KEGG   PATHWAY: osa04141
Entry
osa04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Oryza sativa japonica (Japanese rice)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
osa04141  Protein processing in endoplasmic reticulum
osa04141

Other DBs
GO: 0030433 0034976
Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
4346811  uncharacterized protein [KO:K10956]
4332042  uncharacterized protein [KO:K10956]
4345097  CpSecY; preprotein translocase subunit SECY, chloroplastic [KO:K10956]
4346809  uncharacterized protein [KO:K10956]
4347548  uncharacterized protein [KO:K10956]
107276128  uncharacterized protein [KO:K10956]
112937349  uncharacterized protein [KO:K10956]
4327929  protein transport protein Sec61 subunit beta [KO:K09481]
9271333  protein transport protein Sec61 subunit beta [KO:K09481]
9266625  protein transport protein Sec61 subunit beta [KO:K09481]
9269540  protein transport protein Sec61 subunit beta [KO:K09481]
4328492  OsJ_05608; protein transport protein Sec61 subunit gamma [KO:K07342]
4341707  protein transport protein Sec61 subunit gamma-like [KO:K07342]
4329219  uncharacterized protein [KO:K12275]
4335435  DJC43; DnaJ protein ERDJ2 [KO:K09540]
4338348  OsJ_17960; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A precursor [KO:K12666]
107275757  OsJ_16761; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B precursor [KO:K12666]
4324876  RPN-II; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor [KO:K12667]
4335701  DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
4342702  OST48; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor [KO:K12670]
4337389  OsJ_16609; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
4339345  OsJ_19234; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
4333265  OST3; probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 precursor [KO:K19478]
4329143  uncharacterized protein [KO:K26501]
4341334  uncharacterized protein [KO:K26502]
4327748  alpha-glucosidase 2 isoform X1 [KO:K01228] [EC:3.2.1.106]
4330492  heat shock 70 kDa protein 17 [KO:K09486]
4328075  BIP1; heat shock 70 kDa protein BIP1 precursor [KO:K09490] [EC:3.6.4.10]
4339788  heat shock 70 kDa protein BIP4-like [KO:K09490] [EC:3.6.4.10]
4338866  BIP4; heat shock 70 kDa protein BIP4 precursor [KO:K09490] [EC:3.6.4.10]
4333877  BIP2; heat shock 70 kDa protein BIP2 precursor [KO:K09490] [EC:3.6.4.10]
4340470  luminal-binding protein 4 [KO:K09490] [EC:3.6.4.10]
9266859  uncharacterized protein [KO:K09490] [EC:3.6.4.10]
107275251  heat shock 70 kDa protein BIP3-like [KO:K09490] [EC:3.6.4.10]
4337860  DJB6; DnaJ protein ERDJ3B precursor [KO:K09517]
4328607  DJC16; DnaJ protein P58IPK homolog A precursor [KO:K09523]
4327812  P58B; DnaJ protein P58IPK homolog B precursor [KO:K09523]
4342077  endoplasmin homolog [KO:K09487]
4345893  heat shock protein 90-5, chloroplastic [KO:K09487]
4352339  heat shock protein 90-6, mitochondrial [KO:K09487]
4347356  heat shock protein 90-5, chloroplastic [KO:K09487]
4332068  OsJ_09923; probable glucan 1,3-alpha-glucosidase precursor [KO:K05546] [EC:3.2.1.207]
4324264  OsJ_01291; glucosidase 2 subunit beta isoform 1 precursor [KO:K08288]
4335732  calnexin homolog [KO:K08054]
4342826  CRO1; calreticulin precursor [KO:K08057]
4334675  calreticulin-like [KO:K08057]
4334509  calreticulin-2 isoform X2 [KO:K08057]
4339262  calreticulin-3 [KO:K08057]
9267167  calreticulin-3 [KO:K08057]
4336917  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
4338088  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
4350905  SEC12-like protein 2 [KO:K14003]
