Physeter catodon (sperm whale): 102974889 Help Entry 102974889         CDS       T06011                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pcad  Physeter catodon (sperm whale) Pathway pcad04020   Calcium signaling pathway pcad04024   cAMP signaling pathway pcad04260   Cardiac muscle contraction pcad04261   Adrenergic signaling in cardiomyocytes pcad04371   Apelin signaling pathway pcad04713   Circadian entrainment pcad04911   Insulin secretion pcad04921   Oxytocin signaling pathway pcad04972   Pancreatic secretion pcad05020   Prion disease pcad05022   Pathways of neurodegeneration - multiple diseases pcad05410   Hypertrophic cardiomyopathy pcad05412   Arrhythmogenic right ventricular cardiomyopathy pcad05414   Dilated cardiomyopathy pcad05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102974889 (RYR2)    04020 Calcium signaling pathway     102974889 (RYR2)    04024 cAMP signaling pathway     102974889 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102974889 (RYR2)    04921 Oxytocin signaling pathway     102974889 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     102974889 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102974889 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     102974889 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     102974889 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     102974889 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     102974889 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     102974889 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     102974889 (RYR2)    05414 Dilated cardiomyopathy     102974889 (RYR2)    05415 Diabetic cardiomyopathy     102974889 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pcad04040]     102974889 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pcad04990]     102974889 (RYR2) Ion channels [BR:pcad04040]  Voltage-gated cation channels   Ryanodine receptor    102974889 (RYR2) Domain-containing proteins not elsewhere classified [BR:pcad04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102974889 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102974889 NCBI-ProteinID:  XP_054937185 Ensembl:  ENSPCTG00005017273 UniProt:  A0A9W2WE37 LinkDB All DBs Position 20:7576156..8140981 Genome browser AA seq 4978 aa AA seqDB search MEILYFTFPYAGCLWRSVMTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSK NVPPDLSICTFVLEQSLSVRALQEMLANTVEKSQGAIDVKKWKFMMKTAQGGGHRTLLYG HAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVR VGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRL LHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFR LRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKSDVGVRKEVDGMGTSEIKY GDSVCFIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTA RVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQ NRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYEL LAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNYIKEGHIKS IISLLDKHGRNHKVLDVLCSLCVCDGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMR PNIFLGVSEGSAQYRKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGN GVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQ GMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEH SREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMN KIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEH TEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGW TYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAE VCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFA FDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFD VGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLP QFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDLMFYRLSMPIECAEVFSK TAAGGIPGAGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRADKDKEATKPEFNNHKDY AQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQ EPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSP GQGRNNNGLEIGCVVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFE LGRIKNVMPLSAGLFKSEHKNAVPQCPPRLHVQFLSDVLWSRMPNQFLKVDVSRISERQG WLVQCVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHAL CSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSI TLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSINNEGYQYSPEFPLDILKAKTIQMLT EAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAG PEEEGESPEKEPCAEDSKREGAAEEENKGGKRSKEGLLQMKLPEPVKLQMCLLLQYLCDC QVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINML LNFKDDKSECPCPEEIQDQLLDFHEDLMTHCGIELDEDGSLDGNSDFTIRGRLLSLVEKV TYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIG GLVRALPKTYTINGISVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFY QHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFD HLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQS CQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALR GEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTPDTEEEEDDTIHMGNAIMTFYAALI DLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLEDLVGVISIAFQMPTIAKDGNVVEPDM SAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALAL NRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSI CGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEE ELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMD SEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPL MKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVD AAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDT LTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEA HQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHA SNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSA LRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQ FGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLD KHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVME VILPMLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMDTLLGNILKIIYNNLGIDEGAWM KRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEVRGDMSEAELLIL DEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREE QNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRRGDRYSMQTSLIVAALKRLLPI GLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKVEDPAIRWQMALYKDLPN RTEDTSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGPKRVDPLHQLV LLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEEDDGEEEVKSFEHDIIKDLRDKFAS LGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGG NSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKV LQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFY