KEGG   PATHWAY: pic04011
Entry
pic04011                    Pathway                                
Name
MAPK signaling pathway - yeast - Scheffersomyces stipitis
Description
The S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third (Hog1) is necessary for survival under hyperosmotic conditions. A fourth (Slt2/Mpk1) is required for repair of injuries to the cell wall. As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence. The MAPK is phosphorylated by the MAPK/ERK kinase (MAPKK/MEK), which is itself phosphorylated by a MEK kinase (MAPKKK/MEKK).
Class
Environmental Information Processing; Signal transduction
Pathway map
pic04011  MAPK signaling pathway - yeast
pic04011

Other DBs
GO: 0000165
Organism
Scheffersomyces stipitis [GN:pic]
Gene
PICST_48016  mating factor alpha precursor [KO:K11234]
PICST_48085  fungal pheromone mating factor STE2G-protein-coupled receptor [KO:K11213]
PICST_37890  STE3; a-factor receptor [KO:K04627]
PICST_65270  YCK2; casein kinase I [KO:K02218] [EC:2.7.11.1]
PICST_89119  YCK1; casein kinase I [KO:K02218] [EC:2.7.11.1]
PICST_65602  predicted protein [KO:K10591] [EC:2.3.2.26]
PICST_35327  guanine nucleotide-binding protein alpha subunit [KO:K19860]
PICST_60945  predicted protein [KO:K04536]
PICST_36268  predicted protein [KO:K19838]
PICST_91075  predicted protein [KO:K11236]
PICST_35277  CDC42; Cell division control protein 42 homolog [KO:K04393]
PICST_66424  RGA1; Rho-type GTPase-activating protein [KO:K19839]
PICST_66478  predicted protein [KO:K19840]
PICST_80106  BEM1; Bud Emergence Mediator [KO:K11237]
PICST_84188  CST20; serine/threonine kinase [KO:K04409] [EC:2.7.11.1]
PICST_82371  Serine/threonine-protein kinase [KO:K19833] [EC:2.7.11.1]
PICST_69620  regulator of budding [KO:K11238]
PICST_67318  predicted protein [KO:K11228] [EC:2.7.11.25]
PICST_39840  predicted protein [KO:K19841]
PICST_33851  STE7; Serine/threonine-protein kinase STE7 homolog [KO:K11226] [EC:2.7.12.2]
PICST_33003  serine/threonine protein kinase [KO:K04371] [EC:2.7.11.24]
PICST_38082  ERK1; Extracellular signal-regulated kinase 1 (ERK1) (MAP kinase 1) (MAPK 1) [KO:K04371] [EC:2.7.11.24]
PICST_80995  PTP2; protein tyrosine phosphatase [KO:K19806] [EC:3.1.3.48]
PICST_88742  CPP1; tyrosine-protein phosphatase [KO:K11240] [EC:3.1.3.48]
PICST_84653  STE-like transcription factor [KO:K11215]
PICST_67950  MCM1; transcription factor of the MADS box family [KO:K12412]
PICST_33957  predicted protein [KO:K06652]
PICST_90135  CDC28; cell division control protein [KO:K04563] [EC:2.7.11.22]
PICST_67502  WSC1; beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain [KO:K11244]
PICST_42612  ROM2; Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-binding Protein [KO:K19842]
PICST_61902  GDP GTP exchange factor [KO:K19843]
PICST_79239  STT4; phosphatidylinositol-4- kinase involved in protein kinase C pathway [KO:K00888] [EC:2.7.1.67]
PICST_64487  MSS4; Phosphatidylinositol-4-phosphate 5-kinase [KO:K00889] [EC:2.7.1.68]
PICST_30484  predicted protein [KO:K04513]
PICST_35392  RHO1; GTP-binding protein, rho subfamily [KO:K04513]
PICST_40058  predicted protein [KO:K04513]
PICST_44196  BEM2; bud-emergence protein [KO:K19844]
PICST_91378  SAC7; GTPase activating protein (GAP) for RHO [KO:K19845]
PICST_85469  predicted protein [KO:K17971]
PICST_81215  protein kinase C [] [KO:K02677] [EC:2.7.11.13]
PICST_83871  PKH2; aspartic proteinase precursor [KO:K06276] [EC:2.7.11.1]
PICST_924  PKH1; serine/threonine protein kinase [KO:K06276] [EC:2.7.11.1]
PICST_76656  predicted protein [KO:K11229] [EC:2.7.11.25]
PICST_35816  predicted protein [KO:K08294] [EC:2.7.12.2]
PICST_66681  SPA2; spindle pole antigen [KO:K19846]
PICST_18249  predicted protein [KO:K04464] [EC:2.7.11.24]
PICST_68747  RLM1; transcription factor of the MADS box family [KO:K09265]
