Pempheris klunzingeri: 139217489 Help Entry 139217489         CDS       T11454                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism pklu  Pempheris klunzingeri Pathway pklu04020   Calcium signaling pathway pklu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:pklu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     139217489 (ryr3)    04020 Calcium signaling pathway     139217489 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pklu04040]     139217489 (ryr3) Ion channels [BR:pklu04040]  Voltage-gated cation channels   Ryanodine receptor    139217489 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Other DBs NCBI-GeneID:  139217489 NCBI-ProteinID:  XP_070704900 LinkDB All DBs Position 18:complement(16487795..16594000) Genome browser AA seq 4844 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVATIQKEHRKFCLAVEGLGNRLCYLESTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGQSSEGAAQGGGHRTLLYGHAILLRHSFSGMYLTC LKTSRSLTDKLSFDVGLQEDSIGEACWWTIHPASKQRSEGEKVRIGDDMILVSVSTERYL HLSISNGNSQVDASFMQTLWNIQPTCSSGNMLVGYLIGGHVMRLCRGHDESLTIPGADKS EEEQSIVNFEAGKGASKARSLWRLEPLRISWSGSHIRWGQAFRLRHLSTGHYLGLTEDRG LVLQDREKSDTAATAFCFRPSKEKVDFGPKRDIDGMGVPEIKYGDSVCFIMHVATGLWLS YLSPDAKSSRLGPIKRRACLHSEGHTDDGLSLQRCQHEESRAARIIRNTTFLFTNFINAL DRIAEGETMDMAGYVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQDLFKDEGM LALLSKCIDRMNLYNSAVHFGEMAGEEAGAAWKDILNLLYELLAALIRGNRNNCTQFSRN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNDVQSMRPNVFLGVAEGSAQYKKWY FELVIDQVDHFVTGEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSFDGLYLWS GRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTEGFFFPVVSF SAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHEGVRDMLGTT QFLSQASFIPTPVDTSQIVLPPHLDNVRDKLAENIHELWGMNKIELGWTYGKVRDDNKRQ HPCLVDFTKLPETERNYNVQMSSETLKTLLALGCHVGQVNVHAEDDLKKIKLPKDYMMSN GYKPAPLELSDVKLTAGQEALVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSRRNPRLVP YALLDERTKKSNRDSLREAIRTMVGYGYDIDPPDQEAPHVVDDQSVETIRLFRVEQTYAV TTGKWYFEFEALSGGDMRVGWARPGCRPDVELGVDDQAFVFDGYRGRRMHAGSRYFGLPW KKGDVVGCMINMEDKSMIFTLNGELLITSKGSELCFTDFETEDGFIPVCSLGMSQIGRMN LGKDASTFKYYTMCGLQEGFEPFAVNMNREITMWFSKRLPTFVNIPKDHMYIEVTRIDGT VDSPPCLKVTHKTFGTQNSNNDMAYCRLSMPVEFYSADKLLDESLKLSHPTKEDGTVDYG SITTYYHSVRVFAGQDPASVWVGWVTPDYHYHSKNFSLSKTRRVTVTLGDERGRVHESVQ RSNCYMVCGADAVGPSSTSRSNSDLEIGCLIDLATGLVSFTANGKELSTTYQVEPNTKLF PAVFVRPTSANLFQFEFVKIKDAMPLSSAIFKSEHRNPVPQCPPRVDVQSIVAVLWSRMP NTFLSVETARVSERHGWVVQCLEPLQMLAVHIPEENRCLDILELSEYEDLRKFHYHTLKL YCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNALISVHLETAKEARLM MNNEFIIPVTDETRSIKLFPDESKQHSLPGVGLSTSLKPRVNFSPVGIINTKRHQYLLSP QIPLGVLKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMGVLTSEEVR LILLLIDPNVFGEAKEGEEVKGDEVAVAGEKEEVSKNEEKAVEAGEEETKEGKPLVKGLL EKSLPEPVKQQMCELLHYFCDCELRHRIEAIVSFSDSFVSKLQYNQKFRYNELMLALNMS AAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPETIQDELNSFHEELRLHCGIPVEEEE EEQDTSIKGRLLALLYKIKGPPQKTEEEPTEKEQAAPTNLKELISQTITSWAQEYHIQDP ELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLSVRMGNEE EKLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPKMVASCCR FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNNGLALALE EPDLEKVVTYLAGCGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFAVFCNGESVEENAN VVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPKTANGVTAGPGEEEGE VIHMGNSIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTTDLVGIISIPL KMPVVNKDGTVTEPDMSASFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFLPDLRASA SLDTEVLSTTETALAMNRYIGSALLPLLTRCAALFAGTEHYAQLIDSTLHTIYRLSKGRS LTKAQRDAIEDCLLAICKHLRPSMMQQLLRRLVFDVPMLTEYCKIPLRLLTNHYEQNWKY YCLPSGMGSFGIASEEELLLTKKLFWGIFDSLSQKKYDAELFKMANLCLCAIAGALPPDF VDASLGATLEKQASVDAQGNFDPKPINTANISLPEKLDYIANKYAEHSHDKWSSEKVSAG WKHGDSLDEQAKTHPLLKPYKALSEKERETYRWPVKESLKSMLTMGWNIERTKEGEAMFQ QRESEKQRKTSESQVNGFSPAPMDLRSVTLSREIQGMVEVVAENYHNIWAKKKKAELISK GGGTHPLLVPYDTLTAKEKYRDREKAQELFKYLQISGYAITRGLKDMEQESSMEKRFAYK FVKRLLKYIDSAQEFIAHLEATATSGKTDKSPHDQEIKFFAKVLLPLMDQTFKNHCLYFL STPSMNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLLILTHSLDTR TVMKSGSELVKAGFRTFFENGAEDLEKLLEMLKLGKFMQSRAQMKSVTQSINYVTIALLP ILTSLFEHITTHGVDLLLDDVQLSCYRILTCFYSLGTGKNVFVERHLPALGESLATLVGA MPVAFLEPDLNAHNPQSVFNTKTPRERAILSMPDTVEEMCPEMPRLDRLLKDVNDVSESG ARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPEAQCCTMVTSEHLSIILGNILKILNN NLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLDKLRKKTVKVVAEEELLKADSKG DNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSTELFRMVAEIFILW CKSHNFKREEQNFVVQNEINNLGFLTGEGKTKMSKSGGDQERKHKRRRGEYYSIQTSLIV AALKKMLPIGLNMCTPGDQELISVAKIRYSVKDTDDEVKEHLRQNLHLQDKSDDPAVQWQ MNLYKDVVVKSEEPVNSEHTVDRVQSISAAVFHLEQVEQPLRNKKCVWHKLLSKQRKRAV VACFRMAPLYNLPRHRAINFFIPAYQRLWIEAEEYSFEEKLVQDLAKTPMKIVEEEEEEV AEIQPDPLHQLILHFSHNALTERSYLEEDPLYIAYADMMAKSCAEDEEEEEEEGKEKTFE EKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISILNGGNVQVQK KMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSIHTQRGSKVL QNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYW YYSGKDVIDETGKINFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVHGTIGKQMVDTLMESSNNV EMILKFFDMFLKLKDLTTSDNFKEYDPECKGIISKKEFQKSMESQKQYSQSEIEFLLSCA EADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLATFLDLAESVLSYFE PYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEGGESEKMEMFV NFCEDTIFEMQLASQISEPDVVEQPEEEEEEDGHSLLDELAGEEEGTLESASAFTTACRS VKKKITNVRQIFSVKSMRKQFKKIKKLSIREIITGFFSFFWMIFIGFFKGIYGLIFGFFH VIWSSMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVIEGEKVEAIESSGSLETAMTP TGDIAEVDMMLEMLTMPKKEGGKHVEPGLGDVSELSETTSTDHKKKAAVKPVETPESEPE KADTENQEKEDKPKEEKAKEPVVEEKPKTRSSQHKEAAPAFMSSVFALLDVYLNKMLNYL ARNFYNLRFLALFMCFSINFILLFYKVTGEADEEIDDEQQWGSDDEDDVDTLFDMDEFVL QESTGYMLPTLRFLAIFHTVISLLCLLGYYCLKVPLVVFKREKEIARKLEFDGLYITEQP SDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLGLDKSALDFDP TVETVEKEASLLSWLSSIDTKYHIWKLGVVLTDNNFLYLIWYTTMSIFGHFNNFFFAAHL LDIAMCFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPD MKCDDMMTCYLFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLM YLINKDETEHTGQESYVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14535 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgagatccagttcttgagaactgatgacgaggtg gtgctccagtgtgtggccaccatccagaaggagcatcgcaagttctgcctggcggtcgag ggactcggaaaccgtctctgttacttggaatccacatctgaagctaagtatgttcctcca gacctgtgtatttgtaattttgtgttggagcagtccctgtcagtgcgggccctgcaggag atgctggctaacaccgggcagagcagcgaaggggcggctcaggggggtggacaccggacc cttctctatggtcatgccatcctccttcgccactccttcagtggtatgtacttgacctgt ttgaagacatcaaggtctctgacagacaagctgtcatttgatgtcggactacaagaagat tcaataggagaggcctgctggtggaccatccacccggcgtccaagcagagatctgaagga gagaaagtccgcatcggagatgacatgatccttgttagcgtgtcaacggagagatacctg cacctctctatctccaatggcaacagccaggtggacgcctccttcatgcagaccctgtgg aacatccagcctacctgctcctcaggcaacatgctcgtagggtatctgatcggtggtcat gtcatgcgtctttgtcgtgggcacgatgagagcttgaccatccctggagcagacaagagt gaggaggagcagagtatagtgaactttgaggcgggaaagggagcgtcaaaggcccgctca ctttggagactggagcctctccggatcagctggagcggtagccacattcgctgggggcag gcattccgactacggcacctctctaccggccattacctgggcctaaccgaggaccgcgga ctggtcctgcaggacagggagaagtctgacaccgccgccactgccttctgcttcaggccc tccaaggaaaaggtcgactttggcccaaagagggacatcgacggcatgggagtgccagag atcaagtacggagactctgtctgcttcattatgcatgtggcgacaggcctgtggctgtct tacttgtctcccgatgccaaatcatctcgcctgggacccataaaaagaagggcctgcctg cattctgaaggccacacggacgatggactcagcttgcagcgctgtcagcacgaggagtct cgggctgcacgcatcattcgcaacaccacgttcctcttcaccaacttcatcaatgctttg gacagaattgctgagggcgagaccatggatatggcagggtatgttgaagaggtactgcag acgctgaatgacctgatcgagtacttcaaacagcccgattcagagctggagcacgaggag aaacagtgtcttctccgttcactcatcaagcgtcaagatctcttcaaagacgagggcatg ctggccctcctgtccaagtgcatcgaccggatgaacctgtacaacagtgctgttcacttt ggagagatggctggggaggaggcaggcgcagcgtggaaggacattctcaacctcctctat gaactcctggctgcactgattcgtgggaacaggaacaactgcacccaattttcccgcaac ttggactggctggtcagcaaactggagagactggaatcttcatcagggatcctggaagtc ctccactgcatcttgatagaaagtccggaggctctgaacatcattcagagaggtcacatt aaatctataatctctctgctctacaagcatggacgaaaccacaagattctggatgtcctg