WYYSGKDIIDEQGQRNFSKAIHVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYAQSETEFLLSC AETDEDESLDYEEFVQRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYF QPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELF VNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRVGFFSIMTVKSALFALR YNILILMRMLSLKSLKKQMKKVKKMTVKDMVTAFFTSYWGVFMSLLHFVASVCRGFSRIV GSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEDGERKAMEGALPNEDLTDLKEL TEESDLLSDIFGLDLKREGGRYKLIPHNPNAGLSDLMSNPVPVPEVPEKFQEQKAKEEEK EEKEESKSEPEKAEGEDGEKEEKPKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQ KLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAQVGSLDS SSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISEL LGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMAMS VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atggaaatcctgtattttacttttccctatgcaggttgcctttggcgatcagtaatgaca gatgatgaagtggttctgcagtgtactgcaaccatccacaaagaacagcagaaactgtgt ttggccgcagaagggtttggcaacagactttgcttcttggagtccacttcgaattccaag aatgtccccccagacctctccatctgcacctttgtgcttgaacagtccctctctgtccgg gccctgcaggagatgctggctaacactgtggagaagtcacaaggggcaattgacgtgaaa aaatggaaattcatgatgaagaccgctcaaggtggtggccaccgaacgctcctctatgga catgccatattgctgcgccattcctacagcggcatgtatctgtgctgcctgtccacctct cggtcttcaactgataaactggcctttgatgttggcttgcaagaggacacaacaggtgaa gcttgttggtggaccatccatcctgcctccaagcagcgctcagaaggagaaaaagtacgg gttggagatgaccttatcttagttagtgtgtcctccgaaaggtacttgcacttgtcttac ggcaacggcagcttgcacgtggacgccgctttccagcagaccctctggagcgtggcccca atcagctcaggaagtgaagcagcccaagggtatctgattggtggtgacgtcctcaggttg cttcatggacacatggatgaatgcctcacggtcccttcaggagaacacggtgaagagcag cgaagaactgttcattacgaaggtggtgctgtatctgttcacgcacgttccctgtggaga ctagagacgctaagagttgcgtggagtggaagccacataagatggggccagcctttccga ctacgccatgtcacaacaggaaaatacttgagcctcatggaagacaaaagccttctactc atggacaaagaaaaagctgatgtcaaatcaacagcatttaccttccgatcttccaaggaa aaatcggatgtaggggtgaggaaagaagttgatggcatgggaacctctgaaataaaatat ggagactcagtatgctttatacagcatatcaatacgggcttgtggctaacctaccagtct gtggatgtgaaatctgtgagaatgggatccatacagcgtaaggctattatgcatcatgaa ggtcacatggatgatggcctaaatttatccagatctcagcatgaagaatcacggacagca cgtgtcatccggagcacagtcttccttttcaatagatttattaggggccttgatgctctc agcaaaaaggcgaaggcttccactgtagacttacctatagagtctgtaagtctaagtctg caggacctgattggctacttccacccaccagatgagcacttagagcatgaagataagcag aacagattacgagctctaaaaaatcggcagaatctcttccaggaagagggaatgatcaac cttgtgctcgagtgtatagacaggctgcacgtgtacagcagcgctgcacactttgcggat gtcgctgggagagaagcaggggaatcctggaaatcgattctgaattctctgtatgagttg ctggcggctctaattagaggaaatcgtaaaaactgtgctcaattttctggctccctcgac tggttaatcagccgattggaaagactggaagcttcttctggtattcttgaagttttacac tgtgtgttagtagaaagtccagaagctctaaattatattaaagaaggccatattaaatcc attatctcacttttagacaagcatggaagaaatcacaaggttctggacgtcttatgctcc ctctgtgtttgcgatggggtagcggtccgttctaaccagcatctcatctgtgacaatctt ctgccgggaagagacctgttactgcaaacacgccttgtgaaccacgtcagcagcatgaga cccaatatttttctgggtgtcagcgaagggtctgcgcagtataggaaatggtactatgag ttgatggtggaccacaccgaaccatttgtgaccgccgaagccactcacctgcgagtgggc tgggcttcaacggaggggtactctccctaccctggagggggcgaggagtggggtggaaat ggtgtcggagatgacctcttctcctatggatttgatggacttcacctctggtcaggttgt attgcccgtactgtcagctcaccaaaccagcatctgttgagaactgatgatgtcatcagt tgctgtttagatctaagtgccccaagcatctccttccgaattaatggacaacctgttcaa ggcatgtttgagaatttcaacatcgatggcctcttctttccagttgtcagtttctctgca