4342601  SEC12-like protein 1 [KO:K14003]
9270427  SEC12-like protein 1 isoform X1 [KO:K14003]
4326797  small COPII coat GTPase SAR1A [KO:K07953] [EC:3.6.5.-]
4327708  GBP; GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
4352510  small COPII coat GTPase SAR1A [KO:K07953] [EC:3.6.5.-]
4340541  GTP-binding protein SAR2 [KO:K07953] [EC:3.6.5.-]
4328228  protein transport protein SEC13 homolog B [KO:K14004]
4342827  protein transport protein SEC13 homolog B [KO:K14004]
4334673  protein transport protein SEC13 homolog B [KO:K14004]
4344154  protein transport protein SEC31 homolog B [KO:K14005]
4345819  protein transport protein SEC23 C [KO:K14006]
4350403  protein transport protein SEC23 E [KO:K14006]
4334068  protein transport protein SEC23 G isoform X1 [KO:K14006]
4347283  protein transport protein SEC23 C [KO:K14006]
4334998  protein transport protein SEC24 A [KO:K14007]
4352115  protein transport protein SEC24 B [KO:K14007]
4330236  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
4330685  alpha-mannosidase I MNS5 [KO:K10084]
4327149  alpha-mannosidase I MNS4 [KO:K10085]
4327971  OsJ_04977; protein disulfide isomerase-like 1-4 precursor [KO:K09580] [EC:5.3.4.1]
4329652  OsPDIL1-3; protein disulfide isomerase-like 1-3 [KO:K09580] [EC:5.3.4.1]
4335906  OsPDIL1-2; protein disulfide isomerase-like 1-2 precursor [KO:K09580] [EC:5.3.4.1]
4350002  OsJ_33281; protein disulfide isomerase-like 1-1 precursor [KO:K09580] [EC:5.3.4.1]
4340223  OsPDIL1-5; protein disulfide isomerase-like 1-5 precursor [KO:K09580] [EC:5.3.4.1]
4329624  OsJ_07093; protein disulfide isomerase-like 5-3 precursor [KO:K09580] [EC:5.3.4.1]
4335881  OsPDIL5-2; protein disulfide isomerase-like 5-2 precursor [KO:K09580] [EC:5.3.4.1]
4347226  OsPDIL2-3; protein disulfide isomerase-like 2-3 precursor [KO:K09584] [EC:5.3.4.1]
4326806  OsJ_01619; protein disulfide isomerase-like 2-2 precursor [KO:K09584] [EC:5.3.4.1]
4337858  OsJ_17181; protein disulfide isomerase-like 2-1 isoform 1 precursor [KO:K09584] [EC:5.3.4.1]
4334011  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
9268424  OS9; protein OS-9 homolog precursor [KO:K10088]
4342072  translocon-associated protein subunit alpha [KO:K13249]
4326440  uncharacterized protein isoform X2 [KO:K13250]
4337538  uncharacterized protein isoform X3 [KO:K13250]
4329170  uncharacterized protein [KO:K14009]
4341009  uncharacterized protein [KO:K14009]
4338268  uncharacterized protein [KO:K14009]
4334781  uncharacterized protein [KO:K14009]
9270888  uncharacterized protein [KO:K14009]
4334809  DER2; derlin-2 [KO:K13989]
4338013  B1007D10.4; derlin-1 [KO:K13989]
4350306  plant UBX domain-containing protein 11 [KO:K24348]
4347001  plant UBX domain-containing protein 2 [KO:K14011]
4341597  plant UBX domain-containing protein 4 [KO:K14012]
4336083  plant UBX domain-containing protein 4 [KO:K14012]
4331645  cell division cycle protein 48 homolog [KO:K13525]
4348731  cell division control protein 48 homolog E [KO:K13525]
4325451  nPL4-like protein [KO:K14015]
4328514  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
4336742  uncharacterized protein [KO:K14016]
107276927  uncharacterized protein [KO:K14016]
4339012  heat shock 70 kDa protein 4 [KO:K03283]
4351208  heat shock cognate 70 kDa protein 2 [KO:K03283]
4351875  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
4327388  heat shock 70 kDa protein 4 [KO:K03283]
4332413  heat shock cognate 70 kDa protein 2 [KO:K03283]
4332420  heat shock cognate 70 kDa protein [KO:K03283]
4334598  heat shock cognate 70 kDa protein 2 [KO:K03283]
