KEGG   Panthera leo (lion): 122204704
Entry
122204704         CDS       T10741                                 
Symbol
WNK2
Name
(RefSeq) serine/threonine-protein kinase WNK2 isoform X1
  KO
K08867  WNK lysine deficient protein kinase [EC:2.7.11.1]
Organism
plez  Panthera leo (lion)
Pathway
plez04928  Parathyroid hormone synthesis, secretion and action
Brite
KEGG Orthology (KO) [BR:plez00001]
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    122204704 (WNK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:plez01001]
    122204704 (WNK2)
   01009 Protein phosphatases and associated proteins [BR:plez01009]
    122204704 (WNK2)
Enzymes [BR:plez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122204704 (WNK2)
Protein kinases [BR:plez01001]
 Serine/threonine kinases: Other
  Wnk family
   122204704 (WNK2)
Protein phosphatases and associated proteins [BR:plez01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     122204704 (WNK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr CCTL2_WNK OSR1_C
Other DBs
NCBI-GeneID: 122204704
NCBI-ProteinID: XP_042768233
LinkDB
Position
D4:1192635..1323003
AA seq 2173 aa
MDGDGGRRDGPRALTEAGRGAGPAGMAEPAAVPRARAARPGPQRFLRRSVVESDQEEPPG
LEAAEAPGAQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAAPAAAAAAAAVAPPGSPAD
PGPEPAGAQEPGPDPAPAPPGEPREDEAAAAAAAAGREDAAAPEARPEPGRARRGEPEEE
EDDEDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQ
RFKEEAEMLKGLQHPNIVRFYDFWESSARGKRCIVLVTELMTSGTLKTYLKRFKVMKPKV
LRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSV
IGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPAS
FEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSSIALR
LWVEDPKKLKGKPKDNGAIEFTFDLEKETPDGVAQEMIESGFFHESDVKIVAKSIRDRVA
LIQWRRERIWPALQPPEQRDPGSPDKARGPPAPLQVQVTYHAKAGPPEPEEPEADQHLLP
AALPASATSLASDSTFDSGQGSTVYSDSQSSQQSAVLGSLADAAPPPTQCVCSPPVSASD
GPVLPYSLPSLGPYQQPAVPGLPGSSIPPPARPPLPQQHFPEPAISFAPVSTGPGQPVPA
GQQPPPLAQPAPLPPVLAPPPVGPLQPVPPHLPPYLAPTSQVVAPAQLKPLQMPPAPLQP
LPQVPAQVPPLPVGPPIAPLASMDSLSTALPDLPAATGPAVPSVPAPSQYFSPAVILPSL
PLSAAAAPLPASPALPLQAVKLPHPTGAPLAVPCRTIVPNVAATATAIPLLAVAPQGVAA
LSIHPAAVAQLPAQPVYPAAFPQMVPGDVPPSPLHAAQNVRAAPSQPAPPTLPQPHQPSV
THLPEQAAAAGGAGSQILLGHPPPYAVDVTAQVPTAPVPAAILSPPLPEVLPPPVPELPQ
LPSSLAPVVVAASQNLPVQTTPLLPPTAHPPPPTGLGVASPCPAVQLTVEPVPEEQSSQE
KQPSAPQSCDRACHTGGRNRMQEALVCPGVPAPVSAVQSLLKPCYGPSYGGSDVPSGREM
SDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETH
NHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDVDR
GSDPGVSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAAEAPEP
SPPLPLSSVQPEASQDTAPCKDQLSLKEKSGFPASPQHLSQTGPRDTPGGAPAPLLPSSP
