KEGG   PATHWAY: osa03440
osa03440                    Pathway                                
Homologous recombination - Oryza sativa japonica (Japanese rice) (RefSeq)
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
Pathway map
osa03440  Homologous recombination

Other DBs
GO: 0000724
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
4326564  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
4325041  DNA repair protein recA homolog 3, mitochondrial [KO:K03553]
4333537  DNA repair protein recA homolog 1, chloroplastic [KO:K03553]
4350329  protein RecA [KO:K03553]
4344789  DNA polymerase I A, chloroplastic [KO:K02335] [EC:]
4344791  DNA polymerase I B, mitochondrial isoform X1 [KO:K02335] [EC:]
4337150  DNA polymerase I A, chloroplastic-like isoform X1 [KO:K02335] [EC:]
4330491  ATP-dependent DNA helicase homolog RECG, chloroplastic isoform X1 [KO:K03655] [EC:]
4329409  DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
4337137  double-strand break repair protein MRE11 [KO:K10865]
4348951  nijmegen breakage syndrome 1 protein isoform X1 [KO:K10867]
4326151  serine/threonine-protein kinase ATM isoform X1 [KO:K04728] [EC:]
4339293  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X1 [KO:K10683]
4336384  BRCA1-associated RING domain protein 1 isoform X1 [KO:K10683]
107276010  BRCA1-associated RING domain protein 1-like [KO:K10683]
4347791  Fanconi anemia group J protein homolog isoform X1 [KO:K15362] [EC:]
4332589  uncharacterized protein LOC4332589 [KO:K10728]
4344363  LOW QUALITY PROTEIN: BRCT domain-containing protein At4g02110 [KO:K10728]
4349978  DNA topoisomerase 2-binding protein 1-A isoform X1 [KO:K10728]
4340143  uncharacterized protein LOC4340143 [KO:K20776]
4342073  BRCA1-A complex subunit BRE [KO:K12173]
4339481  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
4324417  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B isoform X1 [KO:K08775]
4325173  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
4327264  probable 26S proteasome complex subunit sem1-1 [KO:K10881]
4330902  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
4338202  uncharacterized protein At4g28440 [KO:K07466]
4326359  uncharacterized protein At4g28440 [KO:K07466]
4337594  replication protein A 70 kDa DNA-binding subunit C [KO:K07466]
4325130  uncharacterized protein At4g28440 [KO:K07466]
4332052  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
9267714  uncharacterized protein At4g28440 [KO:K07466]
4327373  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
4334834  replication protein A 70 kDa DNA-binding subunit B isoform X1 [KO:K07466]
4348221  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
9266301  uncharacterized protein LOC9266301 [KO:K07466]
4342616  replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
107280671  replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
9272338  replication protein A 70 kDa DNA-binding subunit [KO:K07466]
107279348  replication protein A 70 kDa DNA-binding subunit D-like isoform X1 [KO:K07466]
4345008  uncharacterized protein LOC4345008 isoform X1 [KO:K07466]
4351558  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
9266862  replication protein A 70 kDa DNA-binding subunit D isoform X1 [KO:K07466]
4331236  replication protein A 32 kDa subunit A [KO:K10739]
4330068  replication protein A 32 kDa subunit B isoform X2 [KO:K10739]
4327706  replication protein A 14 kDa subunit [KO:K10740]
4350923  DNA repair protein RAD51 homolog A [KO:K04482]
4352257  DNA repair protein RAD51 homolog B [KO:K04482]
4337655  DNA repair protein RAD51 homolog 2 [KO:K10869]
4323853  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
4346376  DNA repair protein RAD51 homolog 4 isoform X1 [KO:K10871]
4329686  DNA repair protein XRCC3 homolog [KO:K10880]
4330819  DNA repair and recombination protein RAD54 [KO:K10875] [EC:5.6.2.-]
4338690  SNF2 domain-containing protein CLASSY 4 [KO:K10875] [EC:5.6.2.-]
4343066  protein CHROMATIN REMODELING 35 isoform X1 [KO:K10875] [EC:5.6.2.-]
4340671  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
9267584  protein CHROMATIN REMODELING 35 [KO:K10875] [EC:5.6.2.-]
107277028  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
4344376  SNF2 domain-containing protein CLASSY 1 [KO:K10875] [EC:5.6.2.-]
107277180  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
4349968  DNA polymerase delta catalytic subunit [KO:K02327] [EC:]
4331489  DNA polymerase delta small subunit [KO:K02328]
4327080  protein IWS1 homolog A [KO:K03504]
4347604  uncharacterized protein LOC4347604 [KO:K03505]
4344737  DNA polymerase delta subunit 4 [KO:K03505]
4330923  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:]
4335888  ATP-dependent DNA helicase Q-like 4A isoform X1 [KO:K10901] [EC:]
4347482  DNA topoisomerase 3-beta [KO:K03165] [EC:]
9269718  DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:]
4325837  crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
4337213  crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators]
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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