4332416  heat shock cognate 70 kDa protein [KO:K03283]
9271426  heat shock cognate 70 kDa protein [KO:K03283]
4349971  heat shock cognate 70 kDa protein [KO:K03283]
4338354  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
107275844  heat shock cognate 70 kDa protein [KO:K03283]
107279546  heat shock cognate 70 kDa protein-like [KO:K03283]
4334359  DnaJ protein homolog [KO:K09503]
4330201  chaperone protein DnaJ A6-like [KO:K09503]
4333580  DnaJ protein homolog [KO:K09503]
4336584  DJA6; chaperone protein DnaJ A6 [KO:K09503]
136354612  DnaJ protein homolog [KO:K09503]
4324566  chaperone protein DnaJ 49 [KO:K09518]
4338551  chaperone protein DnaJ 49 [KO:K09518]
4347402  HSP81-2; heat shock protein 81-2 [KO:K04079]
4345951  HSP81-1; heat shock protein 81-1 [KO:K04079]
4347405  HSP81-3; heat shock protein 81-3 [KO:K04079]
9267802  heat shock protein 81-3-like [KO:K04079]
9267997  heat shock protein 82 [KO:K04079]
136351808  heat shock protein 81-3 [KO:K04079]
4334611  hsp70 nucleotide exchange factor fes1 isoform X1 [KO:K09562]
4332391  hsp70 nucleotide exchange factor FES1 [KO:K09562]
4347551  hsp70 nucleotide exchange factor FES1 isoform X2 [KO:K09562]
4332360  HSP17.4; 17.4 kDa class I heat shock protein [KO:K13993]
4328736  HSP19.0; 19.0 kDa class II heat shock protein [KO:K13993]
4350180  HSP21.9; 21.9 kDa heat shock protein precursor [KO:K13993]
4325695  HSP17.9B; 17.9 kDa heat shock protein 2 [KO:K13993]
4335956  HSP23.2; 23.2 kDa heat shock protein precursor [KO:K13993]
4328171  HSP18.9; 18.9 kDa heat shock protein [KO:K13993]
4330496  HSP17.8; 17.8 kDa heat shock protein [KO:K13993]
4332237  HSP26.7; 26.7 kDa heat shock protein, chloroplastic [KO:K13993]
4330933  HSP18.6; 18.6 kDa class III heat shock protein [KO:K13993]
4343386  HSP18.8; 18.8 kDa class V heat shock protein [KO:K13993]
4330786  HSP24.1; 24.1 kDa heat shock protein, mitochondrial isoform 1 [KO:K13993]
4340508  HSP26.2; 26.2 kDa heat shock protein, mitochondrial [KO:K13993]
4325698  HSP16.9B; 16.9 kDa class I heat shock protein 2 [KO:K13993]
4325697  HSP16.9A; 16.9 kDa class I heat shock protein 1 [KO:K13993]
4325696  HSP16.9C; 16.9 kDa class I heat shock protein 3 [KO:K13993]
4332361  HSP18.1; 18.1 kDa class I heat shock protein [KO:K13993]
4332357  hsp17.9; 17.9 kDa class I heat shock protein [KO:K13993]
4332363  HSP17.7; 17.7 kDa class I heat shock protein [KO:K13993]
4325694  HSP16.6; 16.6 kDa heat shock protein [KO:K13993]
4340661  HSP16.0; 16.0 kDa heat shock protein, peroxisomal [KO:K13993]
107278626  23.6 kDa heat shock protein, mitochondrial [KO:K13993]
4325342  HSP18.0; 18.0 kDa class II heat shock protein [KO:K13993]
9271911  small heat shock protein, chloroplastic [KO:K13993]
4328405  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
4342300  uncharacterized protein [KO:K14018]
4328500  ubiquitin receptor RAD23b [KO:K10839]
4345632  probable ubiquitin receptor RAD23 isoform X1 [KO:K10839]
4347014  OsJ_29306; probable ubiquitin receptor RAD23 isoform 1 [KO:K10839]
4340699  ubiquitin receptor RAD23d [KO:K10839]
4349264  ubiquitin domain-containing protein DSK2a [KO:K04523]
4331510  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
4343301  PNG1; peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
4324808  putative ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
4333165  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
4332538  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
4344379  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
4340224  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