PICST_38184  FKS3; 1,3-beta-glucan synthase (FKS3) [KO:K00706] [EC:2.4.1.34]
PICST_67249  GSL2; 1,3-beta-D-glucan synthase subunit (BGS3) (GSC2) [KO:K00706] [EC:2.4.1.34]
PICST_86938  GSC2; 1,3-beta-glucan synthase component [KO:K00706] [EC:2.4.1.34]
PICST_45484  DNA-directed RNA polymerase II regulator [KO:K15174]
PICST_65402  regulatory protein [KO:K06649]
PICST_75432  SWI6; transcription factor involved in cell cycle dependent gene expression [KO:K06648]
PICST_42742  predicted protein [KO:K02555] [EC:3.1.3.48]
PICST_81868  CLB2; G2/mitotic-specific cyclin [KO:K23469]
PICST_67104  predicted protein [KO:K19850]
PICST_84973  SLN1; histidine kinase osmosensor Osmolarity two-component system protein SLN1 [KO:K11231] [EC:2.7.13.3]
PICST_40734  putative response regulator phosphotransferase [KO:K11232]
PICST_32546  predicted protein [KO:K11233]
PICST_28119  SSK2; Suppressor of Sensor Kinase (SLN1) [KO:K11230] [EC:2.7.11.25]
PICST_40600  protein-tyrosine kinase [KO:K11227] [EC:2.7.12.2]
PICST_54431  predicted protein [KO:K04441] [EC:2.7.11.24]
PICST_56574  predicted protein [KO:K19704] [EC:3.1.3.16]
PICST_83071  GPD2; glycerol-3-phosphate dehydrogenase [KO:K00006] [EC:1.1.1.8]
PICST_90446  GPD1; glycerol-3-phosphate dehydrogenase [KO:K00006] [EC:1.1.1.8]
PICST_33273  MSN4; zf-C2H2 Zinc finger, C2H2 type [KO:K09468]
PICST_40324  CAT1; Peroxisomal catalase (PXP-9) [KO:K03781] [EC:1.11.1.6]
PICST_32703  bZIP protein that binds to CRE motifs, interacts with Mig1p [KO:K09051]
PICST_66638  SSN6; glucose repression mediator protein [KO:K06665]
PICST_63551  transcriptional repressor TUP1 [KO:K06666]
PICST_32463  GRP3.1; protein induced by osmotic stress [KO:K17741] [EC:1.1.1.283]
PICST_58065  GRP3.3; dihydroflavonol-4-reductases [KO:K17741] [EC:1.1.1.283]
PICST_72153  GRE2; NADPH-dependent methylglyoxal reductase GRE2 [KO:K17741] [EC:1.1.1.283]
PICST_67855  serine/threonine-protein kinase HSL1 [KO:K02515] [EC:2.7.11.-]
PICST_46913  SKB1; methyltransferase family protein [KO:K02516] [EC:2.1.1.320]
PICST_35572  predicted protein [KO:K03114] [EC:2.7.11.1]
PICST_84881  BMH1; Multifunctional chaperone (14-3-3 family) Posttranslational modification, protein turnover [KO:K06630]
PICST_11262  RNA polymerase II transcription factor [KO:K09448]
Reference
PMID:15690603
  Authors
Bardwell L
  Title
A walk-through of the yeast mating pheromone response pathway.
  Journal
Peptides 26:339-50 (2005)
DOI:10.1016/j.peptides.2004.10.002
Reference
PMID:15944456
  Authors
Levin DE
  Title
Cell wall integrity signaling in Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 69:262-91 (2005)
DOI:10.1128/MMBR.69.2.262-291.2005
Reference
PMID:22174182
  Authors
Levin DE
  Title
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway.
  Journal
Genetics 189:1145-75 (2011)
DOI:10.1534/genetics.111.128264
Reference
PMID:17875410
  Authors
Hohmann S, Krantz M, Nordlander B
  Title
Yeast osmoregulation.
  Journal
Methods Enzymol 428:29-45 (2007)
DOI:10.1016/S0076-6879(07)28002-4
Reference
PMID:23028184
  Authors
Saito H, Posas F
  Title
Response to hyperosmotic stress.
  Journal
Genetics 192:289-318 (2012)
DOI:10.1534/genetics.112.140863
Reference
PMID:22219507
  Authors
Cullen PJ, Sprague GF Jr
  Title
The regulation of filamentous growth in yeast.
  Journal
Genetics 190:23-49 (2012)
DOI:10.1534/genetics.111.127456
Reference
PMID:9841672
  Authors
Gustin MC, Albertyn J, Alexander M, Davenport K
  Title
MAP kinase pathways in the yeast Saccharomyces cerevisiae.
  Journal
Microbiol Mol Biol Rev 62:1264-300 (1998)
Reference
PMID:17604854
  Authors
Chen RE, Thorner J
  Title
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1773:1311-40 (2007)
DOI:10.1016/j.bbamcr.2007.05.003
KO pathway
ko04011   
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