KEGG   PATHWAY: osa03430
osa03430                    Pathway                                
Mismatch repair - Oryza sativa japonica (Japanese rice) (RefSeq)
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
osa03430  Mismatch repair

Other DBs
GO: 0006298
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
4337429  endonuclease MutS2 [KO:K07456]
4326564  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
4329835  DNA mismatch repair protein PMS1 isoform X1 [KO:K10858]
4325393  DNA mismatch repair protein MLH1 isoform X1 [KO:K08734]
4347016  DNA mismatch repair protein MSH6 [KO:K08737]
4325353  DNA mismatch repair protein MSH7 [KO:K08737]
4338271  DNA mismatch repair protein MSH2 [KO:K08735]
4337442  DNA mismatch repair protein MSH3 isoform X1 [KO:K08736]
4350754  replication factor C subunit 1 [KO:K10754]
4351654  replication factor C subunit 2 [KO:K10755]
4336704  replication factor C subunit 4 [KO:K10755]
4330895  replication factor C subunit 3 [KO:K10756]
4334389  replication factor C subunit 5 [KO:K10756]
4349480  replication factor C subunit 3 [KO:K10756]
4331062  proliferating cell nuclear antigen [KO:K04802]
4327899  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
4337594  replication protein A 70 kDa DNA-binding subunit C [KO:K07466]
4330902  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
4332052  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
4331236  replication protein A 32 kDa subunit A [KO:K10739]
4330068  replication protein A 32 kDa subunit B isoform X2 [KO:K10739]
4327706  replication protein A 14 kDa subunit [KO:K10740]
4349968  DNA polymerase delta catalytic subunit [KO:K02327] [EC:]
4331489  DNA polymerase delta small subunit [KO:K02328]
4327080  protein IWS1 homolog A [KO:K03504]
4347604  uncharacterized protein LOC4347604 [KO:K03505]
4344737  DNA polymerase delta subunit 4 [KO:K03505]
4348965  DNA ligase 1 [KO:K10747] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair]
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

DBGET integrated database retrieval system