tgttccctctgtgtttgtaatggagtggcagtgagagccaatcagaatctgatctgtgac aacctgcttcccaagagggatctcctgcttcagactcgactggtcaatgacgttcagagt atgaggccaaacgtcttcctcggcgtggctgagggttcagctcagtataagaagtggtat tttgagctggtgatcgaccaggtggaccacttcgtaaccggggagccgacccacctgagg gtaggctgggccaatactaaaggctatgctccgtaccccggtggaggagagggatggggt ggcaacggtgtcggtgatgacctatactcttatagcttcgatggactttatctttggtca ggccgaatcccgagggcagtggcctccattaaccagcacctgctgaactcagacgatgtg gtcagctgctgtctggatctgggcgctcccagcatgtccttcaggatcaacgggcagcct gtccagggcatgttcgaggacttcaacaccgaagggttcttcttccctgtcgtcagcttt tctgcaggggtcaaggtccgtttcctgttgggtggacgccacggagatttcaagttcctg ccacccgctggttactccccgtgctacgaggcactgttgcctaaagagaagatgcatgta gagcccgtgaaggagtacaagagggaccacgagggagtccgtgacatgctgggaaccacc cagttcctctctcaggcctccttcatccccactcctgttgacaccagccagattgttctt ccccctcacctggacaacgtccgggacaagctggcagaaaacatccatgaactgtggggg atgaacaagattgaactgggctggacctatggcaaggttcgtgacgacaacaagaggcag cacccttgccttgtggatttcaccaagttgcctgaaactgagaggaactacaacgtgcag atgtccagtgaaacactgaagaccctgttggctcttggatgtcatgttggccaggttaat gttcacgctgaggacgatctgaagaaaatcaaacttcccaaagactacatgatgtctaat ggttataagcctgcgccactggagctctctgacgtgaaactgactgcaggtcaggaggct ctagttgataaactggccgagaatgcacacaacgtgtgggccaaagatagaattaaacaa ggatggacctatggcatccagcaggatttgaagagcaggcgtaatcctcgcctggtgcca tatgctttattggacgagcgcaccaagaaatctaacagagacagtctgagagaggccatc aggaccatggttggatatggatatgacatcgaccccccagatcaggaagctccccatgtg gtggatgatcagagcgtcgagaccatccgcctcttccgtgtggagcaaacgtatgcagtg acgacaggaaagtggtactttgagtttgaggccctgagtggaggtgatatgagggttggc tgggccagaccgggctgcaggcctgatgtggaactgggagtggacgaccaggccttcgtc tttgatggatacaggggtcgacgtatgcatgcaggcagccgctacttcggacttccttgg aaaaagggcgacgtggttggttgcatgatcaacatggaggacaaatcaatgattttcacg ctgaacggagaactcctgatcaccagcaagggctctgagctctgctttactgactttgag acagaggacggtttcatccctgtgtgcagtctgggcatgtctcagattggacgtatgaac ctgggcaaggacgccagcacttttaagtactacaccatgtgtggtctccaggaaggcttt gagcccttcgctgtcaacatgaacagagagatcaccatgtggttcagcaagcgtcttcct acctttgtcaacatacccaaggaccacatgtatatcgaggtgacgaggattgacgggaca gtagacagccctccctgcctcaaggtcacccacaagacgtttggcacacagaacagcaac aacgacatggcctactgtagactgagcatgcccgtggaattctactctgcagacaagtta ctggacgaatcactgaaactcagtcatcccacaaaagaagacggaactgttgactatgga agcatcacaacttactaccactcagtgagagtgtttgctggacaggaccctgcgtcagtg tgggtgggctgggtcacacctgactatcattaccatagcaagaacttcagcctcagcaag acgcggagggtcactgtcaccctgggagatgagaggggccgggtccatgaaagtgtccag aggagtaactgctacatggtgtgtggagcagacgcagtcggcccgtcttccaccagccgc tccaactctgacctggagatcggctgtctgatcgacctggccactggcctcgtctctttc actgccaacggcaaggagctgtccacaacatatcaggtggagccaaataccaagcttttc