Panthera leo (lion): 122225168 Help Entry 122225168         CDS       T10741                                  Symbol EP300 Name (RefSeq) histone acetyltransferase p300   KO K04498   E1A/CREB-binding protein [EC:2.3.1.48] Organism plez  Panthera leo (lion) Pathway plez03083   Polycomb repressive complex plez03250   Viral life cycle - HIV-1 plez04024   cAMP signaling pathway plez04066   HIF-1 signaling pathway plez04068   FoxO signaling pathway plez04110   Cell cycle plez04310   Wnt signaling pathway plez04330   Notch signaling pathway plez04350   TGF-beta signaling pathway plez04520   Adherens junction plez04630   JAK-STAT signaling pathway plez04720   Long-term potentiation plez04916   Melanogenesis plez04919   Thyroid hormone signaling pathway plez04922   Glucagon signaling pathway plez04935   Growth hormone synthesis, secretion and action plez05016   Huntington disease plez05152   Tuberculosis plez05161   Hepatitis B plez05164   Influenza A plez05165   Human papillomavirus infection plez05166   Human T-cell leukemia virus 1 infection plez05167   Kaposi sarcoma-associated herpesvirus infection plez05200   Pathways in cancer plez05203   Viral carcinogenesis plez05206   MicroRNAs in cancer plez05211   Renal cell carcinoma plez05215   Prostate cancer Brite KEGG Orthology (KO) [BR:plez00001]  09120 Genetic Information Processing   09126 Chromosome    03083 Polycomb repressive complex     122225168 (EP300)   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     122225168 (EP300)  09130 Environmental Information Processing   09132 Signal transduction    04310 Wnt signaling pathway     122225168 (EP300)    04330 Notch signaling pathway     122225168 (EP300)    04350 TGF-beta signaling pathway     122225168 (EP300)    04630 JAK-STAT signaling pathway     122225168 (EP300)    04066 HIF-1 signaling pathway     122225168 (EP300)    04068 FoxO signaling pathway     122225168 (EP300)    04024 cAMP signaling pathway     122225168 (EP300)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     122225168 (EP300)   09144 Cellular community - eukaryotes    04520 Adherens junction     122225168 (EP300)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     122225168 (EP300)    04935 Growth hormone synthesis, secretion and action     122225168 (EP300)    04919 Thyroid hormone signaling pathway     122225168 (EP300)    04916 Melanogenesis     122225168 (EP300)   09156 Nervous system    04720 Long-term potentiation     122225168 (EP300)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122225168 (EP300)    05206 MicroRNAs in cancer     122225168 (EP300)    05203 Viral carcinogenesis     122225168 (EP300)   09162 Cancer: specific types    05211 Renal cell carcinoma     122225168 (EP300)    05215 Prostate cancer     122225168 (EP300)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122225168 (EP300)    05161 Hepatitis B     122225168 (EP300)    05164 Influenza A     122225168 (EP300)    05167 Kaposi sarcoma-associated herpesvirus infection     122225168 (EP300)    05165 Human papillomavirus infection     122225168 (EP300)   09171 Infectious disease: bacterial    05152 Tuberculosis     122225168 (EP300)   09164 Neurodegenerative disease    05016 Huntington disease     122225168 (EP300)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03000 Transcription factors [BR:plez03000]     122225168 (EP300)    03036 Chromosome and associated proteins [BR:plez03036]     122225168 (EP300)    03029 Mitochondrial biogenesis [BR:plez03029]     122225168 (EP300) Enzymes [BR:plez01000]  2. Transferases   2.3  Acyltransferases    2.3.1  Transferring groups other than aminoacyl groups     2.3.1.48  histone