ggaatcaaggtacgctttctgcttggggggagacatggagaatttaagttccttcctccg cccgggtatgctccttgttatgaagctgttctgccaaaagaaaagttgaaagtggaacac agccgagagtacaagcaagaaaggacttatacacgggacctcctgggtcccacagtttcc ctgacacaagccgccttcacaccgatccccgtcgataccagccagattgtgttgcctccc cacctggagaggataagagaaaaactggcagagaatatccatgaactctgggttatgaat aaaattgaacttggctggcagtatggtccggttagagatgacaataagagacagcacccg tgtctggtggagttctccaagctgcctgaacaggaacgcaattacaatttacagatgtca cttgagaccctgaagactttgttggcattaggatgtcatgtgggtatatcagatgaacac accgaagaaaaggtgaaaaaaatgaagctgccaaaaaattaccagctgacaagtggatac aagcctgccccgatggacctgagctttatcaagctcaccccatctcaggaagcgatggtg gacaagttggcggaaaatgctcataacgtgtgggcccgcgatcgaatccggcagggctgg acctatggcatccaacaggatgtaaagaacagaagaaaccctcgcctggttccctatgcc cttctagatgaccgaactaagaaatccaacaaggacagcctccgtgaggccgtgcgcacc ctgctggggtatggctacaacctggaggcgcccgatcaagatcatgctgccagagctgaa gtgtgcagcggcacaggagaaaggttccgaatcttccgcgctgagaagacttatgctgtg aaggcaggaaggtggtattttgaatttgaggctgtcactgctggagacatgagagttggc tggagcaggccaggctgtcaacccgatcaggagcttgggtcggatgaacgtgcctttgct ttcgatggctttaaggcccagcggtggcaccagggcaatgagcactatgggcgctcttgg caagcaggcgatgttgtggggtgtatggttgacatgacagaacataccatgatgttcacg ctgaacggcgaaatccttcttgatgattcgggttcagaattggctttcaaggactttgat gttggtgatggattcatacctgtatgtagccttggagtggctcaagtgggcaggatgaac tttggaaaggatgtcagcaccttgaaatatttcaccatctgtggcttacaagagggctat gaaccatttgccgttaacacgaacagggatattaccatgtggctaagcaagaggcttcct cagtttctccaagttccatcaaaccatgaacatattgaggtgaccagaatagacggcacc atcgacagttccccgtgtttaaaggtcactcagaagtcctttggctctcagaacagcagc acggatctcatgttttatcgtctgagcatgcccatcgagtgcgcggaggtcttctccaag actgcggctggagggatccctggcgccggtctctttgggcccaagaatgatttggaggat tatgatgtggattcggactttgaggttctcatgaagacagctcatggccatctggtgcca gatcgagcggacaaagacaaagaagctacaaaaccagagtttaacaaccacaaagattat gctcaggaaaagccctctcgtctgaaacaaagatttttgcttagaaggacaaagccagat tacagcaccagccattctgcaagactcacagaagacgtcctggcagatgagagggacgac tatgattacttgatgcaaacgtccacgtactattactcagtgagaatctttcctggacaa gaacctgccaatgtctgggtgggctggatcacatccgatttccatcagtatgatacaggc tttgacttggacagagttcgtacagtgaccgtgactctaggagatgaaaaaggaaaggtg catgaaagcatcaaacgcagcaactgctatatggtgtgtgcgggtgagagcctgagcccc gggcaaggacgcaacaacaacggcctggagattggctgcgtggtggacactgccagtggg ttgctcaccttcacggccaacggcaaggagctgagcacatattatcaggtggaaccaagt acaaagttatttcctgcagtttttgcgcaagctacaagtcccaacgtttttcagtttgag ttgggaagaataaagaatgtgatgcctctctcagcgggattattcaagagcgagcacaaa aacgccgtgccgcagtgtccccctcgtctccatgtgcagttcctctcagatgtcctctgg agcagaatgcccaaccagttcttgaaggtagacgtgtctcgaataagtgaacgccaaggc tggctggtgcagtgtgtggaacctctgcagttcatgtctctccatatcccagaggagaac agatctgtggacatcctggaactgaccgagcaggaagaactgctgaaattccactaccat actctccggctctactcggccgtctgcgcgcttgggaatcaccgggtggcccacgccttg tgcagccacgtggacgaaccgcagctgctctacgccatcgagaacaagtacatgcccggc ttgctgcgcaccggctactacgacctgctgattgacatccacctcagctcctacgccacc gccaggctcatgatgaacaatgagttcatcgtccccatgacggaggagacaaagagcatc accctcttccccgatgagaacaaaaagcacggcctcccgggcattggcctcagcacctcc ctcaggccgcggatgcagttttcctccccgagttttgtcagcattaataacgagggttac cagtacagccccgagttcccgctggacatcctgaaggccaagaccatacagatgctgaca gaggccgtgaaagagggcagccttcacgcccgggaccccgtcggggggaccactgagttc ctcttcgtccccctcatcaagctgttctataccctgcttatcatgggcatcttccacaac gaggacttgaaacacatcttgcagttgattgagcccagcgtgttcaaggaagctgccggt