KEGG   PATHWAY: suri03430
Entry
suri03430                   Pathway                                
Name
Mismatch repair - Serratia ureilytica
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
suri03430  Mismatch repair
suri03430

Other DBs
GO: 0006298
Organism
Serratia ureilytica [GN:suri]
Gene
J0X03_20050  mutS; DNA mismatch repair protein MutS [KO:K03555]
J0X03_22135  mutL; DNA mismatch repair endonuclease MutL [KO:K03572]
J0X03_04250  mutH; DNA mismatch repair endonuclease MutH [KO:K03573]
J0X03_23090  uvrD; DNA helicase II [KO:K03657] [EC:5.6.2.4]
J0X03_07465  sbcB; exodeoxyribonuclease I [KO:K01141] [EC:3.1.11.1]
J0X03_05375  xseA; exodeoxyribonuclease VII large subunit [KO:K03601] [EC:3.1.11.6]
J0X03_18810  xseB; exodeoxyribonuclease VII small subunit [KO:K03602] [EC:3.1.11.6]
J0X03_14210  exoX; exodeoxyribonuclease X [KO:K10857] [EC:3.1.11.-]
J0X03_03920  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
J0X03_02085  ssb1; single-stranded DNA-binding protein SSB1 [KO:K03111]
J0X03_04525  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
J0X03_23805  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
J0X03_18460  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
J0X03_18005  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
J0X03_14380  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
J0X03_19555  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
J0X03_07470  DNA polymerase II [KO:K02345] [EC:2.7.7.7]
J0X03_14190  DNA polymerase III subunit theta [KO:K02345] [EC:2.7.7.7]
J0X03_21500  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
J0X03_20920  DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
J0X03_06230  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
J0X03_01295  dam; adenine-specific DNA-methyltransferase [KO:K06223] [EC:2.1.1.72]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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