acetyltransferase      122225168 (EP300) Transcription factors [BR:plez03000]  Eukaryotic type   Other transcription factors    Pocket domain CBP     122225168 (EP300) Chromosome and associated proteins [BR:plez03036]  Eukaryotic type   Histone modification proteins    HATs (histone acetyltransferases)     122225168 (EP300) Mitochondrial biogenesis [BR:plez03029]  Mitochondrial quality control factors   Regulator of mitochondrial biogenesis    Coactivators     122225168 (EP300) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  HAT_KAT11 KIX Creb_binding zf-TAZ RING_CBP-p300 PHD_P300 Bromodomain ZZ KIX_2 Npa1 Med15_N Motif Other DBs NCBI-GeneID:  122225168 NCBI-ProteinID:  XP_042803860 UniProt:  A0A8C8X921 LinkDB All DBs Position B4:133647597..133729737 Genome browser AA seq 2425 aa AA seqDB search MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGD ISQLQTSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQGMASQAQQNSPGLGLINS MVKSPMAQAGLTSPNMGMGTSGPNQGPTPSAAGMMNSPVNQPTMGMNTGMNAGMNPGMLN AGNGQGMMPNQVMNGSIGAGRGRPNMPYPNPGMGNAGNLMTEPLQQGSPQMGGQTGLRGP QPLKMGMMNNPNPYGSPYTQNSGQQIGASGLGLQIQTKSVLPNSLPPFAMDKKAVPGGGM PNMGQQQAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANG EVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKN AGDKRNQQSILTGAPVGLGNTSSLGVGQQSTPSLSTVSQIDPSSIERAYAALGLPYQVNQ MPTQPQVQAKSQQTQQSGQSPQGMRPMSNMSASPMGVNGGVGVQTSNLLSDSMLHSAINS QNPMMSENASVASLGPMPTAAQPSNTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAA LKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLP SAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQPGMNQFGQMS MPQPPIGPRQTSPLQHHGQLAQPGTLNPPMGYGPRMQQPSSQSQFLPQTQFSTQGMNVTN MPLAPSGGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPPLPQSALHQNSPSPVPSRT PTPHHTPPSIGAQQPPATAIPAPVPTPPAMPPGPQTQALHPPPRQTPTPPPTQLPPQVQP SLPAAPSADQPQQQPLSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSS TEVNSQTVPEKQPSQEVRMEAKMEVDQPEPADAQPEDIPETKAEDCKMEPTETEERGTEL KTETKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPV DPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVY KYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYH FCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICV LHHEIIWPSGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESG EVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQ EYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACP PSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAK ELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKN KSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLI PCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVET RWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNSQQAAATQSPGDSRRLSIQRCI QSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQEN KCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPT GQQPTTPQTPQPQPPSQPQPTPPNSMPPYLPRTQAPGPVSQGKAAGQVTPPTPPQTAQPP LPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPQMTPMAPMGMNPPPMARGPS GHLEPGMGPTGMQQQPPWAQGGLPQPQQLQPGMPRPAMMSVAQHGQPLNMAPQPGLGQVG VSPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNQ QPLPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMPNMNPMQAGVQRAGLPQQQPPQQQLQP PMGGMSPQAQQMNMNHNAMPSQFRDLLRRQQMMQQQQQQQQGAGPGIGPGMANHNQFQQP QGVGYPPPQQQQQQQQRMQHHMQQMQQGNMGPMGQLPQALGAEAGASLQAYQQRLLQQQM GSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPSSLSNQVRSPQPVPSPRPQSQPPHSSPSP RMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQSSMLSQLASNPGMANLHGAS ATDLGLSTDNSDLNSNLSQSTLDIH NT seq 7278 nt NT seq  +upstreamnt  +downstreamnt atggccgagaatgtggtggaaccggggccgccttcagccaagcggcctaaactctcatct ccggccctctcggcgtcggccagcgatggcacagattttggctctctctttgacttggag catgacttaccagatgaattaatcaactctacagaattgggactaaccaatggtggtgat