cccgaggaggagggcgagtcgccagagaaggagccctgcgcagaagactccaagcgggaa ggagccgctgaggaagaaaacaaagggggtaagaggtccaaggaaggcctgctccaaatg aaactgcccgagccagttaaattgcagatgtgtctgctacttcagtacctctgtgactgc caggtccggcaccggatagaagccattgtggccttttcagatgactttgtagccaagctc caagacaatcaacgattccgctataatgaagttatgcaggccttaaacatgtcggctgca ctcacagccaggaagacaaaggaattcagatcaccgcctcaagagcagataaatatgctt ctcaattttaaggatgacaaaagcgaatgtccatgtcccgaagaaatccaagaccaactc ttagattttcatgaagatttgatgacacattgtggaattgagctggatgaagatgggtct ctggatggaaacagtgattttacaattagaggacgcctgctgtccttggtagaaaaggtg acatacctaaagaagaagcaagctgaaaagcccgttgagagtgactccaagaagtcgtcc actcttcagcagttgatttctgagaccatggtccgatgggctcaagagtctgttattgaa gaccctgagttggtgagggccatgttcgtgttgctccatcgacagtatgatggcattggg ggtctggtccgggctctgccaaagacctacactataaatggtatttccgtggaggatacc atcaacctgctggcatctcttggtcagattcgttctctgctgagtgtgagaatgggcaaa gaagaagagaaacttatgattcgtggattaggggatatcatgaataataaagtgttttac cagcaccctaatctcatgagggcacttgggatgcacgagacagtgatggaggtcatggtg aatgtccttggaggtggggagtccaaggaaatcacttttcccaagatggtggccaactgt tgccgttttctctgttacttctgtcgtataagtaggcagaatcagaaagcaatgttcgat catctcagttatttactggaaaacagcagtgttggtcttgcctcaccagctatgagaggt tcaacgccactggacgtggcagcagcctcagtgatggataataatgaactagccttagct ttgcgggagccagatctggaaaaggtagtgcgctatttggctggttgtggactgcaaagt tgtcagatgctggtgtcgaagggttatccagacattgggtggaatccagttgaaggagag agatatcttgactttctcagatttgctgtcttctgtaatggggaaagcgtggaggagaat gcaaatgtcgtggtgagattgctcatccggaggcctgagtgtttcggtcctgccttgagg ggggaaggtgggaatggtctgctcgcagccatggaagaagccataaaaatagctgaggat ccttctcgagatggtccctcaccaactagtggatccagcaaaacccctgatacagaagag gaggaagatgataccatccacatggggaatgccatcatgacattttatgcagctttgatt gacctgttaggacgctgtgctcccgaaatgcatttgattcatgctgctaagggagaagcc atcagaatcaggtctattttgagatccctgattccactggaagatttggtgggagtaatc agcattgcttttcagatgccaacgatagccaaagatgggaatgtggtggagcctgacatg tctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagggtctat ggaattgaggttcaagatttcctcctccatcttctcgaggttggctttctgccagatctg cgggctgctgcttctttagatacggctgctttgagcgctacagacatggccctggccctc aatcggtacctttgcacggccgtgttgcctttgttaacaagatgtgctcctctttttgct ggcactgagcaccatgcttccctcattgactcattacttcacaccgtgtacagactttct aagggctgctcacttaccaaagctcaacgagattccatagaagtgtgtttactctctatt tgtggccaattgagaccttctatgatgcagcacttactcagaagattagtatttgatgtc ccattattaaatgaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaaga tgctggaaatactactgcctgcctggagggtggggaaactttggagctgcctcagaagaa gaacttcatttatcaagaaagttgttctggggcatttttgatgccctgtctcaaaagaaa tatgaacaagaacttttcaaactggcactgccttgcctgagtgcagttgcgggagctttg cctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggat tctgaagggaactttaacccacaacctgttgatacctcaaatattacaattcctgagaag ttggaatacttcattaacaaatatgcagaacattcccatgacaagtggtcaatggacaag ttggcaaatggatggatttatggagaaatatattcagactcgtctaaagttcaaccatta atgaagccatataaactattatctgaaaaggaaaaagaaatttatcgctggccaatcaaa gaatctttaaaaactatgctggcctgggggtggagaattgaaagaacacgggagggagac agcatggccctttataaccggactcgtcgtatttcccagacaagccaggtttctgtagat gccgcccatggttatagcccccgagccattgacatgagcaatgttacactatccagagat ctgcatgctatggcggaaatgatggctgaaaactaccataatatatgggcaaagaaaaag aaactggaactggagtccaaaggaggtggaaaccatcccctgctggtaccctatgataca ctgacggccaaagagaaagccaaggatagggaaaaagcacaggacatcctcaagttcctg