4343198  IRE1; serine/threonine-protein kinase/endoribonuclease IRE1 precursor [KO:K08852] [EC:2.7.11.1 3.1.26.-]
9272448  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
4341618  P0458E02.2; probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
4332614  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
4340379  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
4339013  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
4327386  P0408C03.9; ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
4340826  HRD1; eRAD-associated E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
4339072  uncharacterized protein [KO:K10666] [EC:2.3.2.27]
4336483  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
4325492  uncharacterized protein [KO:K10666] [EC:2.3.2.27]
4352888  uncharacterized protein [KO:K10666] [EC:2.3.2.27]
4333714  uncharacterized protein [KO:K10666] [EC:2.3.2.27]
136351055  uncharacterized protein [KO:K10666] [EC:2.3.2.27]
4332310  HRD3; eRAD-associated E3 ubiquitin-protein ligase component HRD3 precursor [KO:K14026]
4343241  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
4337553  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
4344499  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
4328114  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
4327450  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K06689] [EC:2.3.2.23]
4337331  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
4346639  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
4327162  OsJ_02884; ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
4328940  OsJ_06152; ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
4341133  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
4327451  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
136356049  ubiquitin-conjugating enzyme E2-17 kDa-like isoform X1 [KO:K06689] [EC:2.3.2.23]
136356056  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
4326152  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
4330476  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
4325735  cullin-1-like [KO:K03347]
4337820  cullin-1-like isoform X1 [KO:K03347]
4325736  cullin-1 [KO:K03347]
4347721  SKP1-like protein 20 [KO:K03094]
4345419  SKP1-like protein 5 [KO:K03094]
4346586  SKP1-like protein 5 [KO:K03094]
4343963  SKP1-like protein 11 [KO:K03094]
4346592  SKP1-like protein 4 [KO:K03094]
4343000  SKP1-like protein 1 [KO:K03094]
4348713  SKP1-like protein 11 [KO:K03094]
4343962  SKP1-like protein 14 [KO:K03094]
4339908  SKP1-like protein 5 [KO:K03094]
4346585  probable disease resistance protein At1g61300 isoform X1 [KO:K03094]
9270098  OsJ_33809; SKP1-like protein 1 [KO:K03094]
107275366  SKP1-like protein 5 [KO:K03094]
107275430  SKP1-like protein 1A [KO:K03094]
107275462  SKP1-like protein 5 [KO:K03094]
107275506  SKP1-like protein 5 [KO:K03094]
107275529  SKP1-like protein 5 [KO:K03094]
107275695  SKP1-like protein 5 [KO:K03094]
107275970  SKP1-like protein 5 [KO:K03094]
107276398  SKP1-like protein 11 [KO:K03094]
107277355  SKP1-like protein 11 [KO:K03094]
107278210  SKP1-like protein 13 [KO:K03094]
107278737  SKP1-like protein 4 [KO:K03094]
107281645  SKP1-like protein 11 [KO:K03094]
107282017  SKP1-like protein 5 [KO:K03094]
136351860  SKP1-like protein 5 [KO:K03094]
107277129  SKP1-like protein 5 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
osa00510  N-Glycan biosynthesis
osa03050  Proteasome
osa03060  Protein export
KO pathway
ko04141   
LinkDB

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