KEGG   PATHWAY: xco04110
Entry
xco04110                    Pathway                                
Name
Cell cycle - Xiphophorus couchianus (Monterrey platyfish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
xco04110  Cell cycle
xco04110

Other DBs
GO: 0000278
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114133203  14-3-3 protein gamma-B [KO:K16198]
114133890  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
114133894  stag1; cohesin subunit SA-1 [KO:K06671]
114134066  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
114134077  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114134078  bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
114134136  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
114134178  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114134222  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114134249  14-3-3 protein beta/alpha-1-like isoform X1 [KO:K16197]
114134429  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114134689  orc3; origin recognition complex subunit 3 [KO:K02605]
114134789  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114135100  14-3-3 protein beta/alpha-1-like [KO:K16197]
114135107  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
114135419  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114135478  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
114135983  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
114136008  transcriptional regulator Myc-2-like [KO:K04377]
114136109  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
114136140  G1/S-specific cyclin-D2-like isoform X1 [KO:K10152]
114136223  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
114136244  rbl1; retinoblastoma-like protein 1 [KO:K04681]
114136425  cul1; cullin-1 [KO:K03347]
114136975  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114137103  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
114137130  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114137458  F-box only protein 5-like [KO:K10292]
114137548  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
114137813  cdt1; DNA replication factor Cdt1 [KO:K10727]
114137846  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
114138257  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114138264  mad2l1bp; MAD2L1-binding protein [KO:K26093]
114138297  wapl; wings apart-like protein homolog [KO:K25163]
114138392  dbf4; protein DBF4 homolog A [KO:K06629]
114138532  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114138782  stag3; cohesin subunit SA-3 [KO:K06671]
114138792  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
114138799  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
114138802  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
114138837  securin-like [KO:K06635]
114138936  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
114138947  cohesin subunit SA-2-like isoform X1 [KO:K06671]
114139015  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
114139206  ccna2; cyclin-A2 [KO:K06627]
114139436  transforming growth factor beta-2 proprotein-like [KO:K13376]
114141014  orc4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
114141129  double-strand-break repair protein rad21-like protein 1 [KO:K06670]
114141448  cdc14a; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114141462  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
114141517  rad21; double-strand-break repair protein rad21 homolog [KO:K06670]
114141666  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114142141  mtbp; mdm2-binding protein [KO:K26116]
114142194  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
114142331  e2f3; transcription factor E2F3 [KO:K06620]
114142529  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114142693  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
114142996  mothers against decapentaplegic homolog 3 [KO:K23605]
114143123  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114143200  G2/mitotic-specific cyclin-B2-like [KO:K21770]
114143740  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K04681]
114143743  transcription factor E2F4-like [KO:K04682]
114143902  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
114144000  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
114144170  14-3-3 protein zeta/delta-like [KO:K16197]
114144407  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
114144409  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
114144572  cdc6; cell division control protein 6 homolog [KO:K02213]
114144578  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
114144722  cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
114144732  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
114145249  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
114145328  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
114145593  ttk; dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
114145793  cdc20; cell division cycle protein 20 homolog [KO:K03363]
114145865  e2f1; transcription factor E2F1 [KO:K17454]
114146318  transcriptional regulator Myc-like isoform X1 [KO:K04377]
114146456  fizzy-related protein homolog isoform X1 [KO:K03364]
114146649  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
114146761  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114146885  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
114146937  transcription factor E2F5-like [KO:K04682]
114146996  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
114147111  fzr1; fizzy-related protein homolog [KO:K03364]
114147154  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
114147159  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
114147177  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
114147229  14-3-3 protein beta/alpha-1 [KO:K16197]
114147695  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114147705  cohesin subunit SA-2-like isoform X1 [KO:K06671]
114147800  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
114148530  tfdp1; transcription factor Dp-1 [KO:K04683]
114148657  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
114148835  cdc16; cell division cycle protein 16 homolog [KO:K03353]
114149415  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114149470  nipped-B-like protein B isoform X1 [KO:K06672]
114149479  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
114149548  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114149794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
114149816  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114150144  skp2; S-phase kinase-associated protein 2 [KO:K03875]
114150492  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
114150619  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
114151246  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
114151556  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114151621  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
114151812  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
114151974  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
114152019  wings apart-like protein homolog [KO:K25163]
114152253  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
114152335  e2f4; transcription factor E2F4 [KO:K04682]
114152343  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
114152373  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
114152387  protein DBF4 homolog B-like isoform X1 [KO:K06629]
114152467  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114152468  skp1; S-phase kinase-associated protein 1 [KO:K03094]
114152470  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
114152717  ccna1; cyclin-A1 isoform X1 [KO:K06627]
114152867  transcriptional regulator ATRX-like [KO:K10779]
114152955  14-3-3 protein epsilon isoform X1 [KO:K06630]
114153224  rb1; retinoblastoma-associated protein [KO:K06618]
114153281  14-3-3 protein gamma-1 [KO:K16198]
114153322  cohesin subunit SA-2-like isoform X1 [KO:K06671]
114153466  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
114153492  cdc23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
114154283  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114154438  nipped-B-like protein A isoform X1 [KO:K06672]
114154590  ccnh; cyclin-H [KO:K06634]
114154787  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
114154836  mothers against decapentaplegic homolog 4-like [KO:K04501]
114154871  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
114154936  pcna; proliferating cell nuclear antigen [KO:K04802]
114154943  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
114155154  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
114155222  cdc45; cell division control protein 45 homolog isoform X1 [KO:K06628]
114155224  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114155246  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
114155259  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114155341  transcription factor E2F6-like [KO:K06620]
114155581  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
114155632  14-3-3 protein beta/alpha-B-like [KO:K16197]
114155712  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
114155738  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
114156230  sgo1; shugoshin 1 [KO:K11580]
114156288  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114156323  cdca5; sororin [KO:K17390]
114156383  double-strand-break repair protein rad21 homolog [KO:K06670]
114156401  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114156771  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
114156785  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
114156935  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
114156986  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
114157449  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
114157466  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
114157824  tp53; cellular tumor antigen p53 [KO:K04451]
114157928  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
114158174  transforming growth factor beta-3 proprotein-like [KO:K13377]
114158210  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
114158373  knl1; kinetochore scaffold 1 isoform X1 [KO:K11542]
114158524  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114158546  ticrr; treslin isoform X1 [KO:K26117]
114158558  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
114158894  esco2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
114159004  hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
114159065  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
114159703  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
114159833  cyclin-dependent kinase 4-like isoform X1 [KO:K02091] [EC:2.7.11.22]
114159987  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
114160057  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
114160081  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
114160217  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
114160373  G1/S-specific cyclin-D2-like [KO:K10151]
114160562  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114160658  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
114160673  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
114160881  G1/S-specific cyclin-D2-like [KO:K10151]
114160947  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114161104  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
114161405  transforming growth factor beta-1 proprotein-like [KO:K13375]
114161548  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
114161604  G2/mitotic-specific cyclin cdc13-like isoform X1 [KO:K21770]
114161685  structural maintenance of chromosomes protein 1B-like [KO:K06636]
114161922  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114161958  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
114162013  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
xco03030  DNA replication
xco04010  MAPK signaling pathway
xco04120  Ubiquitin mediated proteolysis
xco04210  Apoptosis
KO pathway
ko04110   
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