cagatcaatggctatgctgtatccagaggattcaaggacctggaattggacactccttct attgagaaacgatttgcctatagtttccttcagcaactcattcgctatgtggacgaagcc caccagtatatcctggagtttgatggtggcagcagaagcaaaggagaacatttcccttat gaacaagaaatcaagttctttgctaaagttgttcttcctttaattgatcagtatttcaaa aaccatcgtttatacttcttatctgcagcaagcagacctctctgttctggaggacatgca tcaaacaaagagaaagaaatggtgactagcctattctgcaaacttggagttcttgtcagg cataggatttcactatttggaaatgatgcaacatcaattgtcaactgtcttcatattttg ggtcagactttggatgcaaggactgtgatgaagactggcctggaaagtgtcaaaagtgcg ctcagagctttcctggacaatgccgcagaggatctggagaagacgatggaaaatcttaag cagggccagttcacccacacccgaaaccaacccaaaggtgttactcagattatcaattat accacggtggcactgttgccaatgctgtcatcattatttgagcatattggccagcatcag ttcggagaagatctaatattggaagatgtacaggtatcatgttatagaattctgactagc ttgtatgcattgggaaccagcaagagtatttatgtggaaaggcaacgttctgcattagga gagtgtctggctgcctttgctggtgcctttcctgtagcatttttggaaactcatctcgac aaacacaatatttactccatctacaatactaagtcttctcgagagagagcagctcttaat ttgccaactaatgtcgaagatgtttgtccaaatataccatctttggagaaactcatggaa gaaattgtggacttagctgagtccggtattcgctacacacaaatgccacatgtgatggaa gttatcctgcccatgctgtgtagctacatgtctcgttggtgggagcacggacccgagaat aacccagggagggctgagatgtgctgcacggctctgaactcagagcacatggacacgctg ctgggaaatatcctgaaaatcatatataataacttggggattgatgagggagcctggatg aaaaggttagcagtattttcccagcctattataaataaagtgaaacctcagctcttgaaa actcatttcttgccattaatggagaaactcaagaaaaaggcagcgatggtggtatcagag gaagaccatctgaaatccgaggtcaggggggatatgtccgaggctgaacttctcattcta gacgagttcaccacgctggccagagatctctatgccttctacccgctcttgattagattt gtggactataacagggcaaagtggctaaaagagcctaacccagaagcagaagatcttttc cgcatggttgcagaggtgtttatctactggtcaaaatcccataatttcaaaagagaagag cagaacttcgtggtacagaatgaaatcaacaatatgtctttccttattacggacaccaag tcaaagatgtccaaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcagagga gaccggtattccatgcagacctctcttatcgtggcagctctgaagcgattactgcccatt ggcttgaacatctgtgcccctggggaccaggagctcattgctctggccaaaaatcgattt agtctgaaagacactgaggatgaagttcgagatataatccgcagtaatattcacttacaa ggcaaggtggaggaccctgctattagatggcagatggctctttacaaagatttacccaac aggacagaagacacttcagatcctgagaagacagtggaaagggtcttggatatagcaaat gtgctttttcatcttgaacaggtcgagcatcctcagagatcgaaaaaggctgtgtggcac aaactgctctctaagcagaggaaacgggcagtggttgcctgctttcggatggctccttta tataatctgccaaggcatcgggctgtcaatctctttcttcagggatatgaaaaatcttgg attgagacagaagaacattactttgaagataaactgatagaagatttagcgaaacctgga gcagaacctcctgaagaagatgaaggccctaagcgggttgatcctctccatcagctggtc cttctgttcagtcgaacggctttaacggagaaatgcaaactggaggaagattttttatat atggcttatgcagatattatggcaaagagttgtcatgacgaggaagaggatgatggggaa gaggaagtgaagagttttgaacacgatattatcaaagatttaagagacaaatttgccagc ctcggcgagaactctctggaaaaagaaatggaaaagcaaaagcttctgtaccaacaagcc aggctccacgaccgcggtgcagctgagatggtgctgcagaccatcagtgccagcaaaggt gaaactggacccatggtggctgctactttgaaacttggaattgctatcttaaatggcggg aactctacagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttc tttcagagccttgctggcctgatgcagtcatgcagtgtccttgacctaaacgcatttgag cgacaaaacaaagctgaaggactcgggatggtgaccgaggaaggatcaggagaaaaggtt ctgcaggatgatgaattcacctgtgacctcttccgcttcttgcaactgctgtgcgaggga cacaactcagattttcaaaattatctgagaactcagactggcaataatacgactgtcaac ataatcatctctactgtagactacctactgagagttcaggaatcaatcagtgacttctat tggtattactctgggaaagatatcattgatgaacaaggacaaaggaatttctccaaagcg attcacgtagcaaaacaagtctttaacacgcttacagagtatattcagggtccttgcact