KEGG   PATHWAY: pdam04137
Entry
pdam04137                   Pathway                                

Name
Mitophagy - animal - Pocillopora damicornis (lace coral)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
pdam04137  Mitophagy - animal
pdam04137

Other DBs
GO: 0000422
Organism
Pocillopora damicornis (lace coral) [GN:pdam]
Gene
113670326  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
113664928  stress-activated protein kinase JNK-like isoform X1 [KO:K04440] [EC:2.7.11.24]
113681226  transcription factor jun-D-like [KO:K04448]
113683358  transcription factor AP-1-like [KO:K04448]
113665429  transcription factor AP-1-like [KO:K04448]
113679963  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
113682110  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
113686101  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113669304  ubiquitin-40S ribosomal protein S27a [KO:K02977]
113668222  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
113673195  LOW QUALITY PROTEIN: transmembrane GTPase fzo-like [KO:K21356] [EC:3.6.5.-]
113673196  LOW QUALITY PROTEIN: uncharacterized protein LOC113673196 [KO:K21356] [EC:3.6.5.-]
113681238  mitofusin-2-like [KO:K06030] [EC:3.6.5.-]
113671437  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
113672535  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
113665190  ubiquitin carboxyl-terminal hydrolase 30-like isoform X1 [KO:K11851] [EC:3.4.19.12]
113676017  tax1-binding protein 1 homolog [KO:K21347]
113664907  sequestosome-1-like [KO:K14381]
113676782  next to BRCA1 gene 1 protein-like [KO:K17987]
113678513  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
113678041  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
113674918  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
113676978  autophagy protein 5-like [KO:K08339]
113675898  autophagy-related protein 9A-like [KO:K17907]
113677874  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
113679721  beclin-1-like [KO:K08334]
113679814  bcl-2-like protein 1 [KO:K04570]
113673713  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
113667521  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
113676995  casein kinase II subunit beta [KO:K03115]
113686292  FUN14 domain-containing protein 1B-like [KO:K17986]
113682736  hypoxia-inducible factor 1-alpha-like [KO:K08268]
113669665  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
113672068  ras-like protein 1 [KO:K07827]
113665105  GTPase HRas [KO:K07827]
113676387  ras-like protein RAS2 [KO:K07830]
113666527  forkhead box protein O3-like [KO:K09408]
113666862  forkhead box protein O1-like [KO:K09408]
113677747  TBC1 domain family member 17-like [KO:K20168]
113664540  TBC1 domain family member 17-like [KO:K20168]
113685608  ras-related protein rab7 isoform X1 [KO:K07897]
113685540  mitochondrial fission 1 protein-like [KO:K17969]
Reference
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
pdam04140  Autophagy - animal
KO pathway
ko04137   
LinkDB

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