KEGG   PATHWAY: rn00030
Entry
rn00030                     Pathway                                
Name
Pentose phosphate pathway
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
rn00030  Pentose phosphate pathway
rn00030

Module
M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:rn00030]
M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:rn00030]
M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:rn00030]
M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:rn00030]
M00008  Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:rn00030]
M00061  D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:rn00030]
M00308  Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P [PATH:rn00030]
M00309  Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate [PATH:rn00030]
M00345  Formaldehyde assimilation, ribulose monophosphate pathway [PATH:rn00030]
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P [PATH:rn00030]
M00631  D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:rn00030]
M00633  Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P [PATH:rn00030]
Other DBs
GO: 0006098
Reaction
R00305  D-glucose:quinone 1-oxidoreductase
R01049  ATP:D-ribose-5-phosphate diphosphotransferase
R01051  ATP:D-ribose 5-phosphotransferase
R01056  D-ribose-5-phosphate aldose-ketose-isomerase
R01057  D-Ribose 1,5-phosphomutase
R01058  D-glyceraldehyde 3-phosphate:NADP+ oxidoreductase
R01066  2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
R01070  beta-D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
R01519  D-Glucono-1,5-lactone lactonohydrolase
R01520  beta-D-Glucose:NAD+ 1-oxoreductase
R01521  beta-D-Glucose:NADP+ 1-oxoreductase
R01522  beta-D-glucose:oxygen 1-oxidoreductase
R01528  6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
R01529  D-Ribulose-5-phosphate 3-epimerase
R01538  D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)
R01541  ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase
R01544  2-amino-2-deoxy-D-gluconate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)
R01621  D-xylulose 5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)
R01641  sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
R01737  ATP:D-gluconate 6-phosphotransferase
R01739  D-gluconate:NADP+ 2-oxidoreductase
R01741  D-Gluconate:(acceptor) 2-oxidoreductase
R01827  sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
R01830  beta-D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
R02032  6-Phospho-2-dehydro-D-gluconate:NAD+ 2-oxidoreductase
R02034  6-phospho-D-gluconate:NADP+ 2-oxidoreductase
R02035  6-Phospho-D-glucono-1,5-lactone lactonohydrolase
R02036  6-Phospho-D-gluconate hydro-lyase(2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)
R02073  diphosphate:beta-D-fructose-6-phosphate 1-phosphotransferase
R02658  ATP:2-dehydro-D-gluconate 6-phosphate
R02736  beta-D-glucose-6-phosphate:NADP+ 1-oxoreductase
R02739  alpha-D-Glucose 6-phosphate ketol-isomerase
R02740  alpha-D-Glucose 6-phosphate ketol-isomerase
R02749  2-deoxy-D-ribose 1-phosphate 1,5-phosphomutase
R02750  ATP:2-deoxy-D-ribose 5-phosphotransferase
R04779  ATP:D-fructose-6-phosphate 1-phosphotransferase
R04780  beta-D-Fructose 1,6-bisphosphate 1-phosphohydrolase
R05338  D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
R05605  2-dehydro-3-deoxy-6-phospho-D-gluconate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
R06620  D-glucose:ubiquinone oxidoreductase
R06836  ATP:ribose-1,5-bisphosphate phosphotransferase
R06837  Ribose 1-phosphokinase
R07147  D-glucose:NADP+ 1-oxidoreductase
R08570  2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
R08571  glyceraldehyde ferredoxin oxidoreductase
R08572  ATP:(R)-glycerate 2-phosphotransferase
R09084  ADP:D-fructose-6-phosphate 1-phosphotransferase
R09780  D-arabino-hex-3-ulose-6-phosphate isomerase
R10221  6-phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating)
R10324  D-glyceraldehyde:acceptor oxidoreductase (FAD-containing)
R10407   
R10408  D-glucosaminate-6-phosphate ammonia-lyase
R10615  D-glyceraldehyde:NADP+ oxidoreductase
R10860  D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase
R10907  beta-D-glucose-6-phosphate:NAD+ 1-oxidoreductase
Compound
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00040  Pentose and glucuronate interconversions
rn00052  Galactose metabolism
rn00230  Purine metabolism
rn00240  Pyrimidine metabolism
rn00340  Histidine metabolism
rn00750  Vitamin B6 metabolism
KO pathway
ko00030   
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