KEGG   PATHWAY: sclf00331
Entry
sclf00331                   Pathway                                
Name
Clavulanic acid biosynthesis - Streptomyces clavuligerus
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
sclf00331  Clavulanic acid biosynthesis
sclf00331

Module
sclf_M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate [PATH:sclf00331]
Organism
Streptomyces clavuligerus [GN:sclf]
Gene
BB341_29465  decarboxylase [KO:K12673] [EC:2.5.1.66]
BB341_07805  decarboxylase [KO:K12673] [EC:2.5.1.66]
BB341_29470  beta-lactam synthetase [KO:K12674] [EC:6.3.3.4]
BB341_07810  asparagine synthase [KO:K12674] [EC:6.3.3.4]
BB341_07820  clavaminate synthase [KO:K12675] [EC:1.14.11.21]
BB341_13950  clavaminate synthase [KO:K12675] [EC:1.14.11.21]
BB341_29475  agmatinase [KO:K12676] [EC:3.5.3.22]
BB341_07815  agmatinase [KO:K12676] [EC:3.5.3.22]
BB341_07840  oxidoreductase [KO:K12677]
Compound
C00062  L-Arginine
C00118  D-Glyceraldehyde 3-phosphate
C06655  L-N2-(2-Carboxyethyl)arginine
C06656  Deoxyguanidinoproclavaminic acid
C06657  Guanidinoproclavaminic acid
C06658  Proclavaminic acid
C06659  Dihydroclavaminic acid
C06660  Clavaminic acid
C06661  Clavulanate-9-aldehyde
C06662  Clavulanic acid
Reference
PMID:9614345
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Reference
  Authors
Caines ME, Elkins JM, Hewitson KS, Schofield CJ.
  Title
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
  Journal
J Biol Chem 279:5685-92 (2004)
DOI:10.1074/jbc.M310803200
Related
pathway
sclf00220  Arginine biosynthesis
KO pathway
ko00331   
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