KEGG   PATHWAY: rno04622
rno04622                    Pathway                                
RIG-I-like receptor signaling pathway - Rattus norvegicus (rat)
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Organismal Systems; Immune system
Pathway map
rno04622  RIG-I-like receptor signaling pathway

Rattus norvegicus (rat) [GN:rno]
297989  Ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:]
499801  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
303538  Dhx58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
252961  Tank; TRAF family member-associated NF-kappa-B activator isoform 2 [KO:K12650]
316051  Azi2; 5-azacytidine-induced protein 2 [KO:K12651]
266764  Tbkbp1; TANK-binding kinase 1-binding protein 1 [KO:K12652]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
690894  Ifna1; interferon alpha-5 [KO:K05414]
100912314  interferon alpha-1-like [KO:K05414]
502961  RGD1559679; interferon alpha-1-like [KO:K05414]
500491  Ifna16l1; interferon alpha-1-like [KO:K05414]
24481  Ifnb1; interferon beta precursor [KO:K05415]
313152  Ifnk; interferon kappa precursor [KO:K05441]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
306886  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:]
64044  Casp8; caspase-8 [KO:K04398] [EC:]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
24835  Tnf; tumor necrosis factor [KO:K03156]
84405  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
245920  Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671]
494338  Trim25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:]
312937  Cyld; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:]
361296  Rnf125; E3 ubiquitin-protein ligase RNF125 [KO:K12170] [EC:]
298693  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
365601  Atg5; autophagy protein 5 [KO:K08339]
361321  Atg12; ubiquitin-like protein ATG12 [KO:K08336]
315599  Nlrx1; NLR family member X1 precursor [KO:K12653]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
363452  Otud5; OTU domain-containing protein 5 [KO:K12655] [EC:]
362007  Sike1; suppressor of IKBKE 1 [KO:K12656]
364073  Ddx3y; uncharacterized protein LOC364073 [KO:K11594] [EC:]
317335  Ddx3x; ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:]
298696  Pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:]
361730  Tkfc; triokinase/FMN cyclase [KO:K00863] [EC:]
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nat Immunol 5:730-7 (2004)
Takeuchi O, Akira S
MDA5/RIG-I and virus recognition.
Curr Opin Immunol 20:17-22 (2008)
Yoneyama M, Fujita T
RNA recognition and signal transduction by RIG-I-like receptors.
Immunol Rev 227:54-65 (2009)
Nakhaei P, Genin P, Civas A, Hiscott J
RIG-I-like receptors: sensing and responding to RNA virus infection.
Semin Immunol 21:215-22 (2009)
Moore CB, Ting JP
Regulation of mitochondrial antiviral signaling pathways.
Immunity 28:735-9 (2008)
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Pharmacol Ther 124:219-34 (2009)
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Approaching the RNA ligand for RIG-I?
Immunol Rev 227:66-74 (2009)
Saito T, Gale M Jr
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
J Exp Med 205:1523-7 (2008)
Kawai T, Akira S
Toll-like receptor and RIG-I-like receptor signaling.
Ann N Y Acad Sci 1143:1-20 (2008)
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Immunity 28:651-61 (2008)
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
J Biol Chem 283:36211-20 (2008)
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
J Biol Chem 284:10774-82 (2009)
rno04010  MAPK signaling pathway
rno04120  Ubiquitin mediated proteolysis
rno04210  Apoptosis
rno04630  JAK-STAT signaling pathway
KO pathway

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