KEGG   PATHWAY: pcs03015Help
Entry
pcs03015                    Pathway                                

Name
mRNA surveillance pathway - Penicillium rubens
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
pcs03015  mRNA surveillance pathway
pcs03015

Ortholog table
Module
pcs_M00399  Cap binding complex [PATH:pcs03015]
Other DBs
BSID: 193454
GO: 0071028
Organism
Penicillium rubens [GN:pcs]
Gene
Pc12g04560  Pc12g04560 [KO:K12882]
Pc13g04070  Pc13g04070 [KO:K12883]
Pc06g00100  Pc06g00100 [KO:K14328]
Pc18g03980  Pc18g03980 [KO:K12876]
Pc13g13540  Pc13g13540 [KO:K12877]
Pc21g15180  Pc21g15180 [KO:K13025] [EC:3.6.4.13]
Pc21g23620  Pc21g23620 [KO:K14324]
Pc13g05610  Pc13g05610 [KO:K14325]
Pc22g16240  Pc22g16240 [KO:K12881]
Pc21g03160  Pc21g03160 [KO:K12881]
Pc16g10160  Pc16g10160 [KO:K14284]
Pc13g07320  Pc13g07320 [KO:K14285]
Pc22g24000  Pc22g24000 [KO:K12812] [EC:3.6.4.13]
Pc22g13290  Pc22g13290 [KO:K14294]
Pc20g06520  Pc20g06520 [KO:K13171]
Pc12g09290  Pc12g09290 [KO:K00565] [EC:2.1.1.56]
Pc16g02770  Pc16g02770 [KO:K14396]
Pc21g14600  Pc21g14600 [KO:K14397]
Pc06g01240  Pc06g01240 [KO:K14376] [EC:2.7.7.19]
Pc21g06240  Pc21g06240 [KO:K14399] [EC:2.7.1.78]
Pc22g10080  Pc22g10080 [KO:K14401]
Pc12g15810  Pc12g15810 [KO:K14402]
Pc21g23430  Pc21g23430 [KO:K14403] [EC:3.1.27.-]
Pc22g25210  Pc22g25210 [KO:K14404]
Pc21g20550  Pc21g20550 [KO:K14405]
Pc21g11350  Pc21g11350 [KO:K15541]
Pc13g04390  Pc13g04390 [KO:K15542]
Pc21g07560  Pc21g07560 [KO:K14962]
Pc16g09820  Pc16g09820 [KO:K06269] [EC:3.1.3.16]
Pc18g06430  Pc18g06430 [KO:K06269] [EC:3.1.3.16]
Pc18g05150  Pc18g05150 [KO:K15544] [EC:3.1.3.16]
Pc16g10490  Pc16g10490 [KO:K14407]
Pc13g09250  Pc13g09250 [KO:K14408]
Pc21g05260  Pc21g05260 [KO:K06100]
Pc22g08010  Pc22g08010 [KO:K14411]
Pc16g09030  Pc16g09030 [KO:K13126]
Pc20g00710  Pc20g00710 [KO:K03265]
Pc12g10180  Pc12g10180 [KO:K03267]
Pc13g13030  Pc13g13030 [KO:K14326] [EC:3.6.4.-]
Pc16g11570  Pc16g11570 [KO:K14326] [EC:3.6.4.-]
Pc13g12330  Pc13g12330 [KO:K14326] [EC:3.6.4.-]
Pc12g06250  Pc12g06250 [KO:K14327]
Pc21g20690  Pc21g20690 [KO:K04382] [EC:3.1.3.16]
Pc18g02160  Pc18g02160 [KO:K03456]
Pc12g03110  Pc12g03110 [KO:K04354]
Pc21g15490  Pc21g15490 [KO:K11584]
Pc12g10680  Pc12g10680 [KO:K14416]
Pc13g01540  Pc13g01540 [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   
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