osa00250  Alanine, aspartate and glutamate metabolism
osa00270  Cysteine and methionine metabolism
osa00430  Taurine and hypotaurine metabolism
osa00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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