PVTALPQDAATPAASPKPEPSVGTAVQAGGPGTSQGMASERETPQPLAETQDTQLSAQPL
GAGGGPCAPPLEAPRYPSGLGEPTSAREAMAQGEPLQAPAPAPSAPSGTPQPTLGQPLPP
LPPAVGAISLATPQLPSPPLGPTGAPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTL
LYQEHVPTSSASAGTPVEAGDRDLTLEPQPVPGKSETAPGLGAALEQAGSSPLTAESSLS
QVTTSGLPPAPGAPQDAPASAFPALLEPADQSSGVPGETSARPTPGMQTEDSRASHLQTQ
GTLAAGSPQKHPGQQDGSSPAKTVGRFSVVSTQDEWTLGSPHSLRYSAPPDVYLEEAPHS
PDMKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRRRPPVQKHASLPSSSGVASDFVKKAT
AFLHRSPRAGSPGPETPGRVGVKVPTISVTSFHSQSSYISSDNDSEIEDADIRKELQSLR
EKHLKEISELQSQQKQEIEALYRRLGKPLPPNLGLFHTAPPAGRRRKSRSKLKAGKLLNP
LVQQLKVVASSTGHLSDCSRAPPAKDPAQAGAGPEAASDPCGKAVQTQQPCSVRASLSAD
ICSGLATDGGGAHGSGWTVYHPTSERLTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKE
HSSRSSTSSLVPGPEPGPQPTLHVQAQANNSNNKRGTFTDDLHKLVDDWTSKTVGTTQLK
PSLNQLKQTQRLHGMEAPAGWSPATGETRAMNASRAAVGTPCLAPAPSPLSTAAIPGTTP
GLPMPDSESEKPD
NT seq 6522 nt   +upstreamnt  +downstreamnt
atggacggcgatggcggccgccgggacggcccccgcgcgctgacggaggccgggcgcggc
gcggggcccgcgggcatggcggagccggcggcggtgccgagggcgcgggcggcgcggccc
gggccccagcgcttcctgcggcgcagcgtggtggagtcggaccaggaggagccgccgggc
ctggaggcggccgaggcgccgggcgcgcagcccccgcagccgctgcagcgccgggtgctg
ctgctctgcaagacgcgccgcctcatcgccgagcgcgcccgcggccgccccgccgcccct
gcggcccccgccgccgccgccgccgccgccgccgtcgcgccgcccggcagccccgccgac
cccggccccgagcccgcgggcgcgcaggagcccggcccggaccccgcgcccgcgcccccc
ggagaaccccgcgaggacgaggcggcggcggcggcggcggcggcggggcgggaggacgcg
gcggcgccggaggcgaggcccgagccagggcgcgcccgccggggagagcccgaggaggag
gaggacgacgaggacctcaaggccgtggccacctcgctggacggccgcttcctcaagttc
gacatcgaactgggccgcggctcattcaagacggtctacaaggggctggacacggagacc
tgggtggaggtggcctggtgcgagctgcaggaccggaagctcaccaagctggagaggcag
cggttcaaagaggaggccgagatgctcaagggcctgcagcaccccaacatcgtgcgcttc
tatgacttctgggagtccagtgccagggggaagaggtgcatcgtgctggtgaccgagctg
atgacctcggggacgctgaagacgtacctgaagcggttcaaggtgatgaagcccaaggtc
ctgcgcagctggtgccggcagatcctgaaggggctgctgttcctgcacaccaggacgccc
cccatcatccaccgggacctcaagtgtgacaacatcttcatcactgggcccaccggctct
gtgaagatcggcgacttgggcctggccactctcaagagggcgtcctttgccaagagcgtg
atcggcaccccagagttcatggcgcccgagatgtacgaggagcattacgacgagtctgtg
gacgtctatgccttcggcatgtgcatgctggagatggccacctcagagtacccctactcc
gagtgccagaatgcagcccagatctaccggaaggtcacctgtggcatcaagcctgccagc
tttgagaaagtgcatgatcctgaaatcaaggagatcatcggggaatgcatctgcaaaaac
aaggaggaaaggtacgagatcaaggacctgctgagccacgccttcttcgcagaggacacg
ggagtgagggtggagctggcagaggaggaccacggcaggaagtctagcatcgccctgcgg
ctctgggttgaggaccccaagaaactgaagggcaagcccaaggacaacggggctatagag
ttcacctttgacctggagaaggagacgccggatggtgtggcacaggagatgatcgagtcg