ggcaaccagcagagtttggctcacagcaggctctgggatgcggtggtgggttttcttcat gtatttgcccacatgcagatgaaactgtctcaggattccagtcaaattgagctgctaaaa gaattgatggatcttcagaaggacatggtggtcatgttgctgtccatgttggaaggcaat gtcgttaatggcaccatcggcaaacagatggttgatatgctcgtggaatcttccaacaac gtggagatgattctcaaattttttgacatgttcttaaaactcaaggacttgacgtcttcg gatacctttaaagagtatgacccagacggtaagggagtcatctccaagagggacttccac aaagcgatggagagccataagcactacgcccaatccgagaccgaatttctgctgtcctgc gcagagacggatgaagacgagagcctggattatgaggaatttgtccagcggttccacgag cctgccaaggacatcggcttcaacgtggcggtgcttctgacaaacctttccgaacacatg cccaacgacacccggctgcagaccttcctggagttggccgagagcgtcctgaattacttc cagccctttctgggccgcatcgagatcatgggcagtgccaagcgcatcgagagggtttac tttgaaatcagtgagtccagccgaacccagtgggagaagccccaggtcaaggagtccaaa aggcagtttatatttgatgtggtcaacgaagggggagaaaaggagaagatggagctcttc gtgaacttctgtgaggacaccatatttgagatgcagctcgcggctcagatctcagagtcg gatttgaacgagaggtcagcgaataaagaggagagtgagaaggagaagccagaggagcag gggccgagggtgggtttcttttccatcatgacggtcaagtcggccctgtttgccctcagg tataatatcttgatccttatgcggatgctcagcttaaagagcctgaagaagcagatgaag aaggtgaagaagatgacggtgaaggacatggtcacggccttctttacgtcctactggggg gtttttatgagcctcctgcacttcgtggcgagcgtttgcagaggcttctcccgcatcgtc ggcagcctcctgctgggaggaagcctggtggaaggtgcgaagaagatcaaggtggcggag ctcttggccaacatgccagaccccacgcaggatgaggttcgaggagacggggaggatggg gagaggaaagccatggaaggcgccctgcccaacgaagatctgacggacttaaaggaactg acagaggagagtgacctgctttctgacatctttggcttggacctgaagcgagaaggcggg cggtacaaactgattccccataatcccaatgctggcctgagcgacctcatgagcaacccc gtccctgtccccgaggtgccagaaaagttccaggaacagaaggcaaaagaagaagaaaag gaagaaaaagaagaaagcaaatccgaacctgagaaagccgagggagaagatggagaaaaa gaagaaaaacccaaagaagataagggtaaacagaaattgaggcagctccacacacacaga tatggagagccagaagttcctgagtcagcattctggaagaaaatcatagcctatcaacag aaacttctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtc gcgtttgcaatcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaa ggaaaggagctccccactcgtagttcaagtgaaaatgcccaagttggcagcctggacagc agctcgcctagaatcattgcagttcactatgtgctggaggagagcagcggctacatggag cccacgctgcgtatcttagccattttgcacacggttatctctttcttctgcatcattgga tactactgcttgaaagtcccactggttatttttaagcgagaaaaggaagtagctcgaaaa ttggaatttgatgggctttatattacagaacagccttcagaagatgatattaaaggccag tgggatagactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgtt aaaagaaaggttatggataaatatggagagttctatggccgagacagaatcagcgagtta cttggcatggacaaagctgccctggacttcagcgatgcccgggaaaagaagaagccaaag aaagacagctccctgtcggccgtgctgaactctattgatgtgaagtatcagatgtggaaa ctaggagtcgttttcactgacaattccttcctctaccttgcctggtatatggccatgtcc gttctcggacactataacaacttcttttttgccgctcatcttcttgacattgctatggga ttcaagacgttaagaaccatcttgtcatcagtaacacacaatggcaaacagcttgtatta accgttggcttattagctgttgtcgtatacctgtatactgtcgtggcattcaattttttc cgaaaattctacaataaaagtgaagatggcgatacaccggacatgaaatgtgatgacatg ctaacgtgctatatgttccacatgtatgtcggggtacgtgctggagggggtatcggtgat gaaatcgaagacccagccggcgatgaatatgagatctatcgaatcatctttgacatcacc ttcttcttctttgtaattgtcattctcttggccataatacaaggtttaattatcgatgct tttggggaactaagagaccaacaggaacaggtcaaagaagacatggagaccaagtgcttc atctgtgggataggcaatgattactttgacaccgtgccccatggctttgaaacccacact ttacaggaacacaacttggccaattatctgttttttctgatgtatctcataaacaaagat gaaacagagcacacaggacaggaatcttatgtttggaagatgtatcaagaaaggtgctgg gaatttttcccggctggagattgtttccggaaacagtacgaagaccagctaaattaa

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