Panthera leo (lion): 122222232 Help Entry 122222232         CDS       T10741                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism plez  Panthera leo (lion) Pathway plez04020   Calcium signaling pathway plez04371   Apelin signaling pathway plez04713   Circadian entrainment plez04921   Oxytocin signaling pathway plez04970   Salivary secretion plez05010   Alzheimer disease plez05012   Parkinson disease plez05020   Prion disease plez05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:plez00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     122222232 (RYR3)    04020 Calcium signaling pathway     122222232 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     122222232 (RYR3)   09154 Digestive system    04970 Salivary secretion     122222232 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     122222232 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     122222232 (RYR3)    05012 Parkinson disease     122222232 (RYR3)    05020 Prion disease     122222232 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     122222232 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:plez04040]     122222232 (RYR3) Ion channels [BR:plez04040]  Voltage-gated cation channels   Ryanodine receptor    122222232 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Phage_TAC_15 Motif Other DBs NCBI-GeneID:  122222232 NCBI-ProteinID:  XP_042798452 LinkDB All DBs Position B3:68481129..69007176 Genome browser AA seq 4863 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCEESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKTRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAGEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKPAKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDGEYEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLENLKKKAVKTVQEEEQLKADTK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHVRNNLHLQEKSD DPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKCPKVEEE EEEETDKHPDPLHQIILHFSRNALTERSKLEDDLLYTSYSSMMAKSCQSGEDEEEEEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTREKVLQ NDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWY YSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVF ANMQMKLSQDSNQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVE MILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAE ADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEP YLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVN FCEDTIFEMQLASQISESDSAERPEEEEEDEDSSYTLEIEGEEEDDKSFESASAFAMACA SVKKNVANFLKKATLKNFRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFQLFFTILGGIF QILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVTEPGITPELVHF VKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRRAQA AEMKASHEAEGKVEPEKTDMEDGEKEGTAKEEEQADALWAEVTKKKKRRRGQKVEKPEAF MANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDIAN LWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAIIHTIISLVCVVGYYCLKVPLVVFKR EKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPSNYWDKFVKRKVINKYGDLYG AERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAW YTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRI VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED QLG NT seq 14592 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgaggactgaagatgaa gtggttctccagtgcatcgcaaacattcacaaggagcagaggaagttctgcctggcagcc gagggcctgggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctgcag gaaatgcttgccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaaaca ctctggaatgtacatcccacgtgctcaggaagtagcatcgaagaaggttacctacttggt gggcatgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgactcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaggaccgggcaaagtcagacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgggatatagaaggc atgggagttccagaaatcaaatacggagattccgtctgctttgtccagcacatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggctaacactgcagagatgc cagtgcgaggagtcccaggctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtggaaacaatcgtacggcggcccccatcaccctgccgatagaagaggtcctg cagaccttacaggacctgatcgcctacttccagcccccggaggaggagatgcaacacgaa gacaaacagaacaagctccgctcacttaagaacagacagaatcttttcaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttaaacatctacaacagcgtggcgcac tttgcaggaattgcaagggaggagagtggcatggcttggaaagagatcctgcgcctgcta tacaaactgctggctgctctcattcgtggaaacagaaacaactgtgctcaattctctaat aacctcgattggctaatcagcaaattggatagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgactgaaagcccagaagccttaaatctgatagcagagggtcac atcaagtctatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgccgtgagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaacgacgtgaca agcattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtgg tactttgagctgatcatagaccaagtggaccccttcctaacagctgagcccacacaccta cgggtgggctgggcctcttcctcaggctatgctccgtaccctggaggtggagaaggatgg ggaggcaacggtgttggagacgacctgtattcctatggctttgatggccttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctgctgagatcagacgac gtggtaagctgttgcctcgacctcggggtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtgcgttttttgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttactgccaaaagaaaagatgaga ttggagcccgtcaaagaatataaacgcgatgctgaaggagttagagatctgttgggtacc acccagttcctctctcaagcctctttcatcccatgccccatagacaccagtcaggtggtt ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgaactttgg ggaatgaataaaatagagcttggctggacttttggcaagacacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaacggaaaccttaaaaacccttctggccctggggtgccacattgctcatgtt aatccagctgctggggaggatctcaagaaagtcaagttgcccaaaaactatatgatgtcc aatggctacaagccagcccctttggatttgtctgatgtgaagctattacctcctcaagaa attttggtggataagcttgcagaaaatgcacataatgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccgtacgcattactggatgagcgtacgaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgagccgtcagaccaagaactagctgac ccagctgtggagaaagtcagcatagataaaattcgatttttccgggtagagcggtcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc gttggctgggccaggccgggctgtcggcccgacgttgagctgggagccgatgatcaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acgtggcagccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatgatc ttcacactgaatggggagctgctgattaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggcttcgtgcccatctgctctctgggactgtctcagatcggccgc atgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaagcgc ctcccgacatttgtcaacgtgccaaaggatcatccgcacatagaggttgtgaggatagat ggcactatggacagccctccatgcctcaaggtgactcacaagacattcggcacacagaat agcaatgccaacatgatctacctacgcctgagcatgcccgtcgaatgccactcctccttc agccacagcccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgcaatccgcatcttcgctggacaggacccc tcctgcgtctgggtcggatgggtcactccggactatcacttgtacagcgaaaagtttgac ctgagtaaaaactgcacagtgactgttactctaggggatgaaagaggccgggtccatgaa agcgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcgcaa agatcaagccggagcaacgtggacctggagatcggctgcctcgtggatctggcgatgggc atgttgtctttctcagccaatgggagagagctcggtacctgctatcaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacttcattgtttcagtttgaa cttgggaagctgaagaatgcgatgcccttgtcggcggccatatttaagagtgaagagaag aacccagttccgcagtgtccacctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggaacgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcactccacatccctgaggagaac aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccac acgctgcgactctacagtgcagtgtgtgccctgggaaacagccgcgtggcctacgcccta tgcggccacgtggatctctcccagctgttctacgccattgacaacaagtacctccctggc ctccttcgttctggtttctatgacctgctcatcagcatccatctggccaatgctaaggag aggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccagaaaaatc cgcctgtatccagatgagtccaagaggcacgggctgcctggggtgggcctgagaacgtgc ctcaagccagggttcaggttctccaccccttgctttgtcgtgaccagtgaggagcaccag aagcagagccctgagatccccttggagattctcaagacgaaggcactgagcatgctgacg gaggcagtgcagcacagcggggctcacatccgggaccctgtcggtgggtctgtagagttc cagtttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgac gatgacgtcaggcagatcctcctcctgatcgatccctctgtgtttggggagcacagtggg gagactgagaacagagcagagaaggaggaagtgacccaggtggaagagaaggcagtggag gccggagaaaaggccggcaaggaggctccagtcaaaggcttactgcagacccgactgcca gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtagaggccattgtggcatttggcgacatttatgtctctaagctccaggcaaat cagaagttccgctacaacgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaaaaccagggagttccgctcacccccccaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccagaagagatccgagaggagctatatgacttccat gaggaccttctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaagac acatcctgggctgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gcgaaggaacagccaacagaggaggaagagagatgccctacgaccttgaaggagctcatc tcacagaccatgatccgctgggctcaggaggaccagatccaggatgcggagttggtccgg atgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagtcaggcctccgtgagcgacaccatcagcctgctggctgcc ctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacattatgaacaacaaggtgttctaccagcatcccaacctcatg cgagtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgttggggacagag aagtctcagattgcctttccaaaaatggttgctagctgttgccgcttcctctgctacttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttacctgttggag aacagcagtgttggcctagcttccccttcgatgaggggatctaccccgctggatgtggca gcttcctccgtgatggacaacaacgagttagccctgggcttagaggaaccagaccttgag aaggtggtgacctatttggcaggctgtggcctgcagagctgccccatgcttctagccaaa gggtaccctgacgtcggctggaaccccatcgaaggggagcgctacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggtcta ttggcagccatgcagggtgccattaagatctctgagaacccagctctcgacctcccctct cagggatataagagagaagtcacggaggacggtgaatatgaagaagagatcgtgcacatg ggcaatgcaattatgtctttctattcagcccttatagatctcctgggccgctgtgctcct gaaatgcatcttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc tccctggtccccactgaggacctggttgggatcatcagcatccccttgaagctgccttcc ctgaacaaagatgggtcggtcagcgagccagatatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggatcgtgtttatggcattaaggatcaaactttcctg ctccacttgctagaggttggatttttacctgacttaagagcctctgcctctctagataca gtttccctaagcaccacagaggccgcactcgcgctaaataggtatctatgttctgctgtg cttccgctcctcacaagatgtgcccctctctttgccggagcagaacactacacctctttg atcgattctacactccagacaatatataggctttccaagggacgttccctcaccaaagcc cagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgaggccttcgatg ttacagcaactcttgcgacgtcttgtctttgatgtgccgcagctcaacgaatactgcaaa atgcctcttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctgcct tcaggatgggggagctacgggctagctgtggaggaggaattgcacctgacggagaagctc ttctgggggattttcgactccctctcccataagaagtatgacccagaccttttccgaatg gcccttccttgtctcagtgctatagctggggcgctaccaccggattacttagataccaga atctcagccacgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaa cccatcaacaccatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaagtac gcggagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggatgaaaatgtgaagacccatccactgataaggcctttcaagacattaaca gaaaaggagaaggaaatttaccgctggcctgctagagagtccctgaaaaccatgttggct gtgggctggtctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaaaat gagaagcttcggagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg gacctctccaacgttgtgctctccagggagctccagggaatggtggaggtcgtggccgag aactatcacaacatctgggccaagaagaagaagctggagctggagagcaaaggtggcggc agtcaccctctgttggtaccatatgacaccttgacagccaaggagaagttcagggaccga gaaaaggcacaggacctgtttaaattcctccaggtgaacggcatcgtggtttctagaggt atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttg aagaagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggttgaccagtacttcaccaatcaccgcctctacttcctgtcatcc cctctaaaacccctcagcagcagtggctatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgtccgacacaggatttccctctttggaagtgat tctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtc atgaagtcaggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcggcg gaagacttagagaagacttcggaaaatctgaagctcgggaagtttacgcattccagaaca cagattaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctg acgtccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgat gtgcagatttcatgctaccacatactctgcagcctctactcccttgggaccggaaagaac atctacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccggtggcattcttggagcccactcttaaccgctacaatccactctcagtcttcaac accaaaacccccagagagaggtctattctggggatgccagacacagtggaagagatgtgt cctgacatccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggg gcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaactac ctgtcctactggtgggagcgggggccagagcacctgccccccagcacggggccctggtgt accaaggtcacctctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaac aacaacctgggcatcgacgaggcatcctggatgaagcgcatcgcagtgtatgcccagcca atcatcagcaaagccaggccggacctgctgaaaagccacttcatcccaactctggagaac ctgaagaaaaaggctgtgaagactgtgcaggaggaggagcagctgaaggccgacaccaaa ggagacactcaggaggcggagctcctcatcctggatgagtttgcagtcctctgcagagac ctctacgccttctaccccatgctcatccgctacgtggacaacaacagatcgaactggctc aaaagtcccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagta aagtctggaggacaggaccaggaacggaagaagaccaagcggaggggagacttgtactcc atccagacctctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaatatg tgcacgccaggcgatcaggagctaatctcccttgcaaagtcacgatacagctatagggat accgatgaagaggtgaaagaacatgtgcggaataacttgcacctgcaggaaaagtcggat gacccagcagtaaagtggcagctgaacctctacaaagatgttttgaagagtgaagaacct tccaatccagaaaagaccgtagagcgtgtacagagaatttccgcagctgtcttccatctg gagcaggtcgaacagcctttgaggtccaagaaggcagtctggcacaaactgttatcaaag cagcggaaacgggcagtggtggcctgtttcaggatggcccctctgtacaacttgcccagg caccgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggag tattcctttgaagagaaactagtacaggacttggctaaatgccccaaggtggaagaggag gaggaggaggagacagacaagcacccagacccacttcatcagatcattctccattttagc cgcaatgctctcacggagaggagcaaattggaagacgacctcttgtacacctcctattcc agcatgatggccaagagttgtcagagtggggaggacgaagaagaagaggaagacaaggaa aagacatttgaagagaaggaaatggaaaagcagaaaaccctctaccaacaagctcgactg catgagcgtggggctgcagagatggtcctccagatgataagtgccagcaaaggtgagatg agccccatggtggttgagactctgaagctggggatcgccattctgaatgggggcaacgct ggtgtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaa agcctttccggccttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag aataaagctgaaggcctggggatggttactgaggaaggaacacgtgaaaaagtactccag aatgacgagttcacacgagatctctttagattcctgcagttactttgtgaaggacataac agtgacttccagaacttcctgcggactcagatgggcaacaccaccactgtcaatgtcatc atcagtaccgtggactacctcctgcgtctgcaggaatcaatcagtgatttctactggtat tattcagggaaggacatcattgatgaatctggacagcacaacttttccaaagctctggca gtcacgaagcagattttcaattctcttacagaatacatccagggcccttgcattgggaac caacagagcctggctcacagcaggctgtgggatgcagtggtcggcttcctgcacgtattt gctaatatgcagatgaaactctctcaggattccaatcagatcgagctgctgaaggaactc ttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggta aatggaactattggcaagcagatggttgacacgctggtagagtcatctaccaatgtagaa atgatcttgaaattctttgacatgttcttgaaacttaaagacctaaccagctcagacacc ttcaaagaatatgacccagatggtaaagggattatctccaaaaaagaattccagaaggcc atggaagggcaaaaacagtacacacagtcagagatcgactttctcctttcatgtgcagaa gctgatgagaatgatatgtttaattacattgattttgtagaccggtttcatgagccggcc aaggacatagggtttaatgtggcagtgttattgacaaatctctccgaacacatgccaaat gattctcgccttaagtgcctattggacccagcagaaagtgtactaaattacttcgaaccc tacctaggacgtattgagatcatgggcggggccaagaaaattgagcgcgtttattttgag atcagtgaatccagtcgaacccagtgggagaagccccaggtgaaggaatctaagcggcag ttcatctttgatgtggtcaatgaaggtggagagcaagaaaagatggaactgtttgtgaac ttctgtgaggataccatctttgaaatgcagttagcgtctcagatctctgaatctgactca gccgaaaggccagaagaggaggaggaagatgaagattcttcttacacgttagaaattgag ggggaagaggaggatgacaagtcttttgagtctgcctctgcatttgccatggcctgtgcc tcagtgaagaaaaacgttgccaacttcctgaagaaggcaaccctgaagaacttcaggaag cagtacaggaaggtgaagaagatgaccgtgaaggagctggtgaaggtgttcttctctttc ttctggatgttatttgtggggctattccagttgttcttcaccatattgggaggaatcttt cagatcctctggagcacagtgtttggagggggcctagtggaaggggcaaagaacatcaga gtgaccaagatcctgggtgacatgcctgacccaacccagtttggtatccatgacgatgcc atggaggctgagcgggcagaggtgactgagccaggtattacaccggaactagtccacttc gtcaagggtgagaaaggagatgcagatatcatgtcagatctctttggattccgctcaaag aaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgatctctctgagattatt ggcaaggatgaaccccctacactagagagtactgtacagaagaaaaggagagcacaggca gcagaaatgaaagcatcacatgaagcagaaggaaaagtggagcctgagaagacagacatg gaagatggggagaaggagggtacggccaaggaggaagagcaagctgacgccctgtgggca gaagtgacaaagaagaagaagcggcgacggggccagaaagttgagaagcctgaagccttc atggctaatttcttcaaagggctggaaatctatcagaccaagttactgcattacctggcc aggaatttctacaacctgaggttcctcgctctgtttgtagccttcgctatcaacttcatc ctgctcttttacaaggtcactgaagagcctttggaagaagagacagaggacattgcaaac ctgtggaattcctttaatgatgaggaagaggaagaagcgatggtgttcttcgtcctacag gagagcactgggtatatggcaccagcactgcgggccttggccattatccacaccatcatc tctttggtctgtgtggtgggctattactgcctgaaggtccctttggtggtgttcaaaaga gaaaaagaaattgccaggaagctggagttcgatggcctgtatatcactgaacagccatct gaagatgacatcaaggggcagtgggaccgcttggtaatcaacacaccatcttttcctagt aactactgggacaagtttgtaaagagaaaggtgattaacaagtatggtgatctctacgga gcagaacgcattgctgaactcctaggtttggacaaaaatgcccttgatttcagcccagta gaagaaagcaaagcagaggcggcctctctggtgtcatggctgagttccatcgacatgaag taccatatctggaagctgggagttgtttttactgataactcctttctctaccttgcctgg tatacaaccatgtcgatcctgggccactacaacaacttcttctttgctgcccatctgcta gacattgcaatgggcttcaagacgctgaggactattctgtcatctgtaactcacaacggc aaacagctggttctgactgtgggtctcctggctgtggtggtttacctctacaccgtggtg gccttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgagcctgatatg aagtgtgacgacatgatgacgtgttacctattccacatgtatgtgggagtaagagcagga ggcggcattggcgacgaaattgaagaccctgctggtgatccttacgaaatgtaccgcatt gtctttgacatcacgttcttcttctttgtcattgtcatcttgctggccatcattcaaggt cttattattgatgcttttggagagctaagagaccagcaggaacaggtgcgagaagatatg gagactaaatgtttcatctgcgggattggcaatgactactttgacacgacccctcatggt tttgaaacacacaccttacaggagcacaacttagccaactatttgttcttcctgatgtat ctgattaacaaagatgaaacagaacacacgggtcaggaatcttatgtctggaagatgtac caagaaaggtgttgggatttcttcccagctggtgactgctttcggaaacaatatgaagat cagcttggataa

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