Entry
Name
Protein processing in endoplasmic reticulum - Oryza sativa japonica (Japanese rice)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
osa04141 Protein processing in endoplasmic reticulum
Ortholog table
Other DBs
Organism
Oryza sativa japonica (Japanese rice) [GN:
osa ]
Gene
4345097 CpSecY; preprotein translocase subunit SECY, chloroplastic [KO:K10956 ]
4328492 OsJ_05608; protein transport protein Sec61 subunit gamma [KO:K07342 ]
4341707 protein transport protein Sec61 subunit gamma-like [KO:K07342 ]
4338348 OsJ_17960; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A precursor [KO:K12666 ]
107275757 OsJ_16761; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B precursor [KO:K12666 ]
4324876 RPN-II; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor [KO:K12667 ]
4335701 DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668 ]
4342702 OST48; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor [KO:K12670 ]
4337389 OsJ_16609; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151 ] [EC:2.4.99.18 ]
4339345 OsJ_19234; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151 ] [EC:2.4.99.18 ]
4333265 OST3; probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 precursor [KO:K19478 ]
4328607 DJC16; DnaJ protein P58IPK homolog A precursor [KO:K09523 ]
4327812 P58B; DnaJ protein P58IPK homolog B precursor [KO:K09523 ]
4324264 OsJ_01291; glucosidase 2 subunit beta isoform 1 precursor [KO:K08288 ]
4330236 UDP-glucose:glycoprotein glucosyltransferase [KO:K11718 ] [EC:2.4.1.-]
4337858 OsJ_17181; protein disulfide isomerase-like 2-1 isoform 1 precursor [KO:K09584 ] [EC:5.3.4.1 ]
4334011 endoplasmic reticulum oxidoreductin-1 [KO:K10950 ] [EC:1.8.4.-]
4328514 ubiquitin fusion degradation protein 1 homolog [KO:K14016 ]
4351875 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
4338354 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
4334611 hsp70 nucleotide exchange factor fes1 isoform X1 [KO:K09562 ]
4347551 hsp70 nucleotide exchange factor FES1 isoform X2 [KO:K09562 ]
4328736 HSP19.0; 19.0 kDa class II heat shock protein [KO:K13993 ]
4350180 HSP21.9; 21.9 kDa heat shock protein precursor [KO:K13993 ]
4335956 HSP23.2; 23.2 kDa heat shock protein precursor [KO:K13993 ]
4332237 HSP26.7; 26.7 kDa heat shock protein, chloroplastic [KO:K13993 ]
4330933 HSP18.6; 18.6 kDa class III heat shock protein [KO:K13993 ]
4330786 HSP24.1; 24.1 kDa heat shock protein, mitochondrial isoform 1 [KO:K13993 ]
4340508 HSP26.2; 26.2 kDa heat shock protein, mitochondrial [KO:K13993 ]
4325698 HSP16.9B; 16.9 kDa class I heat shock protein 2 [KO:K13993 ]
4325697 HSP16.9A; 16.9 kDa class I heat shock protein 1 [KO:K13993 ]
4325696 HSP16.9C; 16.9 kDa class I heat shock protein 3 [KO:K13993 ]
4340661 HSP16.0; 16.0 kDa heat shock protein, peroxisomal [KO:K13993 ]
4325342 HSP18.0; 18.0 kDa class II heat shock protein [KO:K13993 ]
4328405 OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719 ] [EC:3.1.2.-]
4347014 OsJ_29306; probable ubiquitin receptor RAD23 isoform 1 [KO:K10839 ]
4331510 ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523 ]
4332538 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
4344379 eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237 ]
4343198 IRE1; serine/threonine-protein kinase/endoribonuclease IRE1 precursor [KO:K08852 ] [EC:2.7.11.1 3.1.26.-]
4332310 HRD3; eRAD-associated E3 ubiquitin-protein ligase component HRD3 precursor [KO:K14026 ]
4346585 probable disease resistance protein At1g61300 isoform X1 [KO:K03094 ]
Compound
Reference
Authors
Naidoo N
Title
ER and aging-Protein folding and the ER stress response.
Journal
Reference
Authors
Malhotra JD, Kaufman RJ
Title
The endoplasmic reticulum and the unfolded protein response.
Journal
Reference
Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Title
Protein quality control in the ER: the recognition of misfolded proteins.
Journal
Reference
Authors
Stolz A, Wolf DH
Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Journal
Reference
Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
Journal
Related pathway
KO pathway
LinkDB
All DBs