attagtcagcttcagacaagtcttggcatagttcaagatgcagcctctaaacataaacaa ctgtcagaattgctacggtctggcagttcccctaacctcaatatgggggttggtggccca ggccaaggcatggccagccaggcccaacagaacagtcctggattaggtttgataaatagc atggtcaaaagcccaatggcacaggcaggcttgacttctcccaacatgggaatgggcact agtggaccaaatcagggtcctacgccatctgcagcaggcatgatgaacagtccagtaaat caacctaccatgggaatgaacacagggatgaatgctggcatgaatcctggaatgctgaat gcaggcaatggacaggggatgatgcccaatcaagtcatgaacggttcaattggagcaggc cgagggcgacctaatatgccgtacccaaacccaggcatgggaaatgctggcaatttaatg actgagccactacagcaaggctctcctcagatgggaggacaaacaggattgaggggcccc cagcctcttaagatgggaatgatgaacaaccctaatccttacggttcaccatacactcag aattctggacagcagattggagccagtggccttggtctccagattcagacaaagtctgta ctaccaaatagcttacctccatttgcaatggacaaaaaggcagttcctggtggaggaatg cccaacatgggtcaacagcaggccccacaggtccagcagccaggcctcgtgactccggta gcccaagggatgggttctggagcgcacacggctgatccagagaagcgcaagctcatccag cagcagctcgtgctcctgttgcacgcccacaagtgccagcgccgcgagcaggctaatggg gaagtaaggcagtgcaaccttccccactgtcgcacgatgaagaacgtcctgaaccacatg acacactgccagtcaggcaagtcctgccaagtggcacactgtgcatcttctcgacaaatc atttcacactggaagaattgtacgaggcatgattgtcctgtgtgtctcccccttaaaaat gctggagataagagaaatcaacagtcaattctgactggagcaccagttggacttggaaat actagctctctaggggtgggtcagcagtctacccccagcctaagcactgtcagtcagatt gatcccagctctatagaaagggcctatgcagctcttgggctgccctatcaagtaaatcag atgccgacgcaaccccaggtgcaagcaaagagccagcagactcagcagtctggccagtct ccccaaggcatgcggcccatgagcaacatgagtgctagtcctatgggagtaaatggaggt gtaggggttcaaacatcgaatcttctttctgactcaatgttgcattcagccataaattct caaaacccaatgatgagtgaaaatgccagtgtggcctccctaggtcctatgccaacagca gctcaaccatctaatactggaattcggaaacagtggcatgaagatattactcaggatctt cgaaatcatcttgttcacaaactagttcaagccatatttcctactccggatcctgctgct ttaaaagacagacggatggaaaacttggttgcgtatgcccggaaagtggaaggagacatg tacgaatctgcaaataatcgggccgaatactaccacctgctagctgagaaaatctataag atccagaaagaactagaagaaaaacgaaggactagactacagaaacaaaacatgctacca agtgctgcaggcatggtaccagtttctatgaatccagggcctaatatggggcagccacaa ccaggaatgacttccaatggccctctgcctgacccatctatgatccgtggcagtgtgcca aaccagatgatgcctcggataactccacagcctggtatgaatcaatttggccagatgagt atgccccagcccccaattggaccccggcaaacctctcctcttcagcaccatggacagtta gctcagcctggaactctcaacccaccaatgggctatgggcctcgcatgcagcagccttcc agccagagccagttccttccccagactcagttctcaacacagggaatgaatgtaacgaat atgcctttggctccgtctggcggtcaggcaccggtgtctcaagcacagatgtccagttct tcctgccctgtgaattctcctataatgcctccagggtctcaagggagccacattcactgt ccccctctccctcaatcagctctgcatcagaattcaccctctccagtacctagtcgcacc cccacgcctcaccacactcccccaagcataggggctcagcagccaccagcaacagcaatt ccagcccctgttcctacacctccagccatgccgcctgggccacagacccaagctctccat ccacctccaaggcagacacctacaccgccaccaacgcaactccctccccaagttcaacct tcacttcctgctgccccttccgccgaccagccgcagcagcagcctctctcacagcagagt acagcagcatctgttcccaccccaacggcaccgctgctgcctccgcagcctgcaactcca ctttcccagccagctgtaagcattgaagggcaggtatcgaaccctccatctactagcagc acagaagtgaattctcagaccgttcccgagaagcagccttcacaggaagtgagaatggag gctaagatggaagtggaccaaccagaaccggcagatgcgcagccggaggacatcccagag actaaagcagaagactgtaaaatggaacctacagaaacagaggagagaggcacggagtta aaaactgaaacaaaagaagaggaagaccagccgagtacttcggctacccagtcatctcca gccccgggacagtcaaagaagaagatttttaagccagaagagttacgacaggcactgatg ccaacattggaggcactttaccgacaggatccagaatcccttccctttcgtcaacctgtg gaccctcaacttctaggaatccctgattactttgatattgtgaaaagccccatggatctt tccaccatcaagaggaagttagacactggacagtatcaggagccctggcagtatgtggat gacatttggcttatgttcaacaatgcctggttgtataatcggaaaacatcacgggtgtac aaatactgctccaagctgtctgaggtctttgaacaagaaattgacccagtaatgcaaagc cttggatattgttgtggcagaaagttggagttctctccacagacactctgttgctatggc aaacagttatgcacaatccctcgtgatgccacttactacagttaccagaacaggtatcat ttctgtgagaagtgtttcaatgaaatccaaggggagagcgtttctttgggggatgaccct tcccagcctcaaactacaataaataaagaacaattttccaagagaaaaaatgacacactg