KEGG   PATHWAY: sce04144
Entry
sce04144                    Pathway                                
Name
Endocytosis - Saccharomyces cerevisiae (budding yeast)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sce04144  Endocytosis
sce04144

Other DBs
GO: 0006897
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YOR094W  ARF3; Arf family GTPase ARF3 [KO:K07941]
YDR208W  MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase [KO:K00889] [EC:2.7.1.68]
YKR031C  SPO14; phospholipase D [KO:K01115] [EC:3.1.4.4]
YGL206C  CHC1; clathrin heavy chain [KO:K04646]
YBL037W  APL3; Apl3p [KO:K11824]
YJR005W  APL1; Apl1p [KO:K11825]
YOL062C  APM4; Apm4p [KO:K11826]
YJR058C  APS2; Aps2p [KO:K11827]
YDR388W  RVS167; amphiphysin [KO:K12562]
YLR206W  ENT2; epsin [KO:K12471]
YDL161W  ENT1; epsin [KO:K12471]
YJR125C  ENT3; Ent3p [KO:K12471]
YDR153C  ENT5; Ent5p [KO:K12471]
YBL047C  EDE1; Ede1p [KO:K12472]
YER125W  RSP5; NEDD4 family E3 ubiquitin-protein ligase [KO:K10591] [EC:2.3.2.26]
YOR181W  LAS17; actin-binding protein LAS17 [KO:K23612]
YDL029W  ARP2; actin-related protein 2 [KO:K17260]
YJR065C  ARP3; actin-related protein 3 [KO:K18584]
YBR234C  ARC40; Arc40p [KO:K05757]
YNR035C  ARC35; Arc35p [KO:K05758]
YLR370C  ARC18; Arc18p [KO:K05756]
YKL013C  ARC19; Arc19p [KO:K05755]
YIL062C  ARC15; Arc15p [KO:K05754]
YLL024C  SSA2; Hsp70 family chaperone SSA2 [KO:K03283]
YAL005C  SSA1; Hsp70 family ATPase SSA1 [KO:K03283]
YER103W  SSA4; Hsp70 family chaperone SSA4 [KO:K03283]
YBL075C  SSA3; Hsp70 family ATPase SSA3 [KO:K03283]
YNL209W  SSB2; Hsp70 family ATPase SSB2 [KO:K03283]
YDL229W  SSB1; Hsp70 family ATPase SSB1 [KO:K03283]
YKL007W  CAP1; Cap1p [KO:K10364]
YIL034C  CAP2; F-actin-capping protein subunit beta [KO:K10365]
YHR012W  VPS29; retromer subunit VPS29 [KO:K18467]
YJL053W  PEP8; retromer subunit PEP8 [KO:K18466]
YJL154C  VPS35; retromer subunit VPS35 [KO:K18468]
YOR357C  SNX3; Snx3p [KO:K17918]
YDR069C  DOA4; ubiquitin-specific protease DOA4 [KO:K11839] [EC:3.4.19.12]
YER144C  UBP5; putative ubiquitin-specific protease UBP5 [KO:K11839] [EC:3.4.19.12]
YML001W  YPT7; Rab family GTPase YPT7 [KO:K07897]
YNR006W  VPS27; ESCRT-0 subunit protein VPS27 [KO:K12182]
YHL002W  HSE1; ESCRT-0 subunit protein HSE1 [KO:K04705]
YCL008C  STP22; ubiquitin-binding ESCRT-I subunit protein STP22 [KO:K12183]
YGR206W  MVB12; ubiquitin-binding ESCRT-I subunit protein MVB12 [KO:K12187]
YPL065W  VPS28; ESCRT-I subunit protein VPS28 [KO:K12184]
YPL002C  SNF8; ESCRT-II subunit protein SNF8 [KO:K12188]
YLR417W  VPS36; ESCRT-II subunit protein VPS36 [KO:K12190]
YJR102C  VPS25; ESCRT-II subunit protein VPS25 [KO:K12189]
YMR077C  VPS20; ESCRT-III subunit protein VPS20 [KO:K12195]
YLR025W  SNF7; ESCRT-III subunit protein SNF7 [KO:K12194]
YKL041W  VPS24; ESCRT-III subunit protein VPS24 [KO:K12193]
YKL002W  DID4; ESCRT-III subunit protein DID4 [KO:K12191]
YJL049W  CHM7; Chm7p [KO:K15053]
YPR173C  VPS4; AAA family ATPase VPS4 [KO:K12196]
YLR181C  VTA1; Vta1p [KO:K12199]
YKR035W-A  DID2; Did2p [KO:K12197]
YDR486C  VPS60; Vps60p [KO:K12198]
YNL265C  IST1; Ist1p [KO:K19476]
YOR275C  RIM20; Rim20p [KO:K12200]
YOR069W  VPS5; sorting nexin 1 [KO:K17917]
YPR165W  RHO1; Rho family GTPase RHO1 [KO:K04513]
YKR014C  YPT52; Rab family GTPase YPT52 [KO:K07889]
YOR089C  VPS21; Rab family GTPase VPS21 [KO:K07889]
YDR323C  PEP7; phosphatidylinositol-3-phosphate binding protein [KO:K12481]
YGL095C  VPS45; Vps45p [KO:K12479]
YJL036W  SNX4; Snx4p [KO:K17919]
YFL005W  SEC4; Rab family GTPase SEC4 [KO:K07901]
YGL210W  YPT32; Rab family GTPase YPT32 [KO:K07905]
YER031C  YPT31; Rab family GTPase YPT31 [KO:K07905]
YKL079W  SMY1; Smy1p [KO:K10396]
YLR229C  CDC42; Rho family GTPase CDC42 [KO:K04393]
YIL044C  AGE2; GTPase-activating protein AGE2 [KO:K12486]
YGL181W  GTS1; Gts1p [KO:K12486]
YDR524C  AGE1; GTPase-activating protein AGE1 [KO:K12488]
YDL226C  GCS1; GTPase-activating protein GCS1 [KO:K12492]
YER122C  GLO3; ADP-ribosylation factor GTPase-activating protein [KO:K12493]
YDR170C  SEC7; Arf family guanine nucleotide exchange factor SEC7 [KO:K18442]
YEL022W  GEA2; Arf family guanine nucleotide exchange factor GEA2 [KO:K18443]
YJR031C  GEA1; Arf family guanine nucleotide exchange factor GEA1 [KO:K18443]
YDL192W  ARF1; Arf family GTPase ARF1 [KO:K07937]
YDL137W  ARF2; Arf family GTPase ARF2 [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sce04070  Phosphatidylinositol signaling system
sce04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
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