KEGG   PATHWAY: suri03440
Entry
suri03440                   Pathway                                
Name
Homologous recombination - Serratia ureilytica
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
suri03440  Homologous recombination
suri03440

Other DBs
GO: 0000724
Organism
Serratia ureilytica [GN:suri]
Gene
J0X03_03920  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
J0X03_02085  ssb1; single-stranded DNA-binding protein SSB1 [KO:K03111]
J0X03_23800  recF; DNA replication/repair protein RecF [KO:K03629]
J0X03_05070  recO; DNA repair protein RecO [KO:K03584]
J0X03_18450  recR; recombination protein RecR [KO:K06187]
J0X03_19890  recA; recombinase RecA [KO:K03553]
J0X03_24115  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
J0X03_10010  ruvA; Holliday junction branch migration protein RuvA [KO:K03550] [EC:5.6.2.4]
J0X03_10015  ruvB; Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
J0X03_10005  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
J0X03_00075  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
J0X03_04305  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
J0X03_04295  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
J0X03_04310  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
J0X03_04525  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
J0X03_23805  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
J0X03_18460  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
J0X03_18005  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
J0X03_14380  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
J0X03_19555  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
J0X03_07470  DNA polymerase II [KO:K02345] [EC:2.7.7.7]
J0X03_14190  DNA polymerase III subunit theta [KO:K02345] [EC:2.7.7.7]
J0X03_21500  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
J0X03_20920  DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
J0X03_00420  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
J0X03_22035  priB; primosomal replication protein N [KO:K02686]
J0X03_18475  primosomal replication protein [KO:K04067]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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