KEGG   PATHWAY: suri03410
Entry
suri03410                   Pathway                                
Name
Base excision repair - Serratia ureilytica
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
suri03410  Base excision repair
suri03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Serratia ureilytica [GN:suri]
Gene
J0X03_00165  mutM; bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
J0X03_17710  nei; endonuclease VIII [KO:K05522] [EC:3.2.2.- 4.2.99.18]
J0X03_12680  nth; endonuclease III [KO:K10773] [EC:4.2.99.18]
J0X03_05650  alkA; DNA-3-methyladenine glycosylase 2 [KO:K13529] [EC:3.2.2.21]
J0X03_23675  DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
J0X03_02790  mug; G/U mismatch-specific DNA glycosylase [KO:K03649] [EC:3.2.2.28]
J0X03_04990  ung; uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
J0X03_03185  mutY; A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.31]
J0X03_10315  xthA; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
J0X03_07390  nfo; deoxyribonuclease IV [KO:K01151] [EC:3.1.21.2]
J0X03_24115  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
J0X03_03920  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
J0X03_06230  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
LinkDB

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