gatcctgaactgtttgttgaatgtacagagtgtggaagaaagatgcatcagatctgtgtg cttcatcatgaaatcatttggccatctggatttgtctgcgatggctgcttaaagaaatct gcacgaaccaggaaagagaataaattttctgctaaaaggttgccatctaccaggcttggc acctttctggagaatcgtgtgaatgactttcttaggcgacaaaatcaccctgagtcagga gaggtcactgttcgggtagttcatgcttctgacaaaaccgtggaagtcaaaccaggcatg aaagcaaggtttgtagatagtggagagatggcagaatcctttccataccgaaccaaagcc ctctttgcctttgaagagatagacggtgttgacttatgtttctttggcatgcacgttcaa gagtatggctctgactgccctccgcctaaccagaggagagtttacatatcatacctcgac agtgttcatttcttccgtcctaaatgcttgaggacagcagtgtatcatgaaattctaatt ggatatttagaatacgtcaagaaattaggatatacaacagggcatatttgggcatgtccc ccaagcgagggagatgactatatcttccattgccatcctcctgaccagaagataccgaag cccaagcgactgcaggagtggtataaaaagatgcttgacaaggccgtgtctgagcgaatc gtccatgactacaaggatatttttaaacaagctactgaagatcgattaacaagtgcaaag gagttgccttactttgagggtgatttctggcccaatgttctggaagagagcattaaagaa ctggaacaggaggaggaagagagaaagagagaagaaaacaccagcaacgaaagcacagat gtgacaaagggagacagcaaaaatgctaaaaagaaaaataataagaaaaccagcaaaaac aagagcagcctcagtaggggcaacaagaagaagccaggcatgcccaatgtatccaacgac ctctcgcagaagctgtatgccacaatggaaaaacacaaagaggtcttctttgtgatccgt ctcatcgccggccctgccgccaactccctgcctcccattgttgaccctgaccccctcatc ccctgcgatctgatggatgggcgggatgccttccttaccctcgcaagggacaagcacctg gagttctcttcactgcgcagagcccagtggtccaccatgtgtatgctggtggagctgcac acccagagccaggaccgctttgtctacacgtgcaacgagtgcaagcaccacgtggagacg cgctggcactgcaccgtgtgcgaggattacgatttgtgtatcacctgctataacactaaa aaccatgaccacaaaatggagaaactaggtctcggcctagatgatgagagcaacagccag caggccgcggccacccagagcccaggagactctcgccgcctgagcatccagcgctgcatc cagtccctggtgcacgcctgccagtgccgcaacgccaactgctcgctgccgtcctgccag aagatgaagcgggtcgtgcagcacaccaagggctgcaagcggaaaaccaatggaggctgc cccatctgcaagcagctcatcgccctgtgctgctaccatgccaagcactgccaggagaac aagtgcccggtgcccttctgcctcaacatcaagcaaaagctccggcagcagcagctgcag caccggctgcagcaggcccagatgctccgcaggaggatggccagcatgcagcggaccggc gtggtggggcagcaacaaggcctgccctccccgactcccgccacgcccaccacgcccacc ggccagcagcccaccaccccgcagacgccccaaccccagcccccctctcagccccagcct acccctcccaacagcatgccaccctacttgcctaggactcaggctcctggccctgtctcc cagggtaaggcggcaggccaggtgacccctccgaccccccctcagactgctcagccaccc cttccggggcccccacctgcggcagtggaaatggcaatgcagattcagagggcggctgag acgcagcgccagatggcccacgtgcaaatttttcagaggccaatccagcaccagatgccc cagatgactccgatggcccccatgggtatgaacccaccccccatggccagaggtcccagt gggcatttggagccagggatggggcccacgggcatgcagcaacagccgccgtgggcccaa ggaggcttgcctcaaccccagcaactgcagcccgggatgccaaggccggccatgatgtca gtggcccagcacggtcagcccttgaatatggctccccaaccgggactgggccaggtaggc gtgagccctctcaaaccaggcactgtgtctcaacaagccttacaaaaccttttgcggact ctcaggtctcccagctctcccctacagcagcaacaggtgcttagtatccttcacgccaac ccccagctgttggccgcgttcatcaagcagcgggctgccaagtatgccaactctaaccaa cagcccctccccgggcagcctggcatgccccagggccagccggggctgcagccacctacc atgccgggccagcagggcgtccactctaatccggccatgccgaacatgaaccccatgcag gcaggcgtccagagggccggcctgccgcagcagcagccaccgcagcagcaactccagccg cccatgggagggatgagcccccaggctcagcagatgaacatgaatcacaacgccatgcct tcacagttccgagacctcttgagacggcagcagatgatgcagcagcagcagcagcagcag cagggagccgggcccggaatcggccctggaatggccaaccacaaccagttccagcaaccc cagggagttggctaccccccaccgcagcagcagcagcagcagcagcagcggatgcagcat cacatgcaacagatgcaacaagggaacatgggaccgatgggccagctcccccaggccttg ggagccgaggcaggagccagtctgcaggcgtatcagcagcgactcctccagcaacagatg gggtcccctgctcagcccaaccccatgagcccccaacagcatatgctcccaaaccaggct cagtccccacacctccaaggccagcagatcccttcttctctctccaatcaagtgcgttca ccccagcctgtcccttctccgcggccacagtcccagcccccccactccagcccttccccg aggatgcagcctcagccttctccacaccacgtgtccccacagaccagttctccacatcct ggactggtagctgcccaggccaaccccatggaacaagggcattttgccagcccggaccag agttcaatgctttctcagctcgctagcaatccaggcatggcaaacctccatggtgcaagc gccacggacctgggactcagcaccgataactcagacttgaattcaaacctctcacagagt acactagacatacactag

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