KEGG   PATHWAY: osa04148
Entry
osa04148                    Pathway                                
Name
Efferocytosis - Oryza sativa japonica (Japanese rice)
Class
Cellular Processes; Transport and catabolism
Pathway map
osa04148  Efferocytosis
osa04148

Organism
Oryza sativa japonica (Japanese rice) [GN:osa]
Gene
4327845  sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
4343607  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
4350264  MPK15; mitogen-activated protein kinase 15 [KO:K04371] [EC:2.7.11.24]
4324023  MAPKK1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
4337816  PWWP domain-containing protein 1 isoform X1 [KO:K17398] [EC:2.1.1.37]
4333998  calcium-transporting ATPase 3, endoplasmic reticulum-type isoform X1 [KO:K05853] [EC:7.2.2.10]
4340847  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
4330549  protein-tyrosine-phosphatase IBR5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
4324268  phospholipid-transporting ATPase 1 [KO:K14802] [EC:7.6.2.1]
4348609  phospholipid-transporting ATPase 3 isoform X1 [KO:K14802] [EC:7.6.2.1]
4332708  phospholipid-transporting ATPase 1 [KO:K14802] [EC:7.6.2.1]
4332752  phospholipid-transporting ATPase 1 isoform X1 [KO:K14802] [EC:7.6.2.1]
4331429  ALA-interacting subunit 5 [KO:K26935]
4334345  putative ALA-interacting subunit 2 [KO:K26935]
4328458  ALA-interacting subunit 1 [KO:K26935]
4341775  ALA-interacting subunit 3 [KO:K26935]
4339407  ALA-interacting subunit 1 [KO:K26935]
4325879  OsRac1; rac-like GTP-binding protein 1 [KO:K04392]
4330693  OsJ_08342; rac-like GTP-binding protein 3 [KO:K04392]
4340590  OsJ_20720; rac-like GTP-binding protein 4 isoform 1 [KO:K04392]
4339304  OsJ_19185; rac-like GTP-binding protein 2 [KO:K04392]
4329132  OsJ_06426; rac-like GTP-binding protein 7 [KO:K04392]
4331272  OsJ_09018; rac-like GTP-binding protein 5 [KO:K04392]
4328116  OsJ_05161; rac-like GTP-binding protein 6 [KO:K04392]
4342826  CRO1; calreticulin precursor [KO:K08057]
4334675  calreticulin-like [KO:K08057]
4334509  calreticulin-2 isoform X2 [KO:K08057]
4339262  calreticulin-3 [KO:K08057]
9267167  calreticulin-3 [KO:K08057]
4352862  GLUP4; ras-related protein Rab5A [KO:K07889]
4337547  vacuolar sorting protein 3 isoform X1 [KO:K20177]
4328144  uncharacterized protein [KO:K20178]
4335642  vacuolar protein-sorting-associated protein 11 homolog isoform X1 [KO:K20179]
4326864  protein VACUOLELESS1 [KO:K20180]
4344807  vacuolar sorting protein 18 [KO:K20181]
4335201  vacuolar protein-sorting-associated protein 33 homolog isoform X1 [KO:K20182]
4333909  vacuolar sorting protein 39 isoform X1 [KO:K20183]
4335134  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
4339322  ras-related protein Rab7 [KO:K07897]
4325946  ras-related protein Rab7 [KO:K07897]
4339450  ras-related protein Rab7 [KO:K07897]
4327180  ras-related protein Rab7 [KO:K07897]
4324377  vacuolar lysine transporter YPQ1 isoform X1 [KO:K23678]
4334912  ARG1; arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
4347746  ornithine decarboxylase 1B, chloroplastic [KO:K01581] [EC:4.1.1.17]
4335010  ornithine decarboxylase 1A, chloroplastic-like [KO:K01581] [EC:4.1.1.17]
4335710  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4329497  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4346369  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
107275667  triacylglycerol lipase 2 [KO:K01052] [EC:3.1.1.13]
4346120  triacylglycerol lipase 2 [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
osa00010  Glycolysis / Gluconeogenesis
osa04145  Phagosome
KO pathway
ko04148   
LinkDB

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