ggattcttccacgagagcgacgtgaagattgtggccaagtccatccgcgaccgagtagca
ttgatccagtggcggcgagagaggatctggccggcgctgcagcccccggagcagcgggac
ccaggcagccccgacaaggccaggggcccgcccgcacccctgcaggtccaggtgacctac
cacgccaaggctgggccgccggagcccgaggaacccgaggcagaccagcacctcctgcct
gccgcgctgccggccagcgccacctccctggcctcggatagcacgttcgacagcggccag
ggctccacggtgtactcggactctcagagcagccagcagagtgcggtgctgggctcgctg
gcggacgcggccccgcccccgactcagtgcgtgtgcagtcccccggtgagcgcgagtgac
gggcctgtcctgccgtacagtctgccctcgctggggccctaccagcagcctgccgtgcct
ggactgccggggagctccatcccgcccccagcccgccctccgctcccgcagcagcatttc
ccggagccagccataagttttgctcccgtgtcgacgggcccgggccagcctgtgcctgct
ggccagcagcctcctccactggcccagccggcgcccttgccccctgtcctggccccaccg
cccgtgggccccctccagccggtgccccctcatctgccgccctacctagctccgacttcc
caggtggtggcccccgctcagctgaagcccctccagatgccgccagcacctctgcagcct
ctgcctcaggtgcctgctcaggtgcctccgcttcccgtcgggccgcccattgcgcccctg
gcctccatggacagcctctccacagctctgcccgacctgccggccgccaccgggcccgcc
gtcccctccgtccccgctccctctcagtatttctctcccgccgtcatcttgccaagcctc
ccgctcagcgccgccgccgccccgctgcccgcgtcaccagccctgcccctgcaggcggtc
aagctgccccaccccaccggggcgcctctcgccgtgccgtgccggaccattgtgccaaac
gtggcggccaccgccaccgccatccctctgctggccgtggccccgcagggtgtggccgcc
ctgtccattcacccggccgctgtggctcagctcccggcccagcccgtgtacccggcagcc
tttccgcagatggtgcccggcgacgtcccgccttctcccctccacgcggcgcagaacgtg
cgggctgccccgtcccagcctgcgccccccacgctgccgcagccccaccagccaagcgtc
acacaccttccagagcaggccgctgcggcaggtggggcggggagccagatcttgcttggc
cacccgcctccatacgctgtggatgtcaccgcccaggtccccacggcacccgtgccagcc
gccatcctctccccacctctgcccgaagtgttgccgcctcctgtccccgagctgcctcag
ctccccagctccctggcccccgtagtggtggcggcctctcagaacttgcctgtccagacc
acgccgctcctgccgcccaccgcccacccaccaccacccaccgggctcggggtcgccagc
ccctgcccggccgtgcagctgacggtggagccggtcccggaggagcagtcctctcaggag
aagcagcccagcgccccgcagagctgtgacagagcttgtcacactgggggacggaaccgg
atgcaggaagcactcgtgtgtcctggtgtgccagccccagtcagtgctgtgcaatccctc
ctcaaaccctgctatggccccagctacggaggctccgacgttccctctggaagagagatg
agcgacagctgtgagggtgcatttggtggtgggaggctggagggcagggccgcccggaaa
catcaccgccggtccacgcgtgcgcgctcccgccaggagagagccagccgcccccggctc
accatcctgaacgtgtgcaacacgggcgacaagatggtggagtgccagctggagacgcac
aatcacaagatggtgacgttcaagtttgacctagacggggacgcgcctgacgagatcgcc
acctatatggtggagcacgacttcatcctgcaggccgagcgagagacgttcatcgagcag
atgaaggacgtcatggacaaggcggaggatatgctcagtgaggacacggatgtcgaccgg
ggctccgaccccggggtcagcccgccgcacctcagcacctgcggcctgggcactggggag
gagagtcgccagtcccaagcaaacgcccccgtgtatcagcagaacgttctgcacacgggc
aagaggtggtttatcatctgcccggtggctgagcacccagcggcggaggcccctgagcct
tcaccgccacttcctctgagctccgtgcagccagaagccagccaagacacagcgccctgt
aaagaccagctgtccttaaaggaaaaatccggcttcccagccagtccacagcatctgagc