cccgctgtttttgtacgtcctaccagtgcaaatctcttccagtttgaatttgtcaagatc aaggatgcaatgccactatcgtctgccatatttaagagcgagcacaggaacccggtgccg cagtgtccgccacgagtggatgtgcagtccatcgtggccgtgctgtggagccgtatgccg aacacgttcctcagcgtggagactgcaagggtcagcgagaggcacggctgggtggtccag tgcctggagccgctgcagatgctggccgtacatatacctgaggagaacaggtgcttggat atcttggaattatctgagtatgaagacctgagaaagttccactaccacacactgaagctg tactgtgccctctgcgccctgggaaacacccgcgttgctcacgccctctgcagccacctg gaccaatcacagctcctctacaccatcgacaatcagtacctttctggaatgctgagagag ggcttctacaatgccctcatcagcgtccatcttgagacagcaaaagaggctcgcctaatg atgaacaacgagttcatcatccctgtgacagatgagactcgctccatcaagttgttcccc gacgagtccaagcagcactcgctgcccggcgtgggcctgagcacctccctcaaacctcgc gtcaacttctcccccgtcggtatcatcaacacaaagcgccaccagtacctcctcagcccc cagataccgctgggggtcctgaaggagaaggccatcagcatgctcactgaggccgtgcag ggcggaggcacacacatccgagacccggtaggcggcagtgtagagtaccagttcgtcccc atcctgaagctgattggaacgctgttaatcatgggagtcttaactagcgaggaggtgaga ctgattctcctcctgattgaccccaacgtgtttggagaggccaaggagggcgaggaagtc aagggggatgaggtggctgtggctggggagaaggaggaggtgagcaagaatgaggagaag gctgtggaggctggagaggaggagacaaaggagggtaaaccgctggttaaaggcctgctg gagaagtcactgcccgagccggtcaaacagcagatgtgtgagttgctgcactacttctgt gactgcgagctgaggcaccgcatcgaggccatcgtgtccttctccgacagcttcgtgtcc aagctgcagtacaaccagaagttccgctacaacgagctgatgttggcgctcaacatgtcc gccgccgtcactgccaagaagactaaagagtttcgttcccccccgcaggagcagatcaac atcctgttgaatttcagcgcgggggaggactgcccctgtcccgagacgatccaggatgag ctcaactccttccacgaagaactgcgactgcactgtggaattcctgtggaggaggaagag gaagagcaggacacttcgataaagggccgcctcctcgctttactctacaaaatcaaaggt ccacctcagaagacagaggaggaacccacggagaaggaacaggctgcccccaccaacctg aaggagttgatctctcagaccataaccagctgggctcaggagtatcacatccaggaccca gaactggtcagagtgatgttcagcctgctgaggaggcagtatgatggcattggggagctg ctccgggctatgaagaaatcctataccatcagtgccgcgtctgtgcaggatgctattaac ctgctggcatctctgggtcaaatcaggtctctgctgtccgtacgcatgggcaatgaggag gaaaaactcatgattgacggactcagcgacatcatgaacaacaaggttttctaccagcat cccaacctgatgagagtgcttggcatgcacgagactgtcatggaggtcatggtcaacgtg ctgggaggagacaagtcacaggagattgccttccccaagatggtggccagctgttgtcgc ttcttatgctacttctgtcgtattagccgccagaaccagaaagccatgtttgaccacctg agctacctgctggagaacagcagcgtcgggctggcctctgaagctatgcggggctccacg ccactagatgttgcagcatcttcagtgatggacaacaacggcctggctctggccctggag gagcccgatctggagaaggtggtgacatacctggcaggctgtggtcttcagagttgtgcc atgctggttgctaagggttacccagacctcggctggaaccccatagagggagagcgttac ctgtccttcctcaggttcgctgtcttctgcaatggtgagagtgtggaggaaaacgccaac gtggtggtgaagctgctgattagacgtccagagtgtttcggccccgccctgagaggagag ggagggcagggtctgctggccgccatgaaggaggccatcaagatctctgaggatcctgcc ctggacctgcccaagacggccaatggagtcaccgctgggcctggagaggaagaaggagaa gttattcacatgggcaactccatcatgtccttctactcagctcttattgacctgctgggc cgctgcgctccagagatgcatcttatcaatgcgggtaaaggtgaagcgctgcgtatacgg gccatcttgcgctctctggttcccactacagacctggtgggcatcatcagcatccccctc aaaatgcctgtggtcaataaagatggcacagtgacagaaccagacatgtcggcctctttc tgtcctgaccacaaggcccccatggtgctcttcttagacagagtgtacggcatcgaggac cagagcttcctgctccagatgttggaggtcggcttccttcctgacctgcgagcctcggcg tctctagacacggaggtgctgagcaccactgagacggcgttggctatgaacaggtacatt ggctcggccctgctgcctctgctgacccgctgtgccgctctcttcgccggcacagagcac tatgctcagctgattgactccacgctgcacactatctaccggctgtccaaaggccgctca ctcaccaaagcccaaagggacgccatcgaggattgtctgctggctatctgcaagcatctg cgtccctccatgatgcagcagctgctcagacggcttgtgttcgacgttcccatgctcact gaatactgcaaaatacctctccggcttctgaccaaccactatgagcagaactggaagtac tactgcctgccttctggtatgggcagctttggcatagcctccgaagaggagctcctccta acaaagaaactcttctggggaatctttgactccctttctcagaagaagtatgatgctgaa cttttcaaaatggccaacttgtgcctgtgtgccatcgctggagctctgcctccagacttt gtggatgccagtcttggagcaacattggagaaacaggcgtcagtggatgcacagggcaac ttcgatcccaaacccatcaacactgccaatatctctcttcctgaaaaacttgattacatt gccaacaaatatgcagagcattcccatgacaagtggtcctcagagaaggtgtcagcaggc tggaaacatggagacagcttggatgaacaggccaaaacacatccactgctgaagccttat aaagcgctgagtgagaaggagagagaaacataccgctggcccgtaaaggagtcattgaag agcatgctgactatgggctggaacattgagaggaccaaggagggagaagccatgttccaa caacgagagagcgaaaaacaacgaaagacctctgagtctcaggttaatggattcagtcct gctccaatggacttgcgcagtgtcactttgtctagagagatacagggcatggtggaggtg gtagcagaaaattaccacaacatctgggccaagaagaagaaagctgagctcattagcaaa ggaggagggacccacccactgctggttccctatgacaccctgacagctaaagagaagtac agagaccgagagaaggcccaggagctcttcaagtacctgcagatcagtggctatgccatc acaagaggtctgaaggacatggagcaggagtcatccatggagaagcgttttgcctacaag tttgtgaaaaggctgctgaagtacatcgactcagcccaggagtttatcgctcatcttgag gcgacggccaccagtgggaagacagacaaatcccctcatgaccaggaaatcaagtttttt gccaaggttttgcttcctctgatggaccaaacttttaagaaccactgtctctacttcctg tctacgcccagcatgaacctgagcagctgtggctgtgcctccaacaaagagaaggagatg gtcaccagcctgttctgtaagctggcagctcttgtcagacacaggatttctctctttgga agtgactctgcaatgatggtgagctgcctgctcattctcactcactcacttgacaccaga acggtgatgaagtccggctcggagctggtcaaagctgggtttcggactttctttgagaac ggagcggaggacctggagaagctgctggagatgctaaaactggggaagttcatgcagtct cgtgcccagatgaagagcgtcacccagagcatcaactatgtgactatagcactgctgccc atcctcacctccctgtttgagcacatcacaacacatggagtggacctgctgttggatgat gtgcagctgtcctgctaccgaatcttgacctgcttctactctctgggaacaggaaagaat gtttttgtggagaggcatcttccagcgctgggggagagcttggcgacgttggtgggggcc atgcctgtcgcattcctggagcccgacctaaacgcccacaacccgcagtctgtcttcaac actaagacgccccgagagagagccatcctcagtatgcccgacacagtggaggagatgtgt cccgagatgcctcgtctggacagactgctgaaagatgtcaatgacgtctccgagtctggt gctcgctacagtgacatgccacaggtcattgaggtgatccttcccatgctgtgtaactat ctgtcctactggtgggagaaaggcccagagaactcacctcctgaggcccagtgctgcact atggtgacctctgaacacctcagcatcatcctgggaaacatcctcaagatcctcaacaac aacctgggcatcgacgacgccccctggatgaagaggattgcagtctactctcagccaatc atctgcaaggctggggcagatctgctgagaacccacttcctgcccacactggacaaactg aggaagaagactgtgaaggttgtggctgaagaggagctgctgaaggcggacagtaaaggt gacaaccaggaggcggagctgctcatcctggatgagtttgctgtgctctgcagagacctc tacgctttctaccccatgctcatccgctatgtggacaacaacaggtccaggtggctgaag gagccggatgcagactccactgagctcttcaggatggtggctgagatcttcatcctttgg tgcaagtcccataactttaagcgtgaggagcaaaactttgtggttcagaatgaaatcaac aatttgggcttcctgacgggggagggcaagacgaagatgtcaaagtcagggggggaccag gagaggaaacacaagcgccgccgaggcgagtactactccatccagacctctctgattgta gctgccctgaagaagatgcttcccatcggcctcaacatgtgcaccccaggagaccaggag ctcatctccgttgccaagatacgctacagtgtgaaagacaccgatgatgaggtgaaggag cacttgcggcagaatctccatctccaggacaaatctgatgacccggcggtccagtggcag atgaacctgtacaaggatgtggtggtgaagagtgaggaacctgtaaactcagaacacaca gtggaccgagtgcagagcatctctgctgcagtcttccacctggagcaggtggagcagccg ctgagaaataagaagtgtgtgtggcacaagctgctgtccaaacagcggaagcgtgctgtg gtggcttgtttccgcatggctccactctacaatctacccaggcatcgcgctatcaacttc ttcatcccggcctatcagagactttggatagaggcagaggagtactcctttgaggagaag ctagttcaggatctggcaaaaaccccgatgaaaattgtggaggaggaggaagaggaggtg gctgagatccagccagaccctctccaccaacttattctccatttcagccacaatgctctg acagagagaagttacttggaagaagatcctttatatattgcatatgcagacatgatggca aagagctgtgcagaggatgaggaggaagaagaggaggaagggaaagaaaagacttttgag gaaaaggagatggagaagcagaagatcctgtatcagcaggcgaggctgcacgcccgtggg gccgctgagatggtgctgcagatgatcagcgccagcaaaggtcgtctgggccccatggtg acctgcacccttaaattgggaatctccattctaaatggaggcaacgtgcaagttcagaag aaaatgcttgattacctgaaagagaaaagagatgcaggctttttcaagagtctgtcaggg ctgatgcagtcttgcagtgtcctggacttgaatgcatttgagaggcagaataaagcagaa ggacttggcatggtgacagaggaaggttcaatccacactcagcggggttccaaggtgcta cagaatgatgagttcacaaaagatctcttccggtttttgcaactcctgtgtgaggggcac aatggagatttccagaacttcctgagaacccaaactggaaacacaaccacagtcaacatc attatcagcactgtggactatctgcttcgtcttcaggagtctatcagtgacttctactgg tactactctggcaaagatgttattgatgagactgggaaaatcaacttctccaaagcttta tctgttgccaagcagatattcaactcactgactgagtatattcagggcccatgcattggg aaccagcagagtttagctcacagcagactgtgggatgcagttgttggcttcttgcatgta tttgccaacatgcaaatgaagctgtctcaggacgccagtcagattgagctgttgaaggag ctgatggatttacagaaggacatggttgtcatgttgctgtctctgcttgagggtaatgtg gtacatggaacaatcggaaagcagatggttgacaccttgatggagtcttccaacaatgtg gagatgatcctcaagttcttcgatatgttcctcaaactgaaggacctgacgacctccgac aacttcaaagagtatgaccctgagtgtaaaggcattatttcaaagaaggagttccagaag tcaatggagagccagaagcagtacagccagtctgagattgaattcctgctctcctgtgca gaggccgacgagaatgacatgttcaattacaaggagtttgtggagcgattccacgagcca gctaaagacatcggcttcaacgtggcagtgctgctaaccaacctgtctgaacacatgcca