KEGG   PATHWAY: sfl05100
Entry
sfl05100                    Pathway                                
Name
Bacterial invasion of epithelial cells - Shigella flexneri 301 (serotype 2a)
Description
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
sfl05100  Bacterial invasion of epithelial cells
sfl05100

Organism
Shigella flexneri 301 (serotype 2a) [GN:sfl]
Gene
CP0126  ipaD; hypothetical protein [KO:K13287]
CP0127  ipaC; IpaC, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [KO:K13286]
CP0128  ipaB; IpaB, secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells [KO:K13285]
CP0125  ipaA; hypothetical protein [KO:K13284]
CP0133  ipgD; hypothetical protein [KO:K13085] [EC:3.1.3.78]
CP0130  ipgB1; protein IpgB1 [KO:K13742]
CP0024  ipgB2; hypothetical protein [KO:K13743]
CP0181  virA; VirA protein [KO:K12785]
Reference
  Authors
Mostowy S, Cossart P
  Title
Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
  Journal
Cell Motil Cytoskeleton 66:816-23 (2009)
DOI:10.1002/cm.20353
Reference
  Authors
Hauck CR, Ohlsen K
  Title
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
  Journal
Curr Opin Microbiol 9:5-11 (2006)
DOI:10.1016/j.mib.2005.12.002
Reference
  Authors
Wang B, Li S, Dedhar S, Cleary PP
  Title
Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
  Journal
Cell Microbiol 9:1519-28 (2007)
DOI:10.1111/j.1462-5822.2007.00889.x
Reference
  Authors
Matsumoto H, Young GM
  Title
Translocated effectors of Yersinia.
  Journal
Curr Opin Microbiol 12:94-100 (2009)
DOI:10.1016/j.mib.2008.12.005
Reference
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
  Authors
Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
  Title
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
  Journal
Cell 130:611-23 (2007)
DOI:10.1016/j.cell.2007.06.043
Related
pathway
sfl03070  Bacterial secretion system
KO pathway
ko05100   
LinkDB

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