caaacaggccccagggacacccctggcggtgcaccggcccctttgctgccatcctcccct
cctgtgactgctctgccccaggatgcggccaccccagccgccagccccaagccagagccc
tcagtggggactgctgtgcaggcagggggcccagggacctctcaggggatggccagtgag
cgtgagaccccccagccactggcagagactcaagacacccagctttctgcacaacccctg
ggtgcaggtggggggccttgtgccccacctctggaggccccccgctacccctcgggtttg
ggagagcccacctcagccagggaggccatggcccagggtgagcccttgcaggctccggcc
cctgcacccagcgcccccagtgggacccctcagcccaccctgggtcagcccctacccccg
ttgccccctgcagtaggggccatcagcctggccactccccagctccccagccccccactg
gggcccactggggccccccagccaccctcggccttggagtcagatggggaggggcctccc
cccagggtgggctttgtggacagcaccatcaagagcctagatgagaagcttcgaactctg
ctctaccaggagcacgtgcccacctcctcagcctctgccgggacccctgtggaggcgggg
gaccgagacttgaccctggagccccagcccgtgccgggaaagtcagaaacagcccctggg
ctgggggctgcattggagcaggctgggtcctcgccattgacagcagaatcatctttgagc
caagtgacaacctcaggtttgcccccggcgccaggtgccccccaggatgcccctgcttct
gccttccctgcactcctggagcccgcagaccagagcagtggggtcccgggggaaacttca
gccaggcccacaccggggatgcagacggaagacagccgggccagccacctgcagacgcag
ggcactctggccgcagggtccccacagaagcatccagggcagcaggacggcagctcacca
gccaaaactgtgggccggttctcggtggtcagcacgcaggacgagtggaccctgggctcc
ccccacagcctgcggtactcggcgccgccagacgtgtacctggaggaggccccccacagc
cccgacatgaagctggccgtgcggagggcgcagacagcctcctccatcgaggtcggcgtg
ggcgagccggtgtccagcgactccggggacgagggtccgcgcaggcggccccctgtgcag
aagcacgcctccctacccagcagcagtggcgtggccagcgacttcgtgaagaaggccacc
gccttcctgcacaggtccccacgggctggctccccgggcccggagacgcccggcagagtg
ggcgtgaaggtgcccaccatcagtgtgacctccttccactcccagtcgtcctacatcagc
agcgacaacgactcggagatcgaggacgccgatatcaggaaggagctgcagagtctgcgg
gagaagcacctgaaggagatctcggagctgcagagccagcagaagcaggagatcgaggcc
ctgtaccgccgcctgggcaagccgctgccccccaacctgggcctcttccacacggcccct
cccgccggccgcaggaggaagagcaggagcaagctgaaggcagggaagctgctcaacccg
ctggtgcagcagctcaaggtcgtggcctccagcacaggtcacttgtcagactgcagcaga
gcccctcctgctaaggaccctgcccaagccggggcagggcccgaagcagcttcagacccg
tgtgggaaggcagttcagacccagcagccttgctcggtgcgggcctccctgtctgcagac
atctgctccggcttagccactgacggaggcggagcgcatggctcaggctggacggtttac
cacccaacgtctgagagactgacctataagtctagtagcaaacctcgcgctcgattcctc
agtggacccgtgtctgtgtccatctggtctgccctgaagcgtctctgtctaggcaaagag
cacagcagtcggtcttccaccagcagcctggtcccgggccctgagccgggcccccagccc
accttgcacgtccaggcacaggcgaacaacagcaacaacaagagaggcaccttcacggat
gacctgcacaagctggtggacgactggacgagcaagacggtggggaccacccagctgaag
ccctcgctcaaccagctgaagcagactcagaggctacacggcatggaggccccggcgggc
tggtccccagccactggcgagacacgggctatgaacgcctctcgagcagcagtggggaca
ccatgtctggccccagcgcccagccctctatccaccgcggccattcctggaaccacccca
ggcctgcccatgccagattctgagagtgagaagcccgactga

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