cacgactccagactcgcaaccttcttagacctcgcagagagcgtactcagctactttgag ccgtatctgggtcgtattgaaatcatgggcagcgcgaagcggatcgagagggtgtacttt gagatcagcgagtcgagccgcgagcagtgggagaagccgcaggtaaaggagtccaagcgt cagttcatctttgacgtggtcaacgagggcggcgagagcgagaagatggagatgtttgtg aatttctgtgaggacaccatttttgaaatgcagctggcctcacagatctctgagcctgat gtggttgaacagcctgaggaggaggaagaagaagatggacacagtctcctggacgagctg gctggagaggaagagggcaccctggagtctgcctcagcctttaccaccgcatgccgctca gtcaagaagaagatcaccaatgtccgccaaatcttttctgtcaagagtatgcgcaagcag ttcaagaaaataaagaagctgagcatcagggagattattacaggcttcttctccttcttc tggatgatcttcatcggcttcttcaagggaatctacggcctcatatttgggttcttccac gtcatctggtcctccatgtttggcggcggcctggttgagggagccaagaacatgaaggtg acggacatcctcggaaacatgcctgacccaacccagtttggtatacacggagatgtgatt gaaggagagaaggtggaggccatagagtcatcaggaagcttggaaacagccatgacacca acaggcgacatagcagaggtcgacatgatgctggagatgctgacgatgcccaagaaggaa ggaggaaaacatgtggagccgggcttgggtgacgtttcagagttgagtgagaccacctcc actgatcacaagaagaaagctgctgtcaagcccgttgaaaccccagagagtgaaccagag aaagctgacacagagaaccaggagaaggaggacaagccaaaggaggagaaggccaaggag ccagtggtggaggagaagcccaagaccagatcaagtcagcataaagaggcggctcctgcc ttcatgtcgagtgtcttcgctcttctggacgtctatctgaacaagatgctgaactacctg gctcgtaacttctacaacctgcgtttcctggctctcttcatgtgtttttccatcaacttc attcttctcttctacaaggtcactggtgaagcagatgaagaaatagatgatgaacaacag tggggtagtgacgatgaagacgatgtggacacactgttcgacatggatgagtttgtactg caggagagcaccggctacatgttaccaactctgcgcttcctggcaatatttcacactgtc atctcactcctctgtttgctcgggtactactgtctgaaggttcctttggtggtgttcaag agggagaaggagattgctaggaagcttgaatttgacggcctctacatcaccgagcagccg tccgacgatgacatcaagggccagtgggatcgactcgtcatcaacaccccgtctttcccc aacaactactgggacaagtttatcaagcgcaaggtgatcaacaaatacggcgacctgtat ggagctgaacgcatcgctgagctcttaggcctggataagagcgctctggactttgacccc acagtggagactgtcgagaaggaagcttccctgctctcctggctgagctccattgacaca aagtaccacatctggaaactgggcgtggttctgaccgacaataacttcctgtatctgatc tggtacaccaccatgtccatttttggacacttcaacaacttcttcttcgctgcccatctg ctggacatcgctatgtgcttcaagacccttcgtaccatcctgtcctctgtcactcacaac ggcaagcagctcgtgctgactgtgggtctgctggctgtggttgtctatctctacaccgtg gtggctttcaacttcttcaggaagttctacaataagagcgaggacgaagacgagcccgac atgaagtgtgacgacatgatgacatgctatttgttccacatgtacgtgggcgtgagagcc ggaggtggtattggagatgagttggaggacccagctggagacccctatgagctctaccgc atcctgttcgacatcaccttcttcttctttgtcattgtcatcctgctggccatcattcag ggtttgatcattgatgcctttggggagctgagagaccagcaggagcaggtgaaggaggac atggagaccaagtgcttcatctgtggcatcgggaatgactactttgaccggacgcctcac gggtttgaaacccacaccttacaagagcacaacctagccaactacctattcttcctgatg tacctgattaacaaggacgagactgaacacacgggtcaggaatcctatgtgtggaagatg taccaggagagatgctgggacttcttccccactggagactgtttccgtaagcaatacgag gaccagttgggttag

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