KEGG   PATHWAY: sce03420
Entry
sce03420                    Pathway                                
Name
Nucleotide excision repair - Saccharomyces cerevisiae (budding yeast)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
sce03420  Nucleotide excision repair
sce03420

Other DBs
GO: 0006289
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YJL092W  SRS2; DNA helicase SRS2 [KO:K03657] [EC:5.6.2.4]
YOL133W  HRT1; SCF ubiquitin ligase complex subunit HRT1 [KO:K03868] [EC:2.3.2.32]
YER162C  RAD4; Rad4p [KO:K10838]
YEL037C  RAD23; Rad23p [KO:K10839]
YDR030C  RAD28; Rad28p [KO:K10570]
YJR035W  RAD26; DNA-dependent ATPase RAD26 [KO:K10841]
YDL108W  KIN28; TFIIH complex serine/threonine-protein kinase subunit KIN28 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
YDR460W  TFB3; TFIIH/NER complex subunit TFB3 [KO:K10842]
YPR025C  CCL1; TFIIH complex kinase subunit CCL1 [KO:K06634]
YIL143C  SSL2; TFIIH/NER complex ATPase/helicase subunit SSL2 [KO:K10843] [EC:5.6.2.4]
YER171W  RAD3; TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 [KO:K10844] [EC:5.6.2.3]
YDR079C-A  TFB5; TFIIH complex subunit TFB5 [KO:K10845]
YDR311W  TFB1; TFIIH/NER complex subunit TFB1 [KO:K03141]
YLR005W  SSL1; TFIIH/NER complex subunit SSL1 [KO:K03142]
YPR056W  TFB4; TFIIH/NER complex subunit TFB4 [KO:K03143]
YPL122C  TFB2; TFIIH/NER complex subunit TFB2 [KO:K03144]
YGR258C  RAD2; ssDNA endodeoxyribonuclease RAD2 [KO:K10846]
YMR201C  RAD14; DNA repair protein RAD14 [KO:K10847]
YAR007C  RFA1; replication factor A subunit protein RFA1 [KO:K07466]
YNL312W  RFA2; Rfa2p [KO:K10739]
YPL022W  RAD1; ssDNA endodeoxyribonuclease RAD1 [KO:K10848] [EC:3.1.-.-]
YML095C  RAD10; DNA repair protein RAD10 [KO:K10849]
YDL102W  POL3; DNA-directed DNA polymerase delta POL3 [KO:K02327] [EC:2.7.7.7]
YJR006W  POL31; DNA-directed DNA polymerase delta subunit POL31 [KO:K02328]
YJR043C  POL32; DNA polymerase delta subunit POL32 [KO:K03504]
YNL262W  POL2; DNA polymerase epsilon catalytic subunit [KO:K02324] [EC:2.7.7.7]
YPR175W  DPB2; DNA polymerase epsilon noncatalytic subunit [KO:K02325] [EC:2.7.7.7]
YDR121W  DPB4; DNA polymerase epsilon noncatalytic subunit [KO:K02326] [EC:2.7.7.7]
YBR278W  DPB3; DNA polymerase epsilon noncatalytic subunit [KO:K03506] [EC:2.7.7.7]
YJL065C  DLS1; Dls1p [KO:K03506] [EC:2.7.7.7]
YBR088C  POL30; proliferating cell nuclear antigen [KO:K04802]
YOR217W  RFC1; replication factor C subunit 1 [KO:K10754]
YJR068W  RFC2; replication factor C subunit 2 [KO:K10755]
YOL094C  RFC4; replication factor C subunit 4 [KO:K10755]
YNL290W  RFC3; replication factor C subunit 3 [KO:K10756]
YBR087W  RFC5; replication factor C subunit 5 [KO:K10756]
YDL164C  CDC9; DNA ligase (ATP) CDC9 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
sce03